Clinical trials: Spine, Open
Bone Loss, Spinal Cord Injuries
Intervention on Bone Health in Wheelchair Users
The low mechanical loading of bones among wheelchair users leads to an increased risk of bone fractures and associated complications due to low bone mineral density (BMD).
- Conditions
- Bone Loss, Spinal Cord Injuries, Cerebral Palsy, Spina Bifida
- Trial name
- BoneWheel (NCT05615402)
- Testing
- Bone-specific strength training, Nutrition optimalisation
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Spina Bifida
Evaluation of Depression and Anxiety Levels of Parents of Children with Spina Bifida
Studies in the literature have measured the anxiety and depression levels of parents of children with spina bifida. Additionally, it has been reported that parents of children with non-neurogenic lower urinary tract dysfunction…
- Trial name
- NCT06802770
- Testing
- Anxiety, Depression levels
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University
Osteoarthritis of the Lumbar Spine, Pain, Back
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis of the Lumbar Spine
This is a Phase 3, Multicenter, Randomized, 22 Week, Double-Blind, Placebo Controlled and 3-Week, Open-Label Study to Evaluate the Efficacy and Safety of X0002 Spray in relief of the signs and symptoms of Subjects with…
- Trial name
- NCT03110523
- Testing
- X0002
- Sponsor
- Techfields Pharma Co. Ltd
Radiation Therapy, Bone Metastases
Stereotactic Multiple Fraction Radiotherapy for Non-spine Bone Metastases
To investigate, whether multi-fraction stereotactic body radiation therapy (SBRT) within 3 treatment fractions is non-inferior to the current standard of care of 5 fraction SBRT regarding pain response at 3 months after…
- Conditions
- Radiation Therapy, Bone Metastases, Pain
- Trial name
- SMILE (NCT05406063)
- Testing
- SBRT
- Where
- 2 sites in Switzerland
- Volunteers
- 162 people
- Sponsor
- Kantonsspital Winterthur KSW
Lumbar Disk Herniation
Percutaneous Transforaminal Endoscopic Discectomy vs. Open Microdiscectomy for Lumbar Disc Herniation (PTED-study)
Rationale: Lumbosacral radicular syndrome (LSRS) is caused by a herniated lumbar nucleus pulposus (HNP) and the estimated annual incidence in The Netherlands ranges between 60,000 to 75,000 people.
- Trial name
- NCT02602093
- Testing
- Transforaminal Endoscopic Discectomy, Open Microdiscectomy
- Where
- Netherlands
- Volunteers
- 682 people
- Sponsor
- Amsterdam UMC, location VUmc
Spinal Cord Injury, Spina Bifida
Virtual Reality Based Testing of Power Wheelchair Driving Skills
The purpose of this research study is to examine whether computer based or virtual reality based driving assessments are as useful as real-world power wheelchair driving tests in measuring driving performance and whether they may…
- Conditions
- Spinal Cord Injury, Spina Bifida, Spinal Cord Disease
- Trial name
- NCT00951509
- Testing
- Power Mobility Road Test (PMRT)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- US Department of Veterans Affairs
Osteoporosis
Transition From Alendronate to Romosozumab (AMG 785)
The purpose of this study is to estimate the percent change from baseline in lumbar spine bone mineral density (BMD) following multiple-dose administrations of romosozumab in postmenopausal women with low BMD previously treated…
- Trial name
- NCT01588509
- Testing
- Romosozumab
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Amgen
Sacroiliitis, Sacroiliac; Fusion
Evaluation of the iFuse Bedrock Technique in Association With Posterior Lumbosacral Fusion With Iliac Fixation.
The purpose of this study is to describe the impact of the iFuse Bedrock technique to decrease post-operative pains in patients who underwent multilevel posterior lumbosacral fusion.
- Conditions
- Sacroiliitis, Sacroiliac; Fusion, Lumbosacral; Fusion, Spine Deformity
- Trial name
- NCT05276024
- Testing
- iFuse Bedrock technique
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- Polyclinique Bordeaux Nord Aquitaine
Spina Bifida or Spinal Dysraphism
Vitamin B9 Supplementation Recommendations in Rennes CHU
The study objective is to assess the knowledge and the follow-up of vitamin B9 supplementation recommendations for women in the periconceptional period to prevent neural tube closure defects.
- Trial name
- QUALI B9 (NCT04195542)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 1,284 people
- Sponsor
- Rennes University Hospital
Neurogenic Bladder Disorder, Bladder Dysfunction
Urinary Artificial Sphincter in Children
Retrospective monocentric study of the outcomes of patients with neurogenic bladder who had a urinary artificial sphincter before the age of 18 years old.
