Clinical trials: Spinal Plasticity
Cervical Spinal Cord Injury
Linking Brain to Behaviour Research in SCI
Introduction In recent years, client-centred and task-oriented training have emerged as important methods in rehabilitation including the rehabilitation of persons with spinal cord injury (SCI).
- Trial name
- NCT01963026
- Testing
- ToCUEST featuring a 'variable practice' approach., ToCUEST featuring a 'constant practice' approach.
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Adelante, Centre of Expertise in Rehabilitation and Audiology
Spinal Cord Injuries, Upper Extremity Paresis
Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries
Texas Biomedical Device Center at UT Dallas has developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury termed targeted plasticity therapy (TPT).
- Trial name
- NCT04288245
- Testing
- Active Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Healthy Control, Spinal Cord Injury
Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury
This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control.
- Trial name
- NCT07814313
- Testing
- CST PAS, RST PAS
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Randomized Controlled Trial on Robotic Exoskeleton in Spinal Cord Injury: Clinical Outcomes and Cortical Plasticity
The recent introduction of robotics for locomotor training in paraplegic patients, and in particular the use of anthropomorphic exoskeletons, has opened new frontiers in rehabilitation.
- Trial name
- NCT03443700
- Testing
- EKSO-GT, Standard neurorehabilitation locomotor training
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Usl di Bologna
SCI
AIH for Spinal Cord Repair
Contusive cervical spinal cord injury (cSCI) impairs upper limb function (reach-and-grasp) which limits daily-life activities and thus decreases the quality of life.
- Trial name
- NCT03780829
- Testing
- hypoxia, D-cycloserine, exercise training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Quadriplegia
Retraining Walking After Spinal Cord Injury
Incomplete spinal cord injury often results in difficulty walking. Training on a treadmill with body weight support may improve walking ability after spinal cord injury.
- Conditions
- Spinal Cord Injuries, Quadriplegia, Paraplegia, Central Cord Syndrome
- Trial name
- NCT00059553
- Testing
- Locomotor treadmill training with body weight support
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Parkinson Disease
Exercise and Plasticity in Parkinson Disease
We will study the effects of intensive rehabilitation in PD on plasticity with a multimodal approach. We will define first, whether exercise in PD restores the potentiation of the motor cortex to normal levels with both 5 Hz-rTMS…
- Trial name
- NCT05786261
- Testing
- experimental group MIRT, EEG task rTMS, fMRI
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Sleep Apnea, Obstructive, Spinal Cord Injuries
Motor Plasticity, Intermittent Hypoxia and Sleep Apnea
The purpose of this study is to learn about the effect of sleep apnea and low oxygen on muscle strength and lung function in people with chronic spinal cord injury.
- Conditions
- Sleep Apnea, Obstructive, Spinal Cord Injuries, Hypoxia
- Trial name
- NCT04017767
- Testing
- Induced Acute Intermittent Hypoxia (AIH), AIH mask
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Spinal Cord Injury
Improving Hand and Arm Function After Spinal Cord Injury (SCI)
The long-term goal of this project is to develop rehabilitation strategies that facilitate optimal restoration of skilled hand use in individuals with spinal cord injury (SCI).
- Trial name
- NCT01143597
- Testing
- Arm and hand training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Miami
Multiple Sclerosis, Parkinson Disease
Biomarkers of Synaptic Damage in Multiple Sclerosis
A prospective and retrospective cohort study of about five years will be performed on blood and cerebrospinal fluid samples taken for diagnostic reasons from recruited patients within the Neuromed Neurology Unit.
- Conditions
- Multiple Sclerosis, Parkinson Disease, Amyotrophic Lateral Sclerosis, Alzheimer Disease
- Trial name
- NCT03217396
- Testing
- lumbar puncture
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Neuromed IRCCS
Spinal Cord Injuries
Recovery of Bladder and Sexual Function After Spinal Cord Injury
Bladder and sexual dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury.
- Trial name
- NCT03036527
- Testing
- Activity-based locomotor training, Activity-based stand training, Activity-based upper arm ergometry
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Healthy
Nerve Stimulation to Modify a Spinal Reflex
This study will determine whether stimulating the nerves or the brain can modify the spinal reflex that controls the muscles that flex and extend the ankle.
- Trial name
- NCT00039819
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Diseases
Reorganization of Brain Functions in Patients With Cervical Myelopathy Using fMRI and MRS
Decompressive surgery to relieve symptoms of spinal cord compression due to dysfunction, such as arthritis, has proved variable in success.
- Trial name
- NCT00447343
- Testing
- Decompressive cervical spine surgery, fMRI and MRS scan
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Spinal Cord Injuries, Motor Disorders
DiSCIoser: Improving Arm Sensorimotor Functions After Spinal Cord Injury Via Brain-Computer Interface Training
The goal of this clinical trial is to validate the efficacy of a Brain-Computer Interface (BCI)-based intervention for hand motor recovery in subacute cervical spinal cord injured (SCI) patients during rehabilitation.
- Trial name
- DiSCIoser (NCT05637775)
- Testing
- EEG-based BCI system for (hands) Motor Imagery training, Control - MI intervention
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Spinal Cord Injuries, Non Invasive Spinal Stimulation
Development of a Novel Strategy to Analyze the Effect on Gait Using Transcutaneous Spinal Current Stimulation in Incomplete Spinal Cord Injured Patients
To determine whether the combination of non-invasive spinal cord stimulation together with gait rehabilitation reduces spasticity and facilitates recovery of lower limb motor strength and gait function in patients with incomplete…
- Conditions
- Spinal Cord Injuries, Non Invasive Spinal Stimulation, Gait Disorders, Neurologic, Motor Function; Retardation
- Trial name
- NCT07289191
- Testing
- transcutaneous spinal cord stimulation
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Institut Guttmann
Spinal Cord Injury
Effects of System Suspended Robotic Lokomat Gait in Patients With Incomplete Spinal Cord Injury
Patients with incomplete spinal cord injury
- Trial name
- NCT02342080
- Testing
- Training sessions, Lokomat system (Hocoma AG Switzerland)
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic
BCI-Assisted SCS-EXS for Gait Optimization
The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury…
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic, Spinal Cord Injury, Spinal Cord Injury Cervical
- Trial name
- BASEGO (NCT06939660)
- Testing
- BCI-SCS-EXS
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Cerebrovascular Accident
Spinal Plasticity to Enhance Motor Retraining After Stroke
The objective of this project is to study the effects of an emerging noninvasive neuromodulation strategy in human stroke survivors with movement-related disability.
- Conditions
- Stroke, Cerebrovascular Accident, Hemiparesis
- Trial name
- NCT03645122
- Testing
- Paired corticospinal-motoneuronal stimulation (PCMS)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Movement Disorders, Parkinson Disease
Non-invasive Assessment of Synaptic Plasticity
The pathophysiological mechanisms underlying Movement Disorders, including Parkinson's disease, have been related to altered synaptic plasticity affecting several structures of the central nervous system.
- Trial name
- NEUROPLAST (NCT05353517)
- Testing
- Device: focal muscle vibration and theta burst stimulation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Spinal Plasticity
Combining PAS to Non-invasive VNS
Vagus nerve stimulation (VNS) and paired associative stimulation (PAS) have been shown to have efficacy in improving the results of motor rehabilitation after stroke and spinal cord injury, respectively.
- Trial name
- NCT04938284
- Testing
- PAS, VNS
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital