Clinical trials: Spinal Injections
Lumbar Radiculopathy, Lumbar Disc Herniation
Treatment Response to TFESI and DRG Pulsed RF in Lumbar Spinal Stenosis and Disc Herniation
Lumbar radiculopathy caused by conditions such as lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS) can lead to chronic pain and reduced quality of life.
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Lumbar Spinal Stenosis (LSS)
- Trial name
- NCT07509580
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Marmara University
Degenerative Disc Disease
Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
The primary purpose of this study is to evaluate the efficacy of rexlemestrocel-L+HA compared to control in reducing low back pain at 12 months post-treatment and safety of a single injection of rexlemestrocel-L+HA injected into…
- Trial name
- HyaluronicAcid (NCT06325566)
- Testing
- Rexlemestrocel-L + HA mixture, Saline
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- Mesoblast, Ltd.
Transverse Myelitis
Study to Investigate the Safety of the Transplantation of Human Glial Restricted Progenitor Cells Into Subjects With Transverse Myelitis
This study is a non-randomized, open-label, partially blinded, sequential cohort, dose-escalation study designed to obtain preliminary data on the safety, tolerability, and early activity of Q-Cells® transplantation in subjects…
- Trial name
- NCT03887273
- Testing
- Q-Cells
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Q Therapeutics, Inc.
Muscle Spasticity, Spinal Cord Injury
Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study
Spasticity is a common complication following central nervous system injuries. Left untreated, spasticity can lead to various complications, hindering activities of daily living and diminishing independence.
- Conditions
- Muscle Spasticity, Spinal Cord Injury, Stroke, Traumatic Brain Injuries
- Trial name
- NCT06733025
- Testing
- Tendon lengthening surgery, BoNT Injections
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region
Moderate to Severe Plaque-type Psoriasis
Efficacy and Safety of Subcutaneous Secukinumab for Moderate to Severe Chronic Plaque-type Psoriasis for up to 1 Year
This study will assess the safety and efficacy of secukinumab compared to placebo in patients that have moderate to severe, chronic, plaque-type psoriasis.
- Trial name
- ERASURE (NCT01365455)
- Testing
- secukinumab 150 mg
- Where
- 88 sites in United States, Argentina and 10 more
- Volunteers
- 738 people
- Sponsor
- Novartis Pharmaceuticals
Spondyloarthritis
Effect of Two Methotrexate in Sync With the First Adalimumab to Prevent the Immunisation Anti Ada in Spondyloarthritis
Preliminary report have demonstrated that methotrexate induces an anti bio-medicament tolerization whan administrated just before the first administration of the bio-medicament.
- Trial name
- MESYNAD (NCT04360785)
- Testing
- Methotrexate
- Where
- 17 sites in France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis (ALS)
An IIT Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of a Single Intrathecal Injection of SNUG01 in Patients with Amyotrophic Lateral Sclerosis
This is a multicenter, open-label, single-arm investigator-initiated clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of SNUG01 in patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- ALS (NCT06645197)
- Testing
- SNUG01
- Where
- 5 sites in China
- Volunteers
- 7 people
- Sponsor
- Peking University Third Hospital
Intervertebral Disc Herniation, Back Pain
Immune Response During the Conservative and Minimal Invasive Treatment of Pain Caused by Lumbar Disc Herniation
Bulging of the intervertebral disc in the lumbar part of the spine is one of the most common degenerative changes of the spine in the elderly population, which causes various symptoms such as radicular pain.
- Conditions
- Intervertebral Disc Herniation, Back Pain, Analgesic Nephropathy, Inflammatory Response
- Trial name
- NCT06545812
- Testing
- Transforaminal epidural steroid injection, Physical therapy for disc herniation
- Where
- Croatia
- Volunteers
- 128 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Low Back Pain, Disc Disease
Fibrin for Chronic Multi-level Discogenic Low Back Pain
Intra-annular injections of non-autologous fibrin for moderate to severe chronic low back pain (LBP).
