Clinical trials: Spine Osteoarthritis
Ankylosing Spondylitis
Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)
This study is a population-based cohort of patients with ankylosing spondylitis (AS) from general medical practices in the UK, France, and Germany with a nested case control component to assess associations between drug exposures…
- Trial name
- NCT01077843
- Testing
- Etoricoxib, Other Cox-2 inhibitors, Other Non-selective NSAIDs
- Volunteers
- 27,381 people
- Sponsor
- Organon and Co
Ankylosing Spondylitis
Neuropathic Spinal Pain in Ankylosing Spondylitis
The aim of this study is to investigate prevalence of neuropathic spinal pain in AS patients and it's impact on sleep quality. Moreover effects of neuropathic pain on quality of life and fatigue will be assessed.
- Trial name
- NCT04809168
- Testing
- Questionnaires and inventories
- Where
- Turkey (Türkiye)
- Volunteers
- 292 people
- Sponsor
- Bozyaka Training and Research Hospital
Spondyloarthritis
Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis
Investigation of wholebody MRI and circulating biomarkers of inflammation, cartilage and bone metabolism in patients with spondyloarthritis treated with adalimumab.
- Trial name
- ASIM (NCT01029847)
- Testing
- Adalimumab
- Where
- 8 sites in Denmark
- Volunteers
- 49 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spondylitis, Ankylosing
Prediction of Treatment Response at 6 Months by Combinatorial Analysis of Serum Biomarkers in Biotherapy Naive SpA
The main objective of this trial is to search for biomarkers associated with the success of adalimumab treatment in order to generate an algorithm to predict the response to this treatment at 6 months in spondyloarthritis and to…
- Trial name
- PRESHUM (NCT03561649)
- Testing
- Adalimumab
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Spondyloarthrosis
Study To Evaluate The Efficacy And Long-Term Adherence Of Spondyloarthropathies(SpA) Patients On Enbrel
This study is to evaluate local data in Iraqi patients with Spondyloarthropathies on Enbrel treatment with regards to efficacy and adherence using data from the Baghdad Teaching Hospital (Rheumatology Center)
- Trial name
- NCT04507776
- Testing
- Etanercept
- Where
- Iraq
- Volunteers
- 763 people
- Sponsor
- Pfizer
Psoriasis, Arthritis, Psoriatic
Anti-Carbamylated Protein Antibodies in Psoriatic Arthritis
Anti-carbamylated protein (anti-CarP) antibodies are present in approximately one-fourth of the patients who are seronegative for both rheumatoid factor and anti-citrullinated protein antibody and who may therefore have psoriatic…
- Trial name
- CARPAPA (NCT04173039)
- Testing
- Serum anti-CarP antibodies detection
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Association pour la Recherche Clinique et Immunologique
Ankylosing Spondylitis
Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain
The purpose of this study was to evaluate efficacy and safety of etanercept 100 mg (50 mg twice a week) compared with 50 mg once a week in adult subjects with ankylosing spondylitis (AS) and previous failure to usual practice…
- Trial name
- Loadet (NCT00873730)
- Testing
- etanercept
- Volunteers
- 108 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Axial Spondyloarthritis
Explore the Associations of Behavioral Factors With Treatment Adherence in Axial Spondyloarthritis Patients Treated With Biotherapy.
The management of chronic inflammatory rheumatism, including spondyloarthritis (SpA), has been revolutionized in recent decades with the arrival of biological therapy.
- Trial name
- MAINTAIN II (NCT04925037)
- Testing
- self-questionnaire to patients undergoing SpAax follow-up
- Where
- 5 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Psoriatic Arthritis
Imaging Treat-to-target Strategy vs Conventional Treat-to-target Strategy in Psoriatic Arthritis
The main objective is to assess if a treat-to-target strategy implementing structured imaging assessments leads to better patient outcome in terms of sustained remission compared to a conventional treat-to-target strategy in…
- Trial name
- NOR-SPRINT (NCT05291819)
- Testing
- Imaging informed treat-to-target, Conventional treat-to-target
- Where
- 12 sites in Norway
- Volunteers
- 202 people
- Sponsor
- Diakonhjemmet Hospital
Arthritis, Psoriatic
Guselkumab in Active Psoriatic Arthritis Participants With Inadequate Response/Intolerance to One Prior Anti-TNF Alpha Agent
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) and/or intolerance to a prior anti-tumor necrosis factor (TNF) by…
- Trial name
- SOLSTICE (NCT04936308)
- Testing
- Guselkumab
- Where
- 169 sites in United States, Argentina and 12 more
- Volunteers
- 453 people
- Sponsor
- Janssen Research & Development, LLC
Rheumatoid Arthritis, Systemic Lupus Erythematosus (SLE)
Mesenchymal Stem Cells Infusion in Patients With Autoimmune Diseases
The goal of this study is to learn if mesenchymal stem cell therapy (treatment group) can effectively treat autoimmune diseases, when compared to normal saline (given to placebo group).
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus (SLE), Systemic Sclerosis, Ankylosing Spondylitis (AS)
- Trial name
- MSCs in AD (NCT06888973)
- Testing
- Mesenchymal Stem Cells
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people
- Sponsor
- National Institute of Blood and Marrow Transplant (NIBMT), Pakistan
Ankylosing Spondylitis
Study Evaluating Predictors of Response in Patients With Ankylosing Spondylitis
The objective of this observational study is to determine the incidence of response in patients with predictive factors of major clinical response in active ankylosing spondylitis (AS) in patients who start anti-tumor necrosis…
- Trial name
- PRETEA (NCT00900796)
- Testing
- Treatment switching
- Where
- Spain
- Volunteers
- 132 people
- Sponsor
- Pfizer
Ankylosing Spondylitis
D2E7-Early AS
Reduction of signs and symptoms in patients with moderate to severely early axial spondyloarthritis (without radiological sacroiliitis) who have had an inadequate response to or do not tolerate NSAID therapy.
- Trial name
- NCT00235105
- Testing
- Adalimumab 40 mg sc every other week
- Where
- 2 sites in Germany
- Volunteers
- 46 people
- Sponsor
- Charite University, Berlin, Germany
Psoriatic Arthropathy Hand, Psoriatic Arthritis
The Effect of Psoriatic Arthritis on the Functions of the Hand
This study was planned to evaluate the effect of psoriatic arthritis on the strength, proprioception, skill, coordination, and functional condition of the hand and to determine the correlate disease activity with these parameters.
- Trial name
- NCT04540809
- Testing
- Assessment of strength, proprioception, skill and coordination of the hand
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Inonu University
Rheumatoid Arthritis, Psoriatic Arthritis
A Post-marketing Study to Assess the Safety of Abatacept in Sweden Using the Swedish Rheumatology Quality Register (SRQ) Register
The purpose of this study is to collect real-world data in order to estimate the frequency of overall malignancies, melanoma, basal cell carcinoma, and squamous cell carcinoma in participants with rheumatoid arthritis (RA) or…
- Trial name
- NCT05413044
- Where
- United States
- Volunteers
- 140,706 people
- Sponsor
- Bristol-Myers Squibb
Psoriasis, Psoriatic Arthritis
Efficacy and Safety Study of Two Doses of Apremilast (CC-10004) In Japanese Patients With Moderate-To-Severe Plaque-Type Psoriasis
This study will test the clinical effectiveness and safety of two orally administered doses of apremilast compared to placebo in Japanese patients with moderate-to-severe plaque-type psoriasis.
- Conditions
- Psoriasis, Psoriatic Arthritis, Psoriasis Arthropatica
- Trial name
- NCT01988103
- Testing
- Apremilast
- Where
- 56 sites in Japan
- Volunteers
- 254 people
- Sponsor
- Amgen
Ankylosing Spondyloarthritis
Study of Efficacy and Safety of Secukinumab in Patients With Ankylosing Spondylitis
The purpose of this trial is to demonstrate the clinical efficacy at week 16; and to demonstrate safety and tolerability of secukinumab compared to placebo in patients with ankylosing spondylitis at week 16 and long term safety…
- Trial name
- NCT02896127
- Testing
- Secukinumab
- Where
- 44 sites in China, Czechia and 2 more
- Volunteers
- 458 people
- Sponsor
- Novartis Pharmaceuticals
Ankylosing Spondylitis (AS)
Deep Breathing Combined With Core Stability Exercises in the Treatment of Patients With Ankylosing Spondylitis
Exercise may be considered the gold standard for the management of mechanical and functional symptoms associated with patients having AS and they are considered as a safe and effective treatment for improving strength, spinal…
- Trial name
- RCT (NCT07262294)
- Testing
- Exercises
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Beni-Suef University
Lumbar Spondylolisthesis, Arthrosis; Spine
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
To study the clinical efficacy of carosodiumsulfonate and desmopressin in improving the clarity of vision under endoscope, perioperative bleeding volume and anti-inflammatory effect in endoscopic lumbar fusion
- Trial name
- NCT06255366
- Testing
- Caroxime sodium sulfonate, Desmopressin, 0.9% Sodium Chloride Injection
- Volunteers
- 126 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Arthritis, Psoriatic
Certolizumab Pegol in Subjects With Adult Onset Active and Progressive Psoriatic Arthritis
Phase 3, multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of Certolizumab Pegol (CZP) in subjects with adult onset active and progressive Psoriatic Arthritis…
- Trial name
- NCT01087788
- Testing
- CZP 200 mg Q2W, CZP 400 mg Q4W
- Where
- 92 sites in United States, Argentina and 13 more
- Volunteers
- 409 people
- Sponsor
- UCB BIOSCIENCES GmbH
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