Clinical trials: Spinal Infection
Spinal Infection, Diagnositic Efficacy
Diagnostic Efficacy of Metagenomic Next-generation Sequencing in Patients With Spinal Infections: A Retrospective Study
Comparing the diagnostic efficacy between traditional laboratory methods and second-generation high-throughput sequencing in patients suspected of spinal infections.
- Trial name
- NCT06172153
- Testing
- No interventions
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Spinal Cord Injuries, Urinary Tract Infections
Immunomodulation Therapy for Urinary Tract Infections
Urinary tract infections (UTI) represent one of the most common morbidities in individuals with spinal cord injury (SCI) and reason for re-hospitalization.
- Trial name
- UROVAXOM-P (NCT04049994)
- Testing
- Uro-Vaxom
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Infection, Spinal Injuries
The Value of Home Chlorhexidine Pre-Surgical Wash Before Spine Surgery
The study team hypothesizes that at-home cleansing of the surgical site with chlorhexidine wipes provide no added benefit to decreasing microbial activity or preventing surgical site infections.
- Trial name
- NCT02767427
- Testing
- Chlorhexidine Wipes, No intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
Spinal Stenosis Lumbar, Surgical Site Infection
Efficacy of ActiveMatrix on Spinal SSI Rate
This clinical trial seeks to provide high level of evidence on the efficacy of ActiveMatrix primarily on spinal surgical site infection rate.
- Conditions
- Spinal Stenosis Lumbar, Surgical Site Infection, Back Pain Lower Back Chronic
- Trial name
- NCT05297513
- Testing
- ActiveMatrix
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Infection, Intervertebral Disc Herniation
Subclinical Propionibacterium Acnes Infection Estimation in the Intervertebral Disc (SPInE-ID)
Subclinical infection of the intervertebral disc after lumbar disc herniation surgery has been correlated to chronic low back pain and vertebral endplate changes. The most commonly reported agent is Propionibacterium acnes.
- Conditions
- Infection, Intervertebral Disc Herniation, Propionibacterium Infection, Spinal Diseases
- Trial name
- SPInE-ID (NCT03158766)
- Testing
- Microdiscectomy
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- Hospital Israelita Albert Einstein
Spinal Fusion Acquired
Intrawound Vancomycin Powder in Spinal Fusion Surgery
Vancomycin powder (for solution for Infusion) will be investigated (off-label usage) in spinal fusion surgery. The powder will be locally administered into to the wound cavity before wound closure.
- Trial name
- iVRCT (NCT02631408)
- Testing
- Vancomycin
- Where
- Austria
- Volunteers
- 308 people
- Sponsor
- Orthopedic Hospital Vienna Speising
Intermittent Urethral Catheterization, Spinal Dysraphism
The Effect of Nursing Interventions for Clean Intermittent Catheterization Caregivers and Child
In neurogenic or non-neurogenic bladder disorders, the removal process after the catheter is inserted into the bladder and the urine has been drained is called Clean intermittent catheterization (CIC).
- Conditions
- Intermittent Urethral Catheterization, Spinal Dysraphism, Urinary Tract Infections
- Trial name
- NCT04763382
- Testing
- experimental group: Training of caregivers, Control gruop
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Spinal Cord Injury
Gastrointestinal and Urinary Tract Microbiome After SCI
Changes in the GI microbiota and/or metabolomics have been linked to evolving transformations in immune system function and infection rates in experimental SCI in animal models.
- Trial name
- NCT02903472
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 43 people
- Sponsor
- University of British Columbia
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection
Infection after spinal surgery is one of the serious complications. Spinal surgery infection can cause high morbidity, mortality, and costs.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Scoliosis Lumbar Region, Lumbar Spondylolisthesis
- Trial name
- NCT04341831
- Testing
- Teicoplanin
- Volunteers
- 120 people
- Sponsor
- Bezmialem Vakif University
UTI, Neurogenic Bladder
Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods)
Due to the damage caused to the spinal cord, patients with spinal cord injury, cauda equina syndrome, multiple sclerosis and transverse myelitis may encounter loss of bladder function, which in turn can lead to a debilitating and…
- Conditions
- UTI, Neurogenic Bladder, Antibiotic Resistance
- Trial name
- PReSuTINeB (NCT02591901)
- Testing
- Uro vaxom
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Catheter Infections, Spinal Catheter (Epidural) (Subdural); Complications, Infection or Inflammation
Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch
Joint replacement is becoming an increasingly common procedure. In 2005, 534,000 total knee arthroplasties (TKA) were performed in the United States which is at a rate of 18.1 per 10,000 individuals, and the demand for primary…
- Trial name
- NCT01411891
- Testing
- Chlorhexidine impregnated patch (Biopatch)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Cesarean Section; Complications, Wound, Infection (Following Delivery), Postoperative Pain
Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section
Many drugs with various mechanisms of action are used for postcaesarean pain relief. Although the response to pain relief is sometimes believed to be individual, it is very important to establish the most effective with the least…
- Conditions
- Cesarean Section; Complications, Wound, Infection (Following Delivery), Postoperative Pain, Spinal Anaesthesia During the Puerperium
- Trial name
- NCT03626753
- Testing
- Nefopam 20 MG/ML, "Nefopam (Acupan)" 20 MG/ML Injectable Solution, "Acetaminophen, (paracetamol)" 500Mg Tab
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Centre de Maternité de Monastir
Metastatic Disease, Spinal Cord Injury
Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
The purpose of this study is to determine if the use of the Prevena™ System decreases the rate of subcutaneous seroma, superficial wound dehiscence and infection.