- Conditions
- Neurogenic Bladder Disorder, Bladder Dysfunction, Spina Bifida, Urinary Incontinence Due to Urethral Sphincter Incompetence
- Trial name
- SUAPED (NCT06734429)
- Testing
- Urinary Artificial Sphincter
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Clermont-Ferrand
Thoracolumbar; Spina Bifida
3D-printed Module-assisted Minimally Invasive Lumbar Pedicle Screw Placement
To explore the accuracy of 3D printed module assisted minimally invasive lumbar pedicle screw placement using Quandrant system, and verify its feasibility of reducing error rate of screw placement and postoperative complications.
- Trial name
- NCT02970578
- Testing
- 3D printed module
- Volunteers
- 36 people
- Sponsor
- The Affiliated Hospital of Putian University
Fetal Anomaly, Spinal Dysraphism
An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience
Brain stem and posterior fossa measurements in spina bifida aperta fetuses to compare them with normal population. Additionally, Describe the difference between pre- and postoperative findings.
- Conditions
- Fetal Anomaly, Spinal Dysraphism, Chiari Malformation Type 2
- Trial name
- NCT03544970
- Where
- Belgium
- Volunteers
- 316 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spine Surgery
An Open, Parallel-group, Randomized, Medical Device Study to Assess the Usability and Performance of Surgify HaloTM in Spine Surgery Versus State-of-art (Rosen Burr)
The purpose of this research study is to: test the usability and performance of the medical device Surgify Halo ™ in spine surgery test the level of "chattering " during the use of the device test the cutting performance of…
- Trial name
- NCT06827795
- Testing
- A burr used in spine surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Surgify Medical Oy
Neurologic Disorder, Parkinson Disease
High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners
Individuals with and without neurologic diagnoses greatly benefit from participation in regular exercise but the majority are physically inactive.
- Conditions
- Neurologic Disorder, Parkinson Disease, Spinal Cord Injuries, Spina Bifida
- Trial name
- SHIFT-AR (NCT05951985)
- Testing
- HIFT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Arkansas Colleges of Health Education
Neurogenic Bladder, Spina Bifida
Comparing Urinary Tract Infections in Children With Spina Bifida Using Two Types of Catheters for Catheterization
The primary aim of this study was to determine if using the SpeediCath hydrophilic catheter would reduce the incidence of symptomatic urinary tract infections (UTI)in children with spina bifida who perform clean intermittent…
- Trial name
- NCT01263392
- Testing
- Intermittent catheterization
- Where
- 4 sites in Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cerebral Palsy, Spina Bifida
The Effects of a Powered Knee Orthosis on Gait Kinematics of Children With Knee Extension Deficiency
Crouch gait/walking, characterized by an 'over-flexed' knee when the leg is supporting body weight, is common in children with diagnoses of cerebral palsy, spina bifida and other incomplete spinal cord injuries.
- Conditions
- Cerebral Palsy, Spina Bifida, Spinal Cord Injuries
- Trial name
- NCT05330052
- Testing
- Agilik
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of British Columbia
Complications of Surgical Procedure, Neurogenic Bladder
Complications of Enterocystoplasty in Children
The goal of this observational study is to describe the complications in participants who underwent enterocystoplasty in childhood.
- Conditions
- Complications of Surgical Procedure, Neurogenic Bladder, Spina Bifida, Child, Only
- Trial name
- AVPED (NCT05840874)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Dr Christelle DESTINVAL
Spinal Cord Injury, Spinal Cord Involvement
Clinical Trial of a Serious Game for Individuals With SCI/D
This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury…
- Conditions
- Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis
- Trial name
- NCT02341950
- Testing
- SCI Hard
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan
Fibrolipoma of Filum Terminale, Lipomyelomeningocele
Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence
Purpose of study : to determine the preventive effect of acetazolamide administration, prone positioning, and the combination of both following the neurosurgical interventions in lumbosacral region for cerebrospinal fluid (CSF)…
- Conditions
- Fibrolipoma of Filum Terminale, Lipomyelomeningocele, Split Cord Malformation, Dermal Sinus
- Trial name
- NCT01867268
- Testing
- Acetazolamide, prone positioning, Acetazolamide+ prone positioning
- Where
- Iran
- Volunteers
- 144 people
- Sponsor
- Tehran University of Medical Sciences
Spinal Surgery, Vascular Surgery
Immunogenicity and Safety Study of Topical Recombinant Thrombin in Surgical Hemostasis
The purpose of this study is to evaluate the safety and immune system response to recombinant thrombin when used to control bleeding in spinal and vascular surgery.
- Trial name
- NCT00491608
- Testing
- rThrombin
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- ZymoGenetics