Clinical trials: Spine Metastases
Metastatic Cancer
Stereotactic Radiosurgery in Treating Patients With Spinal Metastases
RATIONALE: Stereotactic radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue. It may also help patients with spinal metastases live more comfortably.
- Trial name
- NCT00853528
- Testing
- questionnaire administration, diffusion tensor imaging, functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Boston Medical Center
Metastatic Cancer, Pain
Stereotactic Body Radiation Therapy and Vertebroplasty in Treating Patients With Localized Spinal Metastasis
RATIONALE: Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue.
- Conditions
- Metastatic Cancer, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00855803
- Testing
- radiation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Texas Southwestern Medical Center
Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Malignant Neoplasm in the Spine
Standard and Delayed FDG PET/CT After Chemoradiation Therapy in Assessing Patients With Metastatic Head and Neck Squamous Cell Cancer
This trial studies how well standard and delayed fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/computed tomography (CT) given after standard radiation and chemotherapy works in assessing patients with head and…
- Trial name
- NCT03575949
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Positron Emission Tomography
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Osseous Spine Metastases
Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR)
A randomized phase III study of palliative external beam radiotherapy (RTOG 97-14) has shown that 8 Gy in a single fraction is very effective in providing pain relief, with complete or partial improvement in pain seen in 66% of…
- Trial name
- NCT00267033
- Testing
- injection of orthopaedic cement into vertebral bodies
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer
This clinical trial evaluates the safety and feasibility of tumor treating fields (TTF) in the treatment of spinal leptomeningeal disease in patients with breast or lung cancer that has spread from where it first started (primary…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Malignant Neoplasm in the Leptomeninges, Metastatic Lung Carcinoma
- Trial name
- NCT05746325
- Testing
- Digital Photography, Lumbar Puncture, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Lumbar Spinal Stenosis Secondary to Other Disease
NanOss Bioactive With Autograft and Bone Marrow Aspirate in the Posterolateral Spine
The purpose of this study is to assess lumbar fusion using nanOss Bioactive bone void filler
- Trial name
- NCT02005341
- Testing
- nanOSS, Autograft
- Sponsor
- Pioneer Surgical Technology, Inc.
Bone Cancer Metastatic, Radiofrequency Ablation
Effectiveness Of Radiofrequency Ablation And Stabilization In Metastatic Spine Lesions By Positron Emission Computed Tomography (PET-CT) Confirmation
This pilot study will try to demonstrate metabolic changes in spine lesions treated by Augmentation and Ablation, according to existing standards of practice.
- Conditions
- Bone Cancer Metastatic, Radiofrequency Ablation, Spine Metastases, Vertebral Metastasis
- Trial name
- ABLASPINE (NCT06716294)
- Testing
- Radiofrequency Ablation and Bone Augmentation
- Where
- Greece
- Volunteers
- 16 people
- Sponsor
- National and Kapodistrian University of Athens
Neoplasm Metastasis
Stereotactic Body Radiotherapy Followed by Surgical Stabilization for Patients With Unstable Spinal Metastases
The aim of this study is to assess the feasibility and safety of combining stereotactic body radiotherapy (SBRT) and pedicle screw fixation in a 48-hour window for the treatment of painful unstable metastases of the thoracic…
- Trial name
- BLEND (NCT02622841)
- Testing
- BLEND
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- UMC Utrecht
Neoplasm Metastasis, Spinal Cord Diseases
Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases
The purpose of this research is to combine two complementary modes of treatment, spinal interstitial laser ablation and stereotactic spine radiosurgery (SSRS) for the treatment for spinal tumors near the spinal cord with an…
- Conditions
- Neoplasm Metastasis, Spinal Cord Diseases, Spinal Cord Compression, Spinal Cord Tumor
- Trial name
- NCT05023772
- Testing
- Stereotactic Laser Ablation, Stereotactic Radiosurgery, MRI guided laser ablation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Henry Ford Health System
Breast Cancer, Prostate Cancer
Potential Vertebroplasty Use in the Treatment of Vertebral Metastasis From Breast and Prostate Cancer
The study aims to evaluate if adding vertebroplasty to radiotherapy, in the treatment of spine metastasis from breast and prostate cancer, is preferable to radiotherapy alone.
- Conditions
- Breast Cancer, Prostate Cancer, Vertebral Metastasis, Pain
- Trial name
- NCT00294151
- Testing
- Vertebroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pain
Whole Versus Partial Vertebral Body IMRT for Spinal Metastases
To compare the treatment effect and toxicity between Intensity-Modulated Radiation therapy for whole metastatic vertebral body and simple metastatic lesions of vertebra in metastatic spinal tumors
- Trial name
- NCT02972229
- Testing
- 10x(3-5) Gy IMRT, 10x3 Gy IMRT
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Spinal Metastasis
Clinical Trial Comparing Dose-intensified SBRT With Conventional Radiation Therapy for Spinal Metastases
This study will compare pain (primary end-point) and local metastatic tumor control (secondary end-point) after dose-intensified image-guided fractionated stereotactic body radiation therapy (SBRT) for painful mass-type spinal…
- Trial name
- DOSIS RCT (NCT02800551)
- Testing
- dose-intensified image-guided SBRT using simultaneous integrated boost, External 3-dimensional conformal radiotherapy (3D-CRT)
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- University of Zurich
Degenerative Disc Disease, Spondylolisthesis
The European Robotic Spinal Instrumentation (EUROSPIN) Study
In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Recurrent Disc Herniation
- Trial name
- EUROSPIN (NCT03398915)
- Testing
- Transpedicular Instrumentation
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 932 people
- Sponsor
- Marc Schröder
Metastases to Bone
Pilot Randomized Study for Treatment Volume De-Escalation for Spinal Metastases With Stereotactic Body Radiation Therapy
A single centre, non-profit, randomised, unblinded pilot study on volume definition for spinal stereotactic body radiation therapy treatment. Randomization will be 1:1 between two types of SBRT treatment for spinal metastases.
- Trial name
- REVOL-SPINE (NCT07538024)
- Testing
- Stereotactic Body Radiation Therapy (SBRT) in control arm, Stereotactic Body Radiation Therapy (SBRT) in experimental arm
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Spinal Metastases
Randomized Trial on Same-day SBRT and Surgical Stabilization for Symptomatic Spinal Metastases
The BLEND RCT aims to evaluate the (cost-)effectiveness of same-day SBRT and surgical stabilization with or without decompression for the treatment of symptomatic, unstable spinal metastases on physical functioning four weeks…
- Trial name
- BLEND (NCT05575323)
- Testing
- Same-day SBRT and spinal surgery, Standard of care
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Spinal Neoplasms
Standard Dose Versus High Dose Stereotactic Spine Radiosurgery for Metastatic Spinal Neoplasms
The goal of this clinical trial is to learn if a higher dose of Stereotactic Spine Radiosurgery (SSRS), an advanced radiation technique, is better for treating cancer that has spread to the spine (spinal metastases).
- Trial name
- NCT07039968
- Testing
- Spine Stereotactic Radiosurgery (SSRS)
- Where
- 2 sites in Taiwan
- Volunteers
- 196 people
- Sponsor
- National Taiwan University Hospital
Metastatic Disease, Spinal Cord Injury
Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
The purpose of this study is to determine if the use of the Prevena™ System decreases the rate of subcutaneous seroma, superficial wound dehiscence and infection.
- Conditions
- Metastatic Disease, Spinal Cord Injury, Spinal Degeneration, Spinal Deformity
- Trial name
- NCT03632005
- Testing
- Vacuum Assisted Closure, Sterile dressing
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- John Street
Spinal Metastases, Solid Tumor Cancer
Preoperative Stereotactic Radiotherapy for Treatment of Spinal Metastases
The goal of this interventional clinical trial is to evaluate the efficacy and safety of preoperative hypofractionated Stereotactic Body Radiotherapy (SBRT) in the treatment of patients undergoing surgery for spinal metastases.
- Trial name
- PRESTRASM (NCT07135817)
- Testing
- Preoperative Stereotactic Body Radiotherapy (SBRT), Spinal Surgery for Decompression and/or Stabilization
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Medical Center Goettingen
Spinal Cord Compression Due to Metastasis to Spine
High-precision Radiotherapy of Motor Deficits Due to Metastatic Spinal Cord Compression
The major goal of this clinical study is to investigate to which extent high-precision radiotherapy (RT) with modern techniques can prevent progression or recurrence of motor deficits (weakness) of the legs following RT.
- Trial name
- PRE-MODE (NCT03070431)
- Testing
- High-precision RT 5x5 Gy in 1 week
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Schleswig-Holstein
Vertebral Metastasis
Conformal High Dose Intensity Modulated Radiation Therapy for Disease to Thoracic and Lumbar Spine
The purpose of this study is to determine if Conformal High Dose Intensity Modulated Radiation Therapy is an appropriate option for treating cancer that has spread to the spinal column.
- Trial name
- NCT01654068
- Testing
- Conformal High Dose Intensity Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ronald McGarry