Clinical trials: Spine Osteoarthritis
Arthritis, Psoriatic
A Study of Golimumab in Participants With Active Psoriatic Arthritis
The purpose of this study is to evaluate the efficacy of intravenously (administration of a fluid into the vein) administered golimumab 2 milligram per kilogram (mg/kg) in participants with active psoriatic arthritis (a chronic…
- Trial name
- NCT02181673
- Testing
- Golimumab
- Where
- 88 sites in United States, Australia and 10 more
- Volunteers
- 480 people
- Sponsor
- Janssen Research & Development, LLC
Delirium, Lumbar Radiculopathy
Shaping Anesthetic Techniques to Reduce Post-operative Delirium
The purpose of this study is to determine if light sedation with spinal anesthesia reduces the incidence of delirium compared to receiving general anesthesia during spinal surgery in older adults.
- Conditions
- Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
- Trial name
- SHARP (NCT03133845)
- Testing
- Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Johns Hopkins University
Ankylosing Spondylitis
Sequential Application of Yisaipu® and DMARDs in Treating Mild-to-Moderate AS
The drug regimes in treating ankylosing spondylitis(AS) have limitations. The tumor necrosis factor inhibitors(TNFi) was effective but expensive. Disease modifying anti-rheumatic drugs (DMARDs) were cheap but insufficient.
- Trial name
- NCT03411798
- Testing
- Yisaipu®
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Proprio Spine Measurement Tool
This study will prospectively collect data to evaluate the effectiveness of a novel intraoperative spinal measurement system to assist the surgeon with intraoperatively achieving pre-planned alignment-related parameters to the…
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis
- Trial name
- NCT07023393
- Testing
- Intraoperative spinal measurement system
- Where
- United States
- Sponsor
- Duke University
Axial Spondyloarthritis
A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(Alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis
The purpose of this study is to assess the efficacy of ustekinumab, in adult anti-TNF(alpha) refractory participants with active radiographic axial spondyloarthritis (AxSpA), as measured by the reduction in signs and symptoms of…
- Trial name
- NCT02438787
- Testing
- Ustekinumab 45 mg, Ustekinumab 90 mg, Golimumab 50 mg
- Where
- 148 sites in United States, Argentina and 17 more
- Volunteers
- 315 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis, Ankylosing Spondylitis
15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis
To evaluate serum and synovial fluid 15-PGDH levels in patients with osteoarthritis and ankylosing spondylitis and determine their associations with clinical and musculoskeletal ultrasound features.
- Trial name
- HPGD-OA-AS-US (NCT07751263)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assiut University
Psoriasis, Arthritis, Psoriatic
MYL-1401A Efficacy and Safety Comparability Study to Humira®
To assess the equivalence of MYL-1401A to Humira® with regards to efficacy in subjects with moderate-to-severe chronic plaque psoriasis
- Trial name
- NCT02714322
- Testing
- MYL-1401A (Adalimumab), Humira® (Adalimumab)
- Where
- 33 sites in Bulgaria, Estonia and 4 more
- Volunteers
- 294 people
- Sponsor
- Mylan Inc.
Rheumatoid Arthritis, Ankylosing Spondylitis
Employment and Arthritis: Making it Work
The investigators plan to conduct a randomized controlled trial to evaluate the effectiveness and the cost effectiveness of an on-line eLearning program (entitled Employment and Arthritis: Making it Work) designed to help people…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Lupus Erythematosus, Systemic, Psoriatic Arthritis
- Trial name
- MIW (NCT01852851)
- Testing
- Employment and Arthritis: Making it Work
- Where
- Canada
- Volunteers
- 528 people
- Sponsor
- University of British Columbia
Chronic Low-back Pain, Hip Impairments
Manual Therapy and Strengthening for the Hip in Older Adults With Chronic Low Back Pain
Older adults with chronic low back pain (LBP) are at a greater risk for disability, loss of independence, and lower quality of life.
- Conditions
- Chronic Low-back Pain, Hip Impairments, Hip-spine Syndrome, Osteoarthritis
- Trial name
- MASH (NCT04009837)
- Testing
- Hip-focused rehabilitation intervention, Spine-focused rehabilitation intervention
- Where
- 3 sites in United States
- Volunteers
- 184 people
- Sponsor
- University of Delaware
Axial Spondyloarthritis
Exploring the Feasibility and Acceptability of Virtual Reality Exercise for Pain Management, Fear of Movement, Mobility, and Proprioception Deficit in Axial Spondyloarthritis Patients During Flares: Twics Design
Axial spondyloarthritis (axSpA) is an autoimmune disease that causes inflammatory arthritis of the spine, causing pain, stiffness, and mobility limitations.