- Conditions
- Metastatic Disease, Spinal Cord Injury, Spinal Degeneration, Spinal Deformity
- Trial name
- NCT03632005
- Testing
- Vacuum Assisted Closure, Sterile dressing
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- John Street
Spinal Diseases, Spinal Fusion
Intraoperative Disinfection by Pulse Irrigation With Povidone-Iodine Solution in Spine Surgery
The purpose of this study was to evaluate the efficacy, in preventing Spinal Surgical Infection, of intraoperative pulsatile irrigation with a 2000-ml saline solution of PVP-Iodine in a group of patients undergoing complex spine…
- Conditions
- Spinal Diseases, Spinal Fusion, Spine Injury, Infection, Hospital
- Trial name
- NCT03249363
- Testing
- Group A - Pulsed PVP-I Irrigation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rome Tor Vergata
Instrumented Spinal Fusion
Transdermal Continuous Oxygen Therapy for Infection Prophylaxis in High- Risk Patients Undergoing Instrumented Fusion
EPIFLO® unit along with standard wound care vs only standard wound care for Surgical site infections (SSI).
- Trial name
- NCT02615379
- Testing
- EPIFLO
- Where
- United States
- Sponsor
- Neogenix, LLC dba Ogenix
Urinary Tract Infection
Efficacy of Micro-Patterned Foley Catheter to Reduce Catheter-Associated Urinary Tract Infection
The purpose of this study is to determine if the study Foley catheter with its patterned external surface can delay the time to the onset of urinary tract infection in spinal cord injury patients who are dependent on a Foley…
- Trial name
- NCT02198833
- Testing
- Urine Culture, Foley Catheter Tip Culture, Scanning Electron Microscopy
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Baylor College of Medicine
Neurogenic Bladder
Incidence of Urinary Tract Infection After Urodynamic Investigation
The purpose of this study is to evaluate the incidence of urinary tract infection after urodynamic investigation and to identify the involved germs.
- Trial name
- NCT01297647
- Testing
- urodynamic examination
- Where
- Switzerland
- Volunteers
- 317 people
- Sponsor
- Balgrist University Hospital
Urinary Tract Infection
Role of Residual Urine and Asymptomatic Prostatitis in the Development of Urinary Tract Infections in Spinal Cord Injury
The purpose of this prospective study is to investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (>2 /year) symptomatic urinary tract…
- Trial name
- NCT01601041
- Testing
- sonographic assessment of residual urine, urine culture
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Urinary Tract Infection
Efficacy Study of Antimicrobial Catheters to Avoid Urinary Infections in Spinal Cord Injured Patients
The purpose of this trial is to make a comparison between the use of antiseptic silver alloy-coated silicone urinary catheters and the use of conventional silicone urinary catheters in spinal cord injured patients to prevent…
- Trial name
- ESCALE (NCT01803919)
- Testing
- Silver Alloy-Coated Urinary Catheters, Conventional Urinary Catheter
- Where
- 20 sites in Chile, Italy and 3 more
- Volunteers
- 489 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Surgical Wound Infection, Spinal Deformity
Comparison of Antibiotic Protocols in Spine Patients With Postoperative Drains
In spine surgery, postoperative spinal drains are often utilized to prevent fluid buildup around the spinal cord. The purpose of this study is to determine whether postoperative antibiotic treatment continued for the duration of…
- Conditions
- Surgical Wound Infection, Spinal Deformity, Spinal Degeneration
- Trial name
- NCT01608854
- Testing
- Antibiotic Protocol
- Where
- United States
- Volunteers
- 539 people
- Sponsor
- NYU Langone Health