Clinical trials: Spine Surgeries
Symptomatic Cervical Disc Disease
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease…
- Trial name
- SMART (NCT04012996)
- Testing
- prodisc C SK and/or Vivo, Mobi-C Cervical Disc
- Where
- 30 sites in United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Centinel Spine
Surgical Procedure, Unspecified
Evaluation of an 3D Imaging Intensifier Coupled to a Navigation Station in the Surgery of the Spine and Pelvis
The purpose of this study is to demonstrate an optimization of the establishment of orthopedic implants in surgery of the spine and pelvic ring by combining 3D fluoroscopy and navigation system versus conventional method…
- Trial name
- FLUORONAV (NCT01335841)
- Testing
- Navigation station coupled with a 3D fluoroscopy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- AdministrateurCIC
Spine Deformities, Idiopathic Scoliosis
Blood Propofol Concentrations in Children During Spinal Surgery
During major spinal surgery evoked potential monitoring is performed to detect spinal cord damage. Intra-venous anaesthesia is the preferred anaesthetic technique because volatile anaesthetic agents supress the evoked potentials.
- Conditions
- Spine Deformities, Idiopathic Scoliosis, Neuromuscular Dystrophy
- Trial name
- NCT01932424
- Testing
- Pelorus 1500, Propofol 2% (Diprivan 2%, Astra Zeneca UK)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Low Back Pain
Influence of Supervised Stabilization Exercises on Postural Control in Patients After Spine Surgery.
The aim of the study is to determine the impact of early rehabilitation in patients after lumbar spine surgery using microdiscectomy on balance, postural stability and foot pressure distribution.
- Trial name
- NCT05190003
- Testing
- Experimental Study
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Postoperative Pain
Effect of Lidocaine Versus Magnesium on Postoperative Pain in Spine Surgery
The goal in this work is to compare the effect of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status and quality of life in patients…
- Trial name
- NCT04776369
- Testing
- Lidocaine IV, Magnesium Sulfate Injection, IV saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Haitham Mohammad Ahmad Mohammad
Postoperative Pain, Pregabalin
Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects
The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.
- Conditions
- Postoperative Pain, Pregabalin, Spine Surgery, Adverse Reaction to Pregabalin
- Trial name
- NCT05478382
- Testing
- Pregabalin 25 MG
- Volunteers
- 132 people
- Sponsor
- Ajou University School of Medicine
Constipation
Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery
In the present study, the primary aim was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced opioid induced constipation in patients with or without chronic opioid treatment undergoing spine surgery.
- Trial name
- oksineukir (NCT02573922)
- Testing
- oxycodone-naloxone, Oxycodone
- Where
- Finland
- Volunteers
- 180 people
- Sponsor
- Kuopio University Hospital
Spine Disease, Regional Anaesthesia
Erector Spine Block for Back Surgery
In spine surgery postoperative pain can often be severe and difficult to treat.With the use of ultrasound, the performance of plane blocks and other techniques like root blocks, facet infiltration have become possible without the…
- Trial name
- NCT03214536
- Testing
- erector spinae block, Ropivacaine, Spine surgery
- Where
- 2 sites in Belgium
- Volunteers
- 15 people
- Sponsor
- University Hospital, Antwerp
Anterior Cervical Spine Surgery
ACSS Approach on Dysphagia
Anterior cervical spine surgery (ACSS) is a procedure for the treatment of several neck problems. Even