- Conditions
- Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy
- Trial name
- NCT04621799
- Testing
- Fibrin sealant
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Pauza, Kevin, MD
Cervical Radiculopathy, Cervical Spondylosis
Transcutaneous Auricular Vagus Nerve Stimulation Combined With Cervical Epidural Injection for Cervical Radiculopathy
This is a prospective, randomized, double-blinded, sham-controlled trial conducted to investigate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) combined with cervical epidural injection in…
- Conditions
- Cervical Radiculopathy, Cervical Spondylosis, Radicular Pain
- Trial name
- NCT07557823
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Cervical Epidural Injection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Spondylolisthesis, Lumbosacral Region
Korean Medicine for Symptomatic Lumbar Spinal Spondylolisthesis
This is a clinical trial for evaluating the safety and effectiveness of the Mokhuri intensive treatment program regarding pain and function before and after treatment between a group receiving the Mokhuri intensive treatment…
- Trial name
- NCT03107468
- Testing
- Mokhuri intensive treatment, Non-surgical conventional standard treatment
- Where
- 2 sites in United States, South Korea
- Volunteers
- 115 people
- Sponsor
- Kim Ki Ok
Pain, Postoperative
Effects of Intra-Operative Ropivaciane Epidural Injection on Post-Operative Outcomes Following Elective Lumbar Fusion
The following is a double blinded, randomized controlled clinical trial to test the hypothesis that a single epidural injection of Ropivaciane® intra operatively will:1) Single intra-operative epidural injection of Ropivaciane®…
- Trial name
- NCT03035656
- Testing
- Ropivacaine, Saline
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Horizon Health Network
Low Back Pain, Mechanical
Short Terms Effects of Medial Branch Block vs Para-spinal Muscle Injection in Patients With Non-specific CLBP
This study compares the efficacy of medial branch block (MBB) vs. paravertebral deep intramuscular (PDI) injection for pain relief in chronic low back pain.
- Trial name
- NCT02521519
- Testing
- Medial branch block in one side, paravertebral deep intramuscular (PDI) injection
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sciatica
Comparing the Efficacy of Steroid, Acupuncture and Platelet Rich Plasma Injection in Patients With Sciatica
Disc herniation, stenosis of the spine and spondylolisthesis are the common causes of radiculitis in medical practice today, and can cause symptoms of sciatica.
- Trial name
- NCT03801512
- Testing
- Steroid, Acupuncture, Platelet Rich Plasma
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei Medical University Hospital
Anklyosing Spondylitis
16 Week Efficacy and 5 Year Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Ankylosing Spondylitis
This study assessed the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who were tolerant to or had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor
- Trial name
- MEASURE2 (NCT01649375)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 53 sites in United States, Austria and 11 more
- Volunteers
- 219 people
- Sponsor
- Novartis Pharmaceuticals
Low Back Pain
Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain
To demonstrate clinically significant improvements or lack thereof in the caudal epidural patients with our without steroids. To evaluate differences in outcomes in patients receiving steroids compared to those patients…
- Trial name
- NCT00370799
- Testing
- Caudal epidural injection, Caudal Epidural Injection with generic Celestone, Caudal Epidural Injection with Celestone
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Pain Management Center of Paducah
Post Operative Pain
Continuous Versus Single-Shot Spinal Anesthesia for Orthopedic Surgery
A study was conducted to compare the effectiveness of continuous spinal anesthesia (CSA), single-shot spinal anesthesia (SSSA), and general anesthesia (GA) in patients over 60 years of age undergoing elective surgical repair of a…
- Trial name
- NCT06625606
- Testing
- Bupivacaine 0.5% Injectable Solution, Isoflurane Inhalant Product
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Benha University
Lumbar Radiculopathy Due to Spinal Nerve Compression
The Effects of Use of Mirror Image on Radiation Exposure During Fluoroscopically Guided Transforaminal Epidural Injection
Lumbar Transforaminal Epidural Injection is helpful for the treatment of lumbosacral radicular pain. Tunnel view technique is the basis of X-ray assisted intervention.
- Trial name
- NCT03341182
- Testing
- Fluoroscopically Guided Lumbar Transforaminal Epidural Injections, conventional manner
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Lumbar Disc Herniation With Radiculopathy
Comparison of the Effectiveness of Ultrasound-Guided Periradicular Injections in Patients With Lumbar Radicular Pain
This study aims to compare the effects of different ultrasound-guided periradicular injection solutions in patients with chronic unilateral radicular pain caused by a single-level lumbar disc herniation.
- Trial name
- NCT07771374
- Testing
- Lidocaine Hydrochloride 2% Injection Solution, Dexamethasone 4 Mg/mL Injectable Solution, Dextrose 5% Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Complications; Cesarean Section, Hypotension
Extra Sitting Time After Spinal Anesthesia for Cesarean Section and Fetal Well-being
After injection of the spinal anesthetic drug, women will be allowed to lie down immediately (0-30 sec) or after three minutes (180 sec) of sitting.
- Trial name
- NCT02893696
- Testing
- Various sitting time
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center