Clinical trials: Spine, Open
Degenerative Scoliosis, Scoliosis Idiopathic
Spinal Bracing in Adults With Painful Degenerative Scoliosis: a Randomized Controlled Open Trial
The purpose of this study is to compare the efficacy on low back pain intensity at 6 months after randomization of a custom-molded lumbar-sacral orthosis as an add-on therapy to usual care in people with painful adult…
- Conditions
- Degenerative Scoliosis, Scoliosis Idiopathic, Thoracolumbar Scoliosis
- Trial name
- BRASCO (NCT06774898)
- Testing
- Custom-molded lumbar-sacral orthosis, Usual Care
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spine Surgery
SpinePal Open Pilot
SpinePal is a self-guided digital intervention developed for patients undergoing spine surgery. The goal of this study is to learn if SpinePal is acceptable to people undergoing spine surgery.
- Trial name
- NCT07737912
- Testing
- SpinePal
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Trustees of Dartmouth College
Neurogenic Bladder, Myelomeningocele
Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele
Patients with neurogenic bladder need periodic evaluation with urodynamic study, a invasive and uncomfortable procedure. Aim: To evaluate the accuracy of dynamic ultrasonography as a feasible and noninvasive alternative…
- Trial name
- NCT03550898
- Testing
- Dynamic Ultrasonography
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Spina Bifida
Effects of Progressive Resistance Exercise Training on Endurance and Functional Mobility in Children With Spina Bifida
In this research the effects of progressive resistance exercise training on endurance and functional mobility in children with spina bifida are assessed.
- Trial name
- NCT05719636
- Testing
- Conventional treatment, Progressive resistance exercise
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Osteoporosis, Postmenopausal, Osteoporosis
Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption
The objective of this study is to measure the early effects of abaloparatide on tissue-based bone formation using samples obtained by transiliac crest bone biopsy after quadruple fluorochrome labeling.
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis Vertebral, Osteoporosis Risk
- Trial name
- NCT03710889
- Testing
- Abaloparatide
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Radius Health, Inc.
Spina Bifida
Effectiveness of Biofeedback Training in Children with Neurogenic Bladder and Bowel Disorder Wıth Spina Bifida
The aim of this study is to examine and compare the bladder and bowel functions, activation of pelvic floor and abdominal muscle groups and quality of life of children diagnosed with spina bifida who did not receive any treatment…
- Trial name
- NCT06618378
- Testing
- Biofeedback exercise combined with breathing exercise, urotherapy educational group
- Volunteers
- 24 people
- Sponsor
- Hasan Kalyoncu University
Spina Bifida With Hydrocephalus
Impact of a Standing Program in a Child With Spina Bifida: A Case Report
The purpose of this case study is to investigate a child with MMC who has significant knee and hip flexion contractures to answer the following research questions: 1) Is a home standing program effective in reducing hip and knee…
- Trial name
- NCT05251740
- Testing
- Altimate Medical EasyStand Bantam
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of St. Augustine for Health Sciences
Lumbar Spine Degeneration
Study Using the SpinalStim Device Following Lumbar Fusion Surgery
This study examines the effect of adjunctive use of the SpinalStim bone growth stimulator on lumbar fusion rate in high risk subjects who have had lumbar fusion surgery.
- Trial name
- NCT03176303
- Testing
- SpinalStim
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Orthofix Inc.
Muscle Weakness, Problems Moving Their Arms and Legs
Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults
People with cerebral palsy (CP), muscular dystrophy (MD), spina bifida, or spinal cord injury often have muscle weakness, and problems moving their arms and legs.
- Trial name
- NCT06998134
- Testing
- Extension assist knee ankle foot orthosis (EA-KAFO)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Dural Sealing
DuraSeal Exact Spine Sealant System Post-Approval Study
This is a non-randomized, post-approval study to further evaluate the rate of post-operative Cerebral Spinal Fluid (CSF) leaks in subjects who undergo a spinal procedure and receive DuraSeal Exact Spine Sealant System.
- Trial name
- DuraSeal PAS (NCT01410864)
- Testing
- DuraSeal Exact Spine Sealant System, Control
- Where
- 36 sites in United States
- Volunteers
- 924 people
- Sponsor
- Integra LifeSciences Corporation
Deep Surgical Site Infection, Spine Surgery
Risk Factors Associated With Infection After Spine Surgery
Surgical site infection (SSI), particularly deep SSI, is one of the most serious complications after spinal surgery. evaluating the risk of SSI and, correspondingly, prescription of prophylactic measures are extremely important…
- Trial name
- NCT05740865
- Testing
- open posterior instrumented thoracolumbar surgery
- Where
- China
- Volunteers
- 3,419 people
- Sponsor
- Xuanwu Hospital, Beijing
Spina Bifida
Spina Bifida Healthcare Navigator Program
Many adults with spina bifida experience difficulties managing their health-such as coordinating care across multiple providers, keeping up with medications, and navigating insurance systems.
- Trial name
- ALIGN (NCT07531862)
- Testing
- Behavioral Treatment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pittsburgh
Open Spina Bifida, Myelomeningocele
Fetoscopic Open Spina Bifida Repair Using the SAFER Technique
Children submitted to fetoscopic in utero myelomeningocele repair using the SAFER (Skin-over-biocellulose for Anternatal FEtoscopic Repair) technique will evaluate at 30 months or more, regarding ambulation, neurodevelopment…
- Conditions
- Open Spina Bifida, Myelomeningocele, Meningomyelocele, Chiari Malformation With Spina Bifida
- Trial name
- NCT04356703
- Testing
- Neuropsicomotor developmental test
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital Israelita Albert Einstein
Spina Bifida, Cerebral Palsy
Medication Management Among Individuals With Neurodevelopmental Disabilities
This is a pilot study to develop a reinforcement learning (RL)-adaptive visual and interactive support application (hereafter RL-adaptive support) to help young adults with spina bifida or cerebral palsy become more independent…
- Trial name
- M-MIND (NCT03121651)
- Testing
- RL-adaptive application
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Michigan
Autism Spectrum Disorder, Cerebral Palsy
READYorNot[TM] Brain-Based Disabilities Trial
The purpose of this study is to find out if there is a benefit to using the MyREADY Transition[TM] BBD App for brain-based disabilities, compared to not using it.
- Conditions
- Autism Spectrum Disorder, Cerebral Palsy, Epilepsy, Fetal Alcohol Spectrum Disorders
- Trial name
- NCT03852550
- Testing
- e-health application
- Where
- 9 sites in Canada
- Volunteers
- 52 people
- Sponsor
- McMaster University
Neural Tube Defects - Spina Bifida and Anencephaly
Blood Folate and Homocysteine Levels Following Administration of Folic Acid According to Different Daily Dosing Schedules:a Simulation of Food Fortification
The aim of this study is to examine whether the same total daily dosage of folic acid, when taken as a single daily dose or as multiple divided doses throughout the day, results in different blood folate and homocysteine levels…
- Trial name
- NCT00207558
- Testing
- folic acid
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Incomplete Spinal Cord Injury, Muscular Dystrophy
Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders
Background: Cerebral palsy (CP) is the most common motor disorder in children. CP often causes crouch gait, an abnormal way of walking. Knee crouch has many causes, so no single device or approach works best for everybody.
- Conditions
- Incomplete Spinal Cord Injury, Muscular Dystrophy, Spina Bifida, Cerebral Palsy
- Trial name
- NCT01961557
- Testing
- EA-KAFO
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Prostate Cancer, Spine, Open
Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery
The primary endpoint of this study is the completion time of hemostasis treatment when administered Fresh frozen plasma (FFP) and frozen powder coagulation factor concentrate (PCC) in goal-directed bleeding management for…
- Conditions
- Prostate Cancer, Spine, Open, Hip Osteoarthritis, Knee Disease
- Trial name
- NCT06144099
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Meningomyelocele, Spinal Dysraphism
Management of Myelomeningocele Study (MOMS)
Spina bifida (myelomeningocele) is a complex birth defect in which a portion of the spinal cord is not fully developed. The overlying bones and skin are incompletely formed and the underdeveloped area of the spinal cord is…
- Trial name
- MOMS (NCT00060606)
- Testing
- Prenatal Myelomeningocele Repair Surgery, Postnatal Myelomeningocele Repair Surgery
- Where
- 3 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Neurogenic Bladder Due to Spina Bifida
Tibial Nerve Stimulation for Pediatric Spina Bifida Neurogenic Bladder
The purpose of this study is to determine the safety, feasibility, and compliance of a daily home transcutaneous tibial nerve stimulation (tTNS) protocol in children with chronic neurogenic bladder (NB) provided by self or…
- Trial name
- NCT07136688
- Testing
- Stamobil electric stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston