Clinical trials: Spinal Puncture Complications
Postdural Puncture Headache, Cerebrospinal Fluid Leak
Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
The SNOB study is a prospective, randomized, double-blind, placebo-controlled, cross-over pragmatic trial that has been designed in accordance with the CONSORT guidelines.
- Conditions
- Postdural Puncture Headache, Cerebrospinal Fluid Leak, Spinal; Puncture, Complications, Headache
- Trial name
- SNoB (NCT03181464)
- Testing
- Lidocaine 4%
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Stress, Emotional, Spinal; Puncture, Complications, Headache
Acute Mental Stress During Lumbar Puncture
This study explores lumbar puncture operators stress associated with their performance of the procedure, across three experience levels: Experts, Intermediates, and Novices.
- Conditions
- Stress, Emotional, Spinal; Puncture, Complications, Headache, Lumbar Puncture
- Trial name
- NCT03192423
- Where
- 3 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal and Epidural Anaesthesia-Induced Headache During Pregnancy
Establishment of a Predictive Model for Post-dural Puncture Headache
The goal of this clinical trial is to establish a predictive model for post-dural puncture headache. The main questions it aims to answer are: Changes in intracranial pressure after spinal puncture (or lumbar puncture).
- Trial name
- NCT06800859
- Testing
- Supplement fluids
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Yilin Zhao
Postdural Puncture Headache, Postoperative Nausea and Vomiting
Ondansetron and Dexamethasone for Prevention of PDPH, Nausea, and Vomiting
This prospective, randomized, double-blind, placebo-controlled study was conducted at the Obstetrics and Gynecology Department of El-Minia University Hospital from October 2018 to October 2019.
- Conditions
- Postdural Puncture Headache, Postoperative Nausea and Vomiting, Obstetric Anesthesia Problems
- Trial name
- PDPH-N/V (NCT07068230)
- Testing
- Ondansetron 8mg, Dexamethasone, Saline
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Post-Dural Puncture Headache
Optic Nerve Sheath Diameter in Postspinal Headache
This study aims to investigate the relationship between spinal needle size and optic nerve sheath diameter (ONSD) in patients who develop post-dural puncture headache (PDPH) after spinal anesthesia.
- Trial name
- PDPHPatients (NCT06957899)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Konya City Hospital
Spinal Puncture Complications, Simulation-based Training
The Effect of Simulation-Based Training on Performance and Stress in the Clinical Setting
This study will investigate the effect of simulation-based training with mastery learning (SBML) on novice performers' lumbar puncture (LP) performance in a clinical setting.
- Conditions
- Spinal Puncture Complications, Simulation-based Training, Stress, Emotional
- Trial name
- NCT03163927
- Testing
- Simulation-based training
- Where
- 3 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infection, Candida
Early Diagnosis of Candidiasis in Premature Infants
This observational study evaluated the performance of new lab tests in detecting candida species fungal infections in extremely low birth weight (ELBW) infants quickly and accurately.
- Conditions
- Infection, Candida, Candidiasis, Infant, Newborn
- Trial name
- Candida (NCT00109525)
- Where
- 20 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Cesarean Section Complications
Ultrasonographic ONSD as a Predictor of PDPH in Spinal Anesthesia for Cesarean Delivery
The Optic Nerve Sheath Diameter (ONSD), measured non-invasively by bedside ultrasound, is a well-established surrogate for intracranial pressure (ICP), as the optic nerve sheath is continuous with the intracranial dura mater and…
- Trial name
- NCT07360756
- Testing
- Study Cohort (Single Cohort)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Al-Azhar University
Spinal Puncture Complications
Management Following Lumbar Puncture In Children
The study is carried out in a prospectively randomly controlled way. In the context of acknowledgement and understanding from parents, by comparing with traditional process (lying without the pillow and fasting water and food for…
- Trial name
- MFLPIC (NCT02590718)
- Testing
- optimized postoperative management
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Normal Pressure Hydrocephalus
Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH
Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. Urinary symptoms in normal pressure hydrocephalus are mainly represented by overactive bladder, which…
- Trial name
- PLHPN (NCT03877107)
- Testing
- Urinary symptoms profile questionnaire, Micturition calendar
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- EssaiClinique_PL-HPN
Anesthesia; Adverse Effect, Spinal and Epidural, Headache, Complications; Anesthesia, Spinal and Epidural, in Pregnancy
Comparison of Two Spinal Needles Regarding Postdural Puncture Headache
The aim of the study is to observe the rate of postdural puncture headache observed after spinal anesthesia in cesarean section patients. Two kind of spinal anesthesia needles will be used: 1.
- Trial name
- NCT01821807
- Where
- Turkey (Türkiye)
- Volunteers
- 256 people
- Sponsor
- Adiyaman University Research Hospital
Spinal Puncture Complications
Optimization Lumbar Puncture In Children
The study is carried out in a prospective randomized controlled way. In the context of informed understanding from parents, compared with traditional process(no anesthesia; lying without the pillow and fasting water and food for…
- Trial name
- OLPIC (NCT02454894)
- Testing
- lidocaine, postoperative management
- Sponsor
- Beijing Children's Hospital
Anesthesia, Spinal, Spinal Puncture Complications
Ultrasound-assisted or Landmark-based Intrathecal Administration of Nusinersen in Adult Patients With Spinal Muscular Atrophy (The EchoSpin Study)
Nusinersen (Spinraza, Biogen Inc, Boston, MA), the first treatment approved by FDA and EMA for all Spinal Muscular Atrophy (SMA) subtypes, is an antisense oligonucleotide that is administered intrathecally through a lumbar…
- Conditions
- Anesthesia, Spinal, Spinal Puncture Complications, Spinal Muscular Atrophy, Ultrasonography
- Trial name
- EchoSpin (NCT05644899)
- Testing
- Interlaminar ultrasound-assisted intrathecal administration of nusinersen, Landmark-based intrathecal administration of nusinersen
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Spinal; Puncture, Complications
Ultrasound vs Palpation for Infant Lumbar Puncture
The purpose of this study is to determine if performing an ultrasound to identify the space to insert the needle before performing a lumbar puncture will improve success of the procedure and patient safety.
- Trial name
- NCT02373774
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Columbia University
Ultrasound Therapy; Complications
Utility of Ultrasound-Guided Site Marking in Pediatric Lumbar Punctures
The standard way to identify landmarks in the spine before inserting a needle for a lumbar puncture is to feel by touch. The purpose of this research is to determine if doing an ultrasound to identify landmarks before performing…
- Trial name
- NCT04828746
- Testing
- Ultrasound Guided Skin Marking
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Lumbar Puncture
Ultrasound-assisted vs Palpation-guided Lumbar Punctures
The goal of this randomized clinical trial is to determine whether ultrasound-assisted lumbar puncture improves first-needle insertion success compared with the standard palpation technique in adults undergoing a clinically…
- Trial name
- NCT07824284
- Testing
- Ultrasound-Assisted Lumbar Puncture, Standard Palpation-Guided Lumbar Puncture
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- The Cooper Health System