Clinical trials: Spine Surgeries
Spine Surgery, Surgery
Use of Surgify Safety Burr in Hard Tissue Cutting, Head and Spine Area
Purpose of the study: To evaluate whether the SSB is safe, useful, beneficial and effective in drilling, cutting and removal of bone tissue in neurosurgical and spine procedures.
- Trial name
- NCT05269836
- Testing
- Surgify Safety Burr
- Where
- Finland
- Volunteers
- 22 people
- Sponsor
- Surgify Medical Oy
Acute Pain, Chronic Pain
ERECTOR SPINE PLANE BLOCK VERSUS LOCAL INFILTRATION ANAESTHESIA FOR TRANSFORAMINAL PERCUTANEOUS ENDOSCOPIC DISCECTOMY
The main aim of our study was to test the hypothesis that Erector spine plane block (ESP) with sedation will provide the similar employment of fentanyl and propofol during surgery as an infiltrative local anaesthesia with…
- Conditions
- Acute Pain, Chronic Pain, Postoperative Pain, Anesthesia
- Trial name
- NCT05483647
- Testing
- Local infiltrative anaesthesia, Erector spine plane block
- Where
- Ukraine
- Volunteers
- 52 people
- Sponsor
- Lviv National Medical University
Urinary Retention Postoperative
Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
The purpose of this research is to see if the use of tamsulosin can decrease both the incidence and duration of urinary retention, as well as hospital length of stay following spine surgery.
- Trial name
- NCT07174349
- Testing
- Uroselective alpha-1-adrenergic receptor antagonist
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Chlorzoxazone, Postoperative Pain
The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery
Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.
- Trial name
- NCT01933542
- Testing
- Chlorzoxazone, Morphine, Zofran
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Visual Evoked Potentials
Cyclopol on Electrophysiological Monitoring During Spine Surgery: a Randomized Controlled, Noninferiority Study
Postoperative visual function injury occurs after spinal cord, neurosurgery, ophthalmology and other operations, which directly affects the postoperative quality of life of patients.
- Trial name
- NCT05617690
- Testing
- Cyclopol, Propofol
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Beijing Tiantan Hospital
Degenerative Disc Disease, Degenerative Spondylolisthesis
Lumbar Interbody Implant Study
The objective of this study is to evaluate the safety and performance of NuVasive interbody implants when used during thoracic and/or lumbar spine surgery as measured by reported complications, radiographic outcomes, and…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis
- Trial name
- NCT04418830
- Where
- 16 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- NuVasive
Opioid Use, Pain, Acute
Pre-post Erector Spine Plane Block-spinal Surgery
Spinal surgery patients generally have chronic pain in the preoperative period and are exposed to widespread and severe acute pain postoperatively.
- Trial name
- pre-post-esp (NCT06215053)
- Testing
- erector spine plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Aydin Adnan Menderes University
Degenerative Disk Disease, Spondylolisthesis
Prospective Study of Minimally Invasive Spine Surgery
The population of the US is aging. They remain more active and place greater demands on their musculoskeletal system. A key problem is that pain and disability of age related spinal disorders will increase.
- Conditions
- Degenerative Disk Disease, Spondylolisthesis, Spinal Stenosis, Degenerative Scoliosis
- Trial name
- NCT01045473
- Volunteers
- 450 people
- Sponsor
- Society for Minimally Invasive Spine Surgery
Lumbar Spine Disc Herniation
Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery
The purpose of this study is to Compare three methods of intrathecal bupivacaine; bupivacaine-fentanyl; bupivacaine-fentanyl-magnesium sulfate on sensory-motor blocks and postoperative pain in patients undergoing lumbar disk…
- Trial name
- NCT01843296
- Testing
- Magnesium Sulfate, Spinal Anesthesia, Bupivacaine
- Where
- Iran
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Opioid Withdrawal
Lofexidine for Adults Undergoing Lumbar Spine Surgery
The primary objective is to investigate the effects of lofexidine in adults undergoing opioid tapering prior to elective lumbar spine surgery.
- Trial name
- NCT04126083
- Testing
- Lofexidine Oral Tablet
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Spinal Diseases
The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery.
The purpose of this study is to evaluate the effectiveness of perioperative Lidocaine intravenous infusion in reducing postoperative pain for spine surgery patients.
- Trial name
- NCT02762656
- Testing
- Lidocaine
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Peripheral Nerve Disease, Muscular Injury
Innervation Characteristics and Determination of Nerve Entry Points of the Musculus Semispinalis Capitis
The aim of this study is to determine the innervation characteristics and nerve entry points of the musculus semispinalis capitis.
- Trial name
- NCT06569563
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Medipol University
Lumbar Spine Fusion Surgery
Multimodal GA for Lumbar Spine Surgery
To evaluate the effects of multimodal general anesthesia on the recovery profile of elder patients undergoing lumbar spine fusion surgery.
- Trial name
- NCT05247177
- Testing
- dexmedetomidine, ketamine co-administration with sevoflurane for general anesthesia, Conventional general anesthesia by administration of sevoflurane alone
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS).
- Conditions
- Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- ECAP-MED Pilot (NCT07502612)
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brai²n
Spine Surgery
Radiological and Clinical Efficacy of a Hybrid Spinal Implant ("Topping Off"): a Mono-center, Prospective Clinical Trial
The study aim is to show the effectiveness of a hybrid system (DTO) regarding clinical outcome and radiological alteration in a single-center prospective setting.
- Trial name
- NCT03404232
- Testing
- Dynesys DTO device (Zimmer Spine, Inc.)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Aachen
Lumbar Spine Surgery Postoperative Ileus
Ileus After Lumbar Spine Surgery
Postoperative ileus (POI) after lumbar spine surgery is not uncommon. However, the incidence, severity and risk factors of ileus after spine surgery remain uncertain because there is not yet a prospective investigation using a…
- Trial name
- NCT04057599
- Where
- Taiwan
- Volunteers
- 156 people
- Sponsor
- National Taiwan University Hospital
Scoliosis
Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery
Tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) have been reported to reduce blood loss in the cardiac surgery literature but they have not been reported in use head-to-head in the orthopedic surgery literature.
- Trial name
- NCT00958581
- Testing
- Tranexamic Acid, Normal Saline, Epsilon aminocaproic acid
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- NYU Langone Health
Spine, Pain
Effect of Magnesium on Neuromonitoring
Intraoperative neurophysiologic monitoring (IONM) is commonly used during complex spinal surgery to monitor the integrity of neural structures and improve the perioperative safety profile.
- Conditions
- Spine, Pain, Spine Surgery, Spine Surgery With Neuromonitoring
- Trial name
- MgNm (NCT06975072)
- Testing
- Magnesium sulfate administration
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Lumbar Spinal Stenosis, Lumbar Spinal Instability
Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients
Patients presenting for lumbar spine surgery experience pain related to their spine condition. Following surgery, these patients also experience surgical pain resulting from disruption of skin, muscle tissue, vertebrae…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
- Trial name
- IPaRO (NCT03088306)
- Testing
- Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia]
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Johns Hopkins University
Thyroid, Surgery
A Deep Learning Method to Predict Difficult Laryngoscopy Using Cervical Spine X-ray Image
An unanticipated difficult laryngoscopy is associated with serious airway-related complications. The investigators developed a deep learning-based model that predicts a difficult laryngoscopy (Cormack-Lehane grade 3-4) from a…
- Conditions
- Thyroid, Surgery, Intubation; Difficult or Failed
- Trial name
- NCT05176184
- Testing
- A deep learning model for predicting a difficult laryngoscopy based on a cervical spine lateral X-ray image
- Where
- South Korea
- Volunteers
- 367 people
- Sponsor
- Seoul National University Hospital