Clinical trials: Spinal Paralysis
Spinal Cord Injury, Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI (WINY)
This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT07222033
- Testing
- Hands-free exoskeleton
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Spinal Cord Injury
Restoration of Upper Limb Function in Individuals With Sub-Acute Spinal Cord Injury
The objective of this research program is to conduct a multi-site clinical randomized control trial that will evaluate the efficacy of functional electrical stimulation based upper limb intervention for people with tetraplegia.
- Trial name
- MCRCT (NCT01292811)
- Testing
- Functional Electrical Stimulation (Compex Motion Stimulator), Conventional Occupational therapy
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Toronto Rehabilitation Institute
Spinal Cord Injuries, Paraplegia, Complete
Epidural Stimulation After Neurologic Damage
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement.
- Trial name
- E-STAND (NCT03026816)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Progressive Supranuclear Palsy, Spinal Cord Stimulation
The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy
The study is an open-label, prospective, single-arm, unicentral (Huashan Hospital Department of Neurology/ Neurosurgery) and exploratory clinical trial.
- Trial name
- NCT04367116
- Testing
- Spinal Cord Stimulation
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Huashan Hospital
Spinal Cord Injuries, Paraplegia
ExoAtlet II For SCI Patients
This study will evaluate the ExoAtlet II exoskeleton for safety and effectiveness of providing persons with a spinal cord injury (SCI) who are non-ambulatory or have limited ambulatory function, to stand up and ambulate under a…
- Trial name
- EXOATLET2SCI (NCT04215081)
- Testing
- Gait training using ExoAtlet exoskeleton
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- COSMO ROBOTICS CO., Ltd
Incomplete Spinal Cord Injury
The Use of Electromagnetic Field (EMF) Treatment in Chronic Spinal Cord Injury (SCI) Patients
The purpose of this study is to further establish safety and efficacy of the BQ EMF treatment of chronic SCI subjects who demonstrate stability in The Graded and Redefined Assessment of Strength, Sensibility and Prehension…
- Trial name
- NCT04050696
- Testing
- BQ 1.2
- Where
- 3 sites in United States, Israel
- Volunteers
- 8 people
- Sponsor
- BrainQ Technologies Ltd.
Spina Bifida, Cerebral Palsy
Medication Management Among Individuals With Neurodevelopmental Disabilities
This is a pilot study to develop a reinforcement learning (RL)-adaptive visual and interactive support application (hereafter RL-adaptive support) to help young adults with spina bifida or cerebral palsy become more independent…
- Trial name
- M-MIND (NCT03121651)
- Testing
- RL-adaptive application
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Michigan
Cerebral Palsy
tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy
This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy.
- Trial name
- NCT07433023
- Testing
- tSCS, 5-Azacitidine, Mannitol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab
Rare Diseases
European Registry on Rare Neurological Diseases
The recent implementation of European Reference Networks for Rare Diseases (ERNs) is an unprecedented move to improve the care of patients suffering from rare health disorders by transnational collaboration.
- Trial name
- ERN-RND reg (NCT04319796)
- Testing
- Data set as defined by the ERN Research Workgroup of the European Commission
- Volunteers
- 5,000 people
- Sponsor
- University Hospital Tuebingen
Spinal Cord Injury, Tetraplegia
Conditioning Neural Circuits to Improve Upper Extremity Function
Non-invasive brain stimulation has gained increasing popularity and research support over the past several years. Recent research indicates that it might have benefits for improving hand function in people with spinal cord…
- Trial name
- NCT02611375
- Testing
- transcranial direct current stimulation, peripheral nerve somatosensory stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shepherd Center, Atlanta GA
Spinal Cord Injuries, Tetraplegia
Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI)
This study will evaluate if Ursolic Acid supplementation may be effective in reducing muscle loss and improving blood sugar control in the SCI community.
- Conditions
- Spinal Cord Injuries, Tetraplegia, Paraplegia, Muscle Loss
- Trial name
- NCT05776862
- Testing
- Ursolic Acid, Strength Training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Spinal Cord Injuries, Tetraplegia
MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury
The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.
- Trial name
- NCT05553457
- Testing
- Testing of MyHand-SCI Device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Spinal Cord Injury, Tetraplegia
Effects of Exercise in People With Tetraplegia
This study is designed to assess the impact of exercise and supplementation on measures of fitness, function, and cardiovascular disease risk factors/modifiers in individuals with spinal cord injury (SCI).
- Trial name
- NCT01202019
- Testing
- Circuit Resistance Training (CRT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Tetraplegia, Locked-in Syndrome
Investigation on the Cortical Communication (CortiCom) System
The CortiCom system consists of 510(k)-cleared components: platinum PMT subdural cortical electrode grids, a Blackrock Microsystems patient pedestal, and an external NeuroPort Neural Signal Processor.
- Conditions
- Tetraplegia, Locked-in Syndrome, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- CortiCom (NCT03567213)
- Testing
- Surgical implantation of CortiCom system
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Autism Spectrum Disorder, Cerebral Palsy
READYorNot[TM] Brain-Based Disabilities Trial
The purpose of this study is to find out if there is a benefit to using the MyREADY Transition[TM] BBD App for brain-based disabilities, compared to not using it.
- Conditions
- Autism Spectrum Disorder, Cerebral Palsy, Epilepsy, Fetal Alcohol Spectrum Disorders
- Trial name
- NCT03852550
- Testing
- e-health application
- Where
- 9 sites in Canada
- Volunteers
- 52 people
- Sponsor
- McMaster University
Spinal Cord Injuries, Paraplegia, Spinal
Activity-Dependent Transspinal Stimulation in SCI
Robotic gait training is often used with the aim to improve walking ability in individuals with Spinal Cord Injury. However, robotic gait training alone may not be sufficient.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
- Trial name
- NCT03669302
- Testing
- Robotic gait training, Robotic gait training and low-frequency transspinal stimulation, Robotic gait training and high-frequency transspinal stimulation
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- City University of New York
Spinal Cord Diseases, Spinal Cord Injuries
Optimization of Adaptive Rowing Seating
Adaptive sports programs are integral components to combating Veteran isolation, promoting wellbeing and seeking to build teams, networks, communities.
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neurodegenerative Disorders, Cerebrovascular Accident With Associated Sequelae
- Trial name
- OARS (NCT07099625)
- Testing
- Adaptive Indoor Rowing Seat, Paddle Sport adaptive seating system
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Incomplete Spinal Cord Injury, Muscular Dystrophy
Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders
Background: Cerebral palsy (CP) is the most common motor disorder in children. CP often causes crouch gait, an abnormal way of walking. Knee crouch has many causes, so no single device or approach works best for everybody.
- Conditions
- Incomplete Spinal Cord Injury, Muscular Dystrophy, Spina Bifida, Cerebral Palsy
- Trial name
- NCT01961557
- Testing
- EA-KAFO
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Spasticity as Sequela of Stroke, Stroke
Transcutaneous Spinal and Peripheral Stimulation and Wrist Robotic Therapy for Patients With Spastic Stroke
The purpose of this study is to investigate if two courses of five consecutive sessions of noninvasive spinal stimulation paired with peripheral nerve stimulation at the forearm provided by an investigational device (Doublestim™/…
- Conditions
- Spasticity as Sequela of Stroke, Stroke, Stroke Sequelae, Hemiplegia, Spastic
- Trial name
- NCT04113525
- Testing
- MyoRegulator™ System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Northwell Health
Spinal Cord Injury
Cethrin in Acute Cervical Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III study designed to evaluate the efficacy and safety of Cethrin as a treatment for acute cervical spinal cord injury.
- Trial name
- NCT02053883
- Testing
- Cethrin (BA-210)
- Sponsor
- BioAxone BioSciences, Inc.