- Trial name
- NCT06967077
- Testing
- Virtual reality head set.
- Volunteers
- 40 people
- Sponsor
- University of Bath
Spondyloarthritis, Rhumatoid Arthisis
Papillomavirus Load in Rheumatic Inflammatory Diseases
Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common chronic inflammatory rheumatism, with a prevalence in the French population of 0.3% and 0.4%, according to the criteria European League Against…
- Trial name
- PAPLOR (NCT03713736)
- Testing
- Cervical smear, Pregnancy test, Sexual activity questionnary
- Where
- 3 sites in France
- Volunteers
- 385 people
- Sponsor
- Hospices Civils de Lyon
Psoriatic Arthritis, Axial Spondyloarthritis
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
To demonstrate that bimekizumab administered intravenously is noninferior to subcutaneous administration.
- Trial name
- NCT07290036
- Testing
- Bimekizumab regimen 1 iv, Bimekizumab regimen 2 iv, Bimekizumab regimen 3 sc
- Where
- 63 sites in United States, Bulgaria and 4 more
- Volunteers
- 392 people
- Sponsor
- UCB Biopharma SRL
Ankylosing Spondylitis, Axial Spondyloarthritis
A Clinimetric Test of Spinal Sensors in Measuring Spinal Mobility in Axial Spondyloarthritis
This is a clinimetric study to validate the use of IMU spinal sensors to measure the range of spinal movement in a group of patients with axial spondyloarthritis.
- Trial name
- NCT03159767
- Testing
- ViMove Spinal Sensor
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Dr Philip Gardiner
Psoriatic Arthritis
National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study
The purpose of this study is to determine whether DC-STAMP, a protein on the surface of osteoclast precursors (OCPs), can be used as a biologic marker in Psoriatic Arthritis (PsA).
- Trial name
- NCT01123265
- Testing
- Methotrexate, Anti-TNF
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Rochester
Rheumatoid Arthritis, Psoriatic Arthritis
Investigating the Utilisation and Effectiveness of Originator and Biosimilar Anti-TNF Agents
An observational study investigating the utilisation and effectiveness of originator and biosimilar anti-TNF agents in patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT03470688
- Testing
- Originator, Biosimilar
- Where
- 22 sites in Australia
- Volunteers
- 5,000 people
- Sponsor
- Opal Rheumatology Ltd.
Psoriatic Arthritis
TIght COntrol of Psoriatic Arthritis
The purpose of this study is to investigate whether tight control of patients with newly diagnosed psoriatic arthritis (consisting of regular 4 weekly objective assessment of disease activity and protocol-led intensive treatment)…
- Trial name
- TICOPA (NCT01106079)
- Testing
- Intensive management or Tight control, Standard management - Control group
- Where
- 3 sites in United Kingdom
- Volunteers
- 206 people
- Sponsor
- Julia Brown
In Seronegative Spondyloarthropathy
Investigating Atherosclerosis In Seronegative Spondyloarthropathy
The association between inflammation and atherosclerosis is widely known. An increase in morbidity and mortality due to cardiovascular (CV) disease in inflammatory rheumatic diseases has been proved [1-4].
- Trial name
- NCT04891783
- Testing
- ultrasonography
- Volunteers
- 120 people
- Sponsor
- Sohag University
Active Ankylosing Spondylitis or Non-Radiographic Axial Spondyloarthritis
Efficacy and Safety Study of SUNPG1622
This is a randomized, double-Blind, placebo-controlled Phase 2a study to evaluate the efficacy and safety of SUNPG1622.
- Trial name
- NCT02980705
- Testing
- SUNPG1622 I dose
- Where
- 4 sites in United States, Hungary and 2 more
- Volunteers
- 180 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Inflammatory Arthritis, Cardiovascular Risk Factor
Pharmacist CVD Intervention for Patients With Inflammatory Arthritis
Cardiovascular disease (CVD) (disease of the heart and blood vessels) is one of the leading causes of death and disability in Canada today. The majority of CVD cases are caused by factors that can be controlled.
- Conditions
- Inflammatory Arthritis, Cardiovascular Risk Factor, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- RxIALTA (NCT03152396)
- Testing
- CV risk assessment and modification of global risk
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Epidemiology Coordinating and Research Centre, Canada
Psoriatic Arthritis
Safety, Efficacy and Pharmacokinetics of an Antibody for Psoriatic Arthritis
The purpose of this study is to determine whether a humanized monoclonal antibody (efalizumab) is safe and effective in the treatment of psoriatic arthritis (PsA)
- Trial name
- NCT00051662
- Testing
- efalizumab
- Volunteers
- 45 people
- Sponsor
- XOMA (US) LLC
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