Clinical trials: Spine Surgeries
Spine Surgery
Motor Evoked Potentials and SedLine
To determine if using usual clinical practice plus a depth of anesthesia monitor, SedLine, to guide anesthetic administration improves the quality and ease of MEP monitoring in patients undergoing corrective spinal procedures.
- Trial name
- NCT00805844
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Osteoporosis, Post-menopausal
Romosozumab Effects on Bone Density, Muscle Mass, and Spine Surgery Outcomes
The goal of this clinical trial is to learn if romosozumab (Evenity) can improve bone and muscle health in postmenopausal women with osteoporosis who are undergoing lumbar spine surgery.
- Trial name
- NCT06973109
- Testing
- Romosozumab, Alendronate (Fosamax)
- Where
- United States
- Sponsor
- University of Pittsburgh
Anterior Cervical Spine Surgery
ACSS Approach on Dysphagia
Anterior cervical spine surgery (ACSS) is a procedure for the treatment of several neck problems. Even though the procedure is overall safe and effective, there are possible complications after surgery, which include problems…
- Trial name
- NCT07533864
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Pain After Surgery
RISS Versus Lower Thoracic ESP Block for Analgesia After Laparoscopic Abdominal Surgery: A Randomized Trial
The goal of this clinical trial is to investigate the analgesic efficacy of ultrasound-guided Romboid Intercostal and Subserratus (RISS) block versus lower thoracic Erector Spinae Plane (ESP) block after laparoscopic abdominal…
- Trial name
- NCT07593300
- Testing
- Group A (n=35): Ultrasound-guided RISS block (RISS):, Group B (n=35): Ultrasound-guided lower thoracic ESP block
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Degenerative Lumbar Spine Diseases, Lumbar Spinal Instability
Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease
This study examines how well computed tomography (CT) imaging performed during spine surgery - known as intraoperative CT - can detect instability in the lower (lumbar) part of the spine.
- Conditions
- Degenerative Lumbar Spine Diseases, Lumbar Spinal Instability, Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- INSIGHT-CT (NCT07644507)
- Testing
- Intraoperative Computed Tomography (O-arm)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Spine Surgery
"Efficacy of Hybrid Systems ("Topping Off") Versus Rigid Spinal Fusion in Lumbar Fusion Surgery: A Dual-center, Prospective, Randomized Pilot Study ("CD Horizon BalanC")"
Effectiveness of hybrid systems ("topping off") compared to rigid spondylodesis in fusion surgery of the lumbar spine: A prospective, randomized, bicentric pilot study ("CD HORIZON BalanC™)
- Trial name
- BalanC (NCT02551302)
- Testing
- Solera™ Medtronic, CD HORIZON BalanC™ Medtronic
- Volunteers
- 60 people
- Sponsor
- University of Cologne
Spine Disease, Neurological Disorder
EMG and SSEP Device (EPAD® 2.0) for Intraoperative Monitoring of Patient Undergoing Spinal Nerve Spine Surgery
In patients undergoing spine surgery, spinal nerve roots and spinal cord are vulnerable to surgical insults especially for instrumentation and may lead to long term sequelae.
- Trial name
- NCT03848377
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Bypass Graft Surgery, Spine Surgery
Does Pre-operative Carbohydrate Loading Reduce Insulin Resistance and Improve Outcomes in Elective Surgical Patients?
The recent development of an oral carbohydrate drink for consumption prior to elective surgical procedures has been shown to improve insulin sensitivity.
- Trial name
- Preop (NCT00618592)
- Testing
- PreOp carbohydrate drink
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Lumbar; Injury
A Single Session Pain Psychology Class for Spine Surgery Patients
This project tests the feasibility a single session pain psychology class (TREK for Surgical Success) for patients undergoing spine surgery and compares outcomes in those who engage in the class to a historical group of similar…
- Trial name
- NCT03985436
- Testing
- Trek for Surgical Success
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sara Davin, PsyD, MPH
Scoliosis, Kyphosis
Pharmacogenomics of Methadone in Spine Fusion Surgery
The overall objective is to develop a patient oriented research program to efficiently evaluate the effects of pharmacogenetic variants on the dose-response relationships and safety of opioids and non-opioid analgesics.
- Trial name
- NCT01677650
- Testing
- Methadone
- Where
- United States
- Sponsor
- Northwestern University
Hypoxia, Myocardial Injury
Myocardial Injury and Intraoperative Tissue Oximetry in Patients Undergoing Spine Surgery
Myocardial injury after non-cardiac surgery (MINS) is common in patients undergoing major surgery. Many of the events are undetected and associated with a high 30-day mortality risk.
- Conditions
- Hypoxia, Myocardial Injury, Surgery--Complications
- Trial name
- MONITOR (NCT03518372)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Spine Degeneration, Spine Disorder
Rate of Bone Union After Surgery With Stand-alone Fibergraft
Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking.
- Conditions
- Spine Degeneration, Spine Disorder, Spine Pain, Spine Fusion
- Trial name
- Fibergraft (NCT07199075)
- Testing
- Questionnaires, Computer Tomography
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- AO Innovation Translation Center
Lower Back Pain
Safety and Performance of the Elaspine System in the Treatment of the Lumbar Spine
The safety and performance of the Elaspine™ Implant System in the treatment of lower back pain will be evaluated with a prospective and nonrandomized, multicenter post-marketing clinical study (PMCS).
- Trial name
- NCT01323543
- Testing
- Elaspine™
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 40 people
- Sponsor
- Spinelab AG
Spine Metastases
Minimally Invasive Surgery (MIS) for Spine Metastases
The purpose of this study is to collect information on the effect of minimally invasive spine tumor decompression on treated patients.
- Trial name
- NCT02367378
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypopharyngeal Pressure Changes Between Before and After Swallowing Rehabiliation
Enhancing Early Swallowing Recovery in Older Dysphagic Patients Afetr Anterior Cervical Spine Surgery
The early swallowing rehabilitation program in older patients receiving elective surgery is regarded to enhance the recovery pf swallowing ability.
- Trial name
- NCT05494515
- Testing
- the early swallowing rehabilitation program
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Back Pain With Radiation, Pain, Postoperative
Spinal Cord Burst Stimulation for Chronic Radicular Pain Following Lumbar Spine Surgery
Spinal cord stimulation (SCS) is a widely applied therapy to treat chronic neuropathic pain, and one of the most common indications is persisting radicular neuropathic pain following lumbar spine surgery.
- Trial name
- NCT03546738
- Testing
- Burst Spinal Cord Stimulation, SCS implant
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- St. Olavs Hospital
Pain
The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery
The analgesic effect of dexamethasone is not well described, but studies have shown that dexamethasone can be a safe part of a multimodal analgesic strategy after surgery.
- Trial name
- NCT01953978
- Testing
- Dexamethasone, Morphine, Zofran
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lumbar Disc Disease, Spinal Fusion
Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery
The purpose of this study is to determine if treatment with low-dose oral propranolol in the days before and after surgery decrease postoperative pain and improve pain scores.
- Conditions
- Lumbar Disc Disease, Spinal Fusion, Degenerative Disc Disease
- Trial name
- NCT04421209
- Testing
- Propranolol Hcl 40mg Tab
- Where
- United States
- Sponsor
- Duke University
Spine Surgery, Postoperative Pain Management
Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes
The goal of this clinical trial is to learn if using calcium sulfate beads that contain vancomycin (an antibiotic) and pain-relieving medicines during spine surgery can improve recovery compared to standard care with intravenous…
- Trial name
- NCT07201987
- Testing
- Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads)
- Volunteers
- 100 people
- Sponsor
- Ganesh M. Shankar
Spine Deformity
Comparative Study for Incidence of Proximal Junctional Kyphosis Between Parathyroid Hormone and Denosumab Following Adult Spinal Deformity Surgery : A Prospective, Randomized Controlled Trial
Medical therapy that can lower PJK rates are also being sought. Teriparatide (TP), a recombinant human parathyroid hormone (PTH 1-34), is a bone forming agent mainly used to treat osteoporotic patients with high risk of…
- Trial name
- NCT04241211
- Testing
- Forsteo, Denosumab Prefilled Syringe [Prolia]
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Bundang Hospital