Clinical trials: Spinal Disorders/Injuries, open to volunteers
Spinal Cord Injury, Safety
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
This Phase I clinical trial is designed to evaluate the safety, tolerability of XS228 ( iPSC-Derived Motor Neuron Progenitor Cells) in patients with Subacute Spinal Cord Injury
- Conditions
- Spinal Cord Injury, Safety, Clinical Trials, Efficacy
- Trial name
- NCT06976229
- Testing
- Allogeneic Human Induced Pluripotent Stem Cell (iPSC)-Derived Motor Neuron Progenitor Cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
Spinal Cord Injuries, Neurogenic Bladder
Intravesical LGG VS Saline Bladder Wash RCT
This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).
- Trial name
- NCT05230511
- Testing
- Lactobacillus RhamnosusGG, Saline bladder wash
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Medstar Health Research Institute
Spinal Cord Injury
Neuromuscular Electrical Stimulation and Glucose Control in Spinal Cord Injury
Overall aim: To identify the impact and acceptability of a novel method of neuromuscular electrical stimulation (NMES) for improving glucose control using a dual stable isotope tracer OGTT in individuals with spinal cord injury…
- Trial name
- NMES-SCI (NCT07099911)
- Testing
- NMES
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bath
Spinal Cord Injuries
CNS Changes Following SCI
The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following spinal cord injury and how these changes relate to clinical measures.
- Trial name
- NCT03772548
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injuries
Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury
The purpose of this study is to evaluate if a specific type of additional walking therapy, called body weight supported treadmill training (BWSTT) affects walking ability following a traumatic spinal cord injury.
- Trial name
- PROPEL-SCI (NCT06176833)
- Testing
- Body Weight Supported Treadmill Training
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Milap Sandhu
Spinal Cord Injury, Neurogenic Bowel
Time Comparison of Interventions on Bowel Programs in Spinal Cord Injury
The goal of the study is to find out which of three different options (a suppository, a mini enema, or a transanal irrigation device) takes the least amount of time for completing bowel program amongst those who have spinal cord…
- Trial name
- NCT07817199
- Testing
- Suppository, Enemeez, Peristeen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury
Research on Wireless Brain Implant System for General Control of External Devices
The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive…
- Conditions
- Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- RISE (NCT06829212)
- Testing
- WRS
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Spine Injury, Cord Injury, Spinal
The Outcome of Injured Cervical Spinal Cord With Uncontrolled Swelling Under Duraplasty
Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI).
- Conditions
- Spine Injury, Cord Injury, Spinal, Cord Infarction Spinal, Incomplete Spinal Cord Injury
- Trial name
- NCT06552507
- Testing
- Duroplasty
- Where
- Taiwan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Spinal Cord Injury
Effect of Blood Flow-restricted Exercise Frequency on Strength Recovery Following Incomplete SCI
The goal of this clinical trial is to determine the effect of treatment frequency on the physical recovery of adults with incomplete spinal cord injury.
- Trial name
- NCT07678437
- Testing
- Blood flow-restricted exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Quality Living, Inc.
Spinal Cord Injuries
Upper Extremity Training for Chronic Cervical Spinal Cord Injury
This study is to understand how the combination of activity-based recovery training and targeted spinal cord transcutaneous stimulation (scTS) can improve participants' ability to use their hand, arms, and core.
- Trial name
- NCT04921592
- Testing
- upper extremity stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Kessler Foundation
ALS (Amyotrophic Lateral Sclerosis), TBI Traumatic Brain Injury
Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro
The goal of this study is refine the usability of a BCI capable communication platform. The study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI)…
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), TBI Traumatic Brain Injury, SCI - Spinal Cord Injury, Stroke
- Trial name
- NCT07209943
- Testing
- Cognixion + Apple Vision Pro
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cognixion
Spinal Cord Injuries, Gut Microbiome
Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury
The Investigators will recruit 35 participants with acute SCI (within 6 weeks of injury) Fasting blood collection and bowel function survey will be conducted 3 times: at baseline [within 6 weeks of injury], 6, and 12 months after…
- Trial name
- NCT05670288
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injuries
Early BOTOX After Spinal Cord Injury
The investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI.
- Trial name
- NCT06793683
- Testing
- Bladder chemodenervation (Botox)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Spinal Cord Injuries (SCI)
Health Information for Persons With Spinal Cord Injury
The goal of this pilot study is to design and feasibility test a mobile phone text messaging (SMS) self-management intervention for persons with spinal cord injury (PwSCI).
- Trial name
- NCT07386522
- Testing
- Secondary Health Conditions (SHC) text message group, Motivational text message group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries, Cervical Spinal Cord Injury
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in…
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Respiratory Function Impaired
- Trial name
- NCT05756894
- Testing
- Neurostimulation, Repiratory training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury, Spasticity
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands.
- Conditions
- Spinal Cord Injury, Spasticity, Shockwave Therapy
- Trial name
- NCT07501429
- Testing
- Focused extracorporeal shockwave therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Autonomic Dysreflexia
NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI
This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury.
- Trial name
- NO AD (NCT05635851)
- Testing
- Glyceryl Trinitrate Only Product in Oromucosal Dose Form
- Volunteers
- 26 people
- Sponsor
- Simon Fraser University
Spinal Cord Injury (SCI), Neurogenic Bladder (NB)
Home Neuromodulation for Neurogenic Bladder Management in Spinal Cord Injury
The purpose of this study is to determine the safety and efficacy of Injectrode Tibial Nerve Stimulation for bladder function in people with spinal cord injury.
- Trial name
- NCT07264868
- Testing
- iTNS
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hip Fractures, Arthroplasty, Replacement, Hip
PENG Block + LIA For Endoprosthesis Surgery
The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery.
- Conditions
- Hip Fractures, Arthroplasty, Replacement, Hip, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- PENG 360° (NCT07239817)
- Testing
- Pericapsular Nerve Group Blocks with Local Infiltration Analgesia, spinal anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Gaetano Pini-CTO
Spinal Cord Injuries
Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury
The goal of this interventional study is to understand how regular yogic breathing practice, particularly a slow resistive yogic breathing technique called Ujjayi, would benefit individuals between the ages of 18 and 60 with…
- Trial name
- NCT06514950
- Testing
- Ujjayi Yogic Breathing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital