Clinical trials: Spinal Plasticity
Spinal Cord Injury (SCI)
FLO2 for Recovery After SCI
Acute intermittent hypoxia (AIH) involves short (~1-2min) bouts of breathing low oxygen air to stimulate spinal neuroplasticity.
- Trial name
- NCT03833674
- Testing
- Daily AIH Block, Respiratory Strength Training Block, AIH + Strength Training Block
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Investigating Spinal Atrophy in Patients With Spinal Injury
Plasticity of Grey and White Matter in Response to Motor Skill Training in Healthy Individuals and Those With Spinal Cord Injury
We aim to investigate the effect of motor skill training of the upper and lower limbs on the function and structure of the CNS as measured by neuroimaging parameters sensitive to changes in tissue volume and density and the…
- Trial name
- NCT02148887
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injuries
Non-Invasive Spinal Cord Stimulation After Injury
The goal of this study is to assess the function of the lungs and the muscles are used to breathe after individuals receive respiratory training, spinal cord stimulation, a combination of respiratory training and stimulation, a…
- Trial name
- NCT03998527
- Testing
- Transcutaneous Electrical Spinal Cord Stimulation (TcESCS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Healthy
Spinal Cord Plasticity
This study will examine the role of the spinal cord in improving leg movements after physical training in healthy people. The results of this study may be helpful in developing new rehabilitation therapies for people with…
- Trial name
- NCT00073606
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries (SCI)
Hypoxia Pathways for Early Recovery After Spinal Cord Injury
Spinal cord injury (SCI) disrupts neural pathways to respiratory motor neurons, diminishing breathing capacity and airway defense (e.g., cough).
- Trial name
- HyPER-FLO (NCT07002437)
- Testing
- Augmented Acute Intermittent Hypoxia (aAIH), Acute Intermittent Hypercapnic-Hypoxia (AIHH)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Spinal Cord Injuries, Neuralgia
Long-term Effects of Repetitive TMS in Chronic Neuropathic Pain in People With SCI
Around 80% of people with spinal cord injury (SCI) develop chronic neuropathic pain (CNP). This is a debilitating condition with major negative impacts on people's quality of life.
- Conditions
- Spinal Cord Injuries, Neuralgia, Chronic Pain
- Trial name
- NCT05226676
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis
Spinal Cord Associative Plasticity Study
Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis, Cervical Myelopathy
- Trial name
- SCAP (NCT05163639)
- Testing
- Non-invasive pairing of cortical and spinal stimulation, Intraoperative pairing of cortical and spinal stimulation, Non-invasive repeated pairing of cortical and spinal stimulation (SCAP)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Columbia University
Spinal Cord Injuries
Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI
This study uses Magnetic Resonance Imaging to image the brain and spinal cord before and after an Intermittent Hypoxia intervention.
- Trial name
- NCT05183113
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Spinal Cord Injuries, Cervical Spinal Cord Injury
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in…
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Respiratory Function Impaired
- Trial name
- NCT05756894
- Testing
- Neurostimulation, Repiratory training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries, Spine Disease
Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI
The investigators are conducting a research study to try to improve rehabilitation interventions for individuals with spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries, Spine Disease, Stroke
- Trial name
- NCT05589402
- Testing
- Lidocaine Cream 5%, Rehabilitation Movement Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas Rio Grande Valley
Cerebrovascular Disorders, Healthy
Non-Invasive Electrical Stimulation of the Human Brain
This study is designed to allow researchers to use transelectrical stimulation to explore the function of the human nervous system and improve diagnosis of neurological disorders.
- Conditions
- Cerebrovascular Disorders, Healthy, Nervous System Diseases, Spinal Cord Injuries
- Trial name
- NCT00001216
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries
Novel Intervention to Influence Muscle Plasticity in Veterans
The loss of muscle contraction (paralysis) removes an important stimulus for maintenance of overall health for individuals with complete spinal cord injury (SCI).
- Trial name
- NCT01093014
- Testing
- Low-force muscle stimulation, High-force muscle stimulation, Sequential low-force and high-force muscle stimulation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Cerebral Stroke, Traumatic Brain Injury
Telerehabilitation Early After CNS Injury
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI).
- Conditions
- Cerebral Stroke, Traumatic Brain Injury, Spinal Cord Injuries
- Trial name
- NCT06069999
- Testing
- HandyMotion Treatment Program
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- TRCare, Inc.
Spinal Cord Injuries
Neural Plasticity and Motor Recovery After Upper Extremity Motor Training in People With c-SCI
After spinal cord injury (SCI), there is a disruption in neural circuits resulting in paralysis. There is not yet a cure for paralysis.
- Trial name
- REPAIR-SCI (NCT06065384)
- Testing
- experimental group: intensive motor training, usual care
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 44 people
- Sponsor
- Annemie Spooren
Hemiplegic Cerebral Palsy
Spinal Cord Associative Plasticity in Cerebral Palsy
Associative plasticity has been used to promote functional recovery from conditions affecting movement. The long term goal of this project is to use electrical stimulation techniques to improve arm and hand function.
- Trial name
- SCAP-CP (NCT07607665)
- Testing
- Paired brain and nerve stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Columbia University
Cerebrovascular Disorder, Healthy
Magnetic Resonance Imaging Studies of Motor and Thought Processes
Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation).
- Conditions
- Cerebrovascular Disorder, Healthy, Movement Disorder, Nervous System Disease
- Trial name
- NCT00001361
- Where
- United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries, Neuropathic Pain
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
- Trial name
- NCT05492188
- Testing
- Operant Conditioning of Cutaneous Reflexes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injury
Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury
The Ibuprofen - Spinal Cord Injury (SCI) - Safety trial investigates tolerability and feasibility of "small molecule" (Ibuprofen) mediated Rho-inhibition as putative neuroprotective, plasticity-enhancing and neurorestaurative…
- Trial name
- NCT02096913
- Testing
- Dolormin® extra (Ibuprofen)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Jan M. Schwab, MD, PhD
Healthy
Spinal Reflexes in Motor Skill Learning
This study will test a spinal cord reflex called reciprocal inhibition before, during, and after learning a motor skill to see if the reflex becomes stronger by learning the movement.
- Trial name
- NCT00076583
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)