Clinical trials: Spine Injuries and Disorders, open to volunteers
Spinal Deformity, Spinal Degenerative Disorder
The Ailliance Post-Market Clinical Study
The purpose of this clinical study is to collect performance and safety data for post-market Medtronic devices indicated for cranial and/or spinal indication(s). Subjects are enrolled and followed postoperatively to 24 months.
- Conditions
- Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma
- Trial name
- NCT05856370
- Testing
- Follow-up schedule: pre-operative baseline up to 24-months post-procedure
- Where
- 29 sites in United States, France and 4 more
- Volunteers
- 1,000 people
- Sponsor
- Medtronic Spinal and Biologics
Spinal Cord Injuries, Spine Disease
Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe…
- Trial name
- NCT05473689
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University Health Network, Toronto
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Radius; Deformity, Hip Osteoarthritis
Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology
Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications.
- Conditions
- Radius; Deformity, Hip Osteoarthritis, Hip Arthritis, Hip Arthropathy
- Trial name
- NCT06603831
- Testing
- patients treated using 3D technology and Patient-Specific Instrumentation, Patients treated with conventional surgery, without using 3D technology
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Corporacion Parc Tauli
Spine Degeneration, Hip Arthritis
Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
This study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.
- Conditions
- Spine Degeneration, Hip Arthritis, Knee Osteoarthritis, Hip Fractures
- Trial name
- NCT06407427
- Testing
- App for in-bed conditioning exercises, Usual care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Mild Traumatic Brain Injury, Concussion
Psychologically Informed Cervicovestibular Rehabilitation (PIC Rehab) for Mild Traumatic Brain Injury: A Feasibility Trial
Mild traumatic brain injuries ("mTBIs") affect over 480,000 Canadians each year. While many individuals recover in the initial 4 weeks following mTBI, in up to 30% of individuals symptoms and functional impairments often persist…
- Trial name
- PIC Rehab (NCT07402733)
- Testing
- Psychologically Informed CVPT (PIC) Rehab, Cervicovestibular Rehabilitation (CVPT)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Sport Injury Prevention Research Centre
Degenerative Disc Disease, Craniocervical Injuries
Posterior Cervical Fixation Study
The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported…
- Conditions
- Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
- Trial name
- NCT04770571
- Testing
- observational study
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Spine Injury, Cord Injury, Spinal
The Outcome of Injured Cervical Spinal Cord With Uncontrolled Swelling Under Duraplasty
Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI).
- Conditions
- Spine Injury, Cord Injury, Spinal, Cord Infarction Spinal, Incomplete Spinal Cord Injury
- Trial name
- NCT06552507
- Testing
- Duroplasty
- Where
- Taiwan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cervical Spinal Cord Injury, Tetraplegia
Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation
Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots.
- Trial name
- UP2 (NCT05665998)
- Testing
- ARC-BSI Cervical system
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spine Health, Spine Injuries and Disorders
Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain
Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain.
- Conditions
- Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
- Trial name
- NCT07367139
- Testing
- Water
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milwaukee VA Medical Center
Spine Fracture, Osteoporosis
Controlled Reduction of AO Spine B3 Fractures in Ankylosing Spinal Disorders Using an Inflatable Positioning Device: Technical Note and Retrospective Single-centre Case Series
Retrospective observational
- Conditions
- Spine Fracture, Osteoporosis, Spondylitis, Ankylosing
- Trial name
- NCT07847320
- Volunteers
- 23 people
- Sponsor
- Diakonie-Klinikum Stuttgart
Spinal Cord Injury, Spinal Cord Injury Cervical
Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury
Stimulation of the spinal cord and brain represents a new experimental therapy that may have potential to restore movement after spinal cord injury.
- Trial name
- NCT06867809
- Testing
- Epidural spinal cord stimulation and paired spine and brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Jason Carmel
Neurologic Deficits
NeuroVision vs Standard Neuromonitoring
The purpose of this study is to perform a prospective, randomized, controlled clinical trial to assess the utility of IONM in patients undergoing primary, single or multilevel lateral spinal procedures.
- Trial name
- NCT04639297
- Testing
- NeuroVision® IONM, Hospital Based IONM
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Spine Injuries and Disorders
Which Markers of Musculoskeletal Health Can Explain Complications in Spinal Surgery?
The present study is related to the project "ORTHOSPINE FITNESS: WHICH MARKERS OF MUSCULOSKELETAL HEALTH CAN EXPLAIN COMPLICATIONS IN SPINE SURGERY?", winner of the Ministry of Health Call, financed by the European Union…
- Trial name
- NCT06736106
- Testing
- screening
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Ortopedico Rizzoli
Spinal Cord Injury
VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury
The purpose of this clinical study is to evaluate the preliminary safety and feasibility of using the VALSE system, which combines spinal cord stimulation with the TWIICE robotic exoskeleton, to support motor recovery and reduce…
- Trial name
- VALSE (NCT07745686)
- Testing
- TWIICE Rise 1.0 robotic exoskeleton combined with epidural electrical stimulation (EES)
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Abdominal Injury, Pelvic Fracture
Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients
Unrecognized abdominal and pelvic injuries can result in catastrophic disability and death. Sporadic reports of "occult" injuries have generated concern, and physicians, fearing that they may miss such an injury, have adopted the…
- Conditions
- Abdominal Injury, Pelvic Fracture, Genital Hemorrhage, Lumbar Spine Injury
- Trial name
- NEXUS AP CT (NCT04937868)
- Testing
- There are no interventions associated with this study
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- University of California, Los Angeles
Spine Fracture, Degenerative Disc Disease
Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical
Multicenter Post market clinical follow-up Study on the Safety and Performance of Ennovate® Cervical - Prospective, pure data collection of all Ennovate Cervical patients in Total Indications
- Conditions
- Spine Fracture, Degenerative Disc Disease, Spinal Instability, Spinal Tumor
- Trial name
- CERISE (NCT05296889)
- Testing
- posterior stabilization for the cervical spine
- Where
- 4 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Aesculap AG
Cervicogenic Headache, Whiplash Injuries
Manipulation and Dry Needling in Patients With Cervicogenic Headache and WAD II
The purpose of this research is to compare two different approaches for treating patients with cervicogenic headaches associated with type II whiplash associated disorder: non-thrust mobilization and exercise versus thrust…
- Trial name
- NCT06502951
- Testing
- Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Alabama Physical Therapy & Acupuncture