Clinical trials: Spinal Paralysis
Cerebral Palsy, Acquired Brain Injury
Safety and Usability of a Robotic Gait Device for Children and Adolescents With Neurological or Neuromuscular Disease in Their Natural Environment
The goal of this clinical trial is to analyze the usability and safety of the robotic gait device EXPLORER in children with cerebral palsy, acquired brain injury and spinal muscular atrophy.
- Conditions
- Cerebral Palsy, Acquired Brain Injury, Spinal Muscular Atrophy
- Trial name
- NCT06167954
- Testing
- EXPLORER
- Where
- 5 sites in Spain
- Volunteers
- 50 people
- Sponsor
- MarsiBionics
Spinal Cord Injury, Osteoporosis
Early Intervention to Reduce Bone Loss After Spinal Cord Injury
After a complete spinal cord injury (SCI), the patient becomes wheelchair-dependent, and the associated lack of weight-bearing and inactivity of paralysed muscles can lead to extensive bone loss in the long bones of the legs.
- Trial name
- NCT02334410
- Testing
- Whole body vibration (WBV)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Strathclyde
Spastic Tetraplegia, Pain
ESWT for UE Pain in Patients With Cervical Spinal Cord Injury
This study aimed to investigate the efficacy and safety of extracorporeal shockwave therapy (ESWT) for upper extremity pain related to spasticity in patients with spinal cord injury.
- Conditions
- Spastic Tetraplegia, Pain, Myelopathy Cervical
- Trial name
- NCT04319679
- Testing
- Extracorporeal shockwave therapy
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Bundang CHA Hospital
Spina Bifida, Cerebral Palsy
Grand Valley State University (GVSU) Skills on Wheels
Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them.
- Conditions
- Spina Bifida, Cerebral Palsy, Genetic Disease, Spinal Cord Injuries
- Trial name
- NCT05339932
- Testing
- Manual Wheelchair Skills Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Spinal Cord Injury, Amyotrophic Lateral Sclerosis
iBCI Optimization for Veterans With Paralysis
VA research has been advancing a high-performance brain-computer interface (BCI) to improve independence for Veterans and others living with tetraplegia or the inability to speak resulting from amyotrophic lateral sclerosis…
- Conditions
- Spinal Cord Injury, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked-in Syndrome
- Trial name
- NCT05470478
- Testing
- Mobile neural decoding platform (mobile iBCI)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Acute, Paraplegia
Functional Electrical Stimulation Cycling in SCI
Spinal cord injury (SCI) is a devastating, life-altering injury; requiring tremendous changes in an individual's lifestyle. Cycling, provides an ideal way for individuals with SCI to exercise and address the long-term…
- Conditions
- Spinal Cord Injury, Acute, Paraplegia, Tetraplegia
- Trial name
- NCT04064385
- Testing
- FES Cycling
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Glasgow Caledonian University
Spinal Cord Injuries
Transformation of Paralysis to Stepping
The main goal of the project is to develop multiple noninvasive neuromodulatory strategies to facilitate full weight bearing stepping overground in people with paralysis.
- Trial name
- NCT04105114
- Testing
- Buspirone, Non-invasive Spinal Cord Stimulation, Overground stepping
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Traumatic Brain Injury, Traumatic Brain Injury (TBI)
Spinal Stimulation and Gait Training to Improve Mobility in TBI
The purpose of this research study is to assess the effects of receiving transcutaneous spinal stimulation while performing walking exercises compared to completing walking exercises without spinal stimulation for individuals…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI), Hemiplegia and Hemiparesis
- Trial name
- DOD SS (NCT06886152)
- Testing
- Transcutaneous Spinal Cord Stimulation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Healthy, Amyotrophic Lateral Sclerosis
P300 Brain Computer Interface Keyboard to Operate Assistive Technology
The purpose of this research is to develop tools enable people who are paralyzed to operate technology and access computers. These tools are called brain computer interfaces (BCIs).
- Conditions
- Healthy, Amyotrophic Lateral Sclerosis, Neuromuscular Disease, Spinal Cord Injury
- Trial name
- NCT00860951
- Testing
- Brain Computer Interface Keyboard
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anarthria, Dysarthria
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with…
- Conditions
- Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Speech-01 (NCT05724173)
- Testing
- BrainGate Neural Interface System
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Cerebral Palsy, Scoliosis
Prospective Study of Cerebral Palsy Scoliosis
This is a prospective, multi-centre study that will be looking at two groups of males and females over the course of their operative treatment for cerebral palsy (CP) scoliosis and the years following that treatment.
- Trial name
- NCT00958542
- Testing
- Surgical fusion
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries, Paralysis
Autologous Adipose Derived Mesenchymal Stem Cells for Spinal Cord Injury Patients
The purpose of this research study is to investigate the safety and potential therapeutic effects of autologous, culture-expanded, adipose derived mesenchymal stem cell intrathecal injections in the treatment of spinal cord…
- Trial name
- NCT04520373
- Testing
- Best Medical Management: Occupational and Physical Therapy, Autologous, Adipose Derived Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Spinal Cord Injury (Quadraplegia)
Reanimation in Tetraplegia
The purpose of this clinical study is to allow the investigation of the Neural Bridging System for participants with tetraplegia to assess if the investigational device can reanimate a paralyzed limb under voluntary control by…
- Trial name
- NCT01997125
- Testing
- Neural Bridge System
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Marcia Bockbrader
Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level
Neuromodulation With Spinal Stimulation Methods
This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT06272279
- Testing
- spinal stimulation-DCS, spinal stimulation-EPS
- Where
- 2 sites in Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cervical Spinal Cord Injury, Tetraplegia
Testing the Decision Aid: Supporting Patient Decisions About Upper Extremity Surgery in Cervical SCI
Purpose: The objective of this study is to assess a newly created decision support intervention (DSI) or decision aid (DA) for people with spinal cord injury (SCI) to learn about and consider upper extremity reconstructive…
- Trial name
- NCT04995796
- Testing
- Surveys for Research Purposes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries
Experience of Rehabilitation Amongst Individuals With Paraplegia
This study is a qualitative study exploring the facilitators to physical and vocational rehabilitation and also explores the barriers in empowering individuals with paraplegia
- Trial name
- NCT05267223
- Testing
- Semi-structured interviews
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Asir John Samuel
Tetraplegia/Tetraparesis
Comparison of the Effects of Robotic Rehabilitation, Functional Electrical Stimulation and Occupational Therapy on Upper Extremity and Hand Functions in Tetraplegic Patients With Spinal Cord Injury
2. Purpose and Significance of the Study (Primary and Secondary Objectives, if any) Spinal cord injury (SCI) is a clinical condition characterized by partial or total loss of motor, sensory, and autonomic functions below the…
- Trial name
- NCT06912217
- Testing
- robotic rehabilitation, Functional Electrical Stimulation, occupational therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara City Hospital Bilkent
Cervical Spinal Cord Injury
Efficacy of a Brain-Computer Interface Controlled Functional Electrical Stimulation Therapy for Spinal Cord Injury Neurorehabilitation
The study's main goal is to determine the efficacy of a therapy with brain-computer interface controlled functional electrical stimulation for neurorehabilitation of spinal cord injury patients' upper limbs.
- Trial name
- NCT05343130
- Testing
- Brain-Computer Interface
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Spasticity as Sequela of Stroke, Spastic Cerebral Palsy
Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy
A scientific study is being done to test a special treatment for people who have spasticity or tight muscles. This treatment is called "stereotactic radiosurgery dorsal rhizotomy." It uses very accurate beams of radiation to…
- Conditions
- Spasticity as Sequela of Stroke, Spastic Cerebral Palsy, Spasticity, Muscle
- Trial name
- SPASM (NCT06070233)
- Testing
- stereotactic radiosurgery (SRS) dorsal root rhizotomy radiomodulation
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Ohio State University
Spinal Cord Injury
Spinal Cord Injury Epidural Stimulation
This is a feasibility study to test the use of epidural stimulation to restore volitional function previously lost due to spinal cord injury.
- Trial name
- NCT02592668
- Testing
- Epidural Stimulator
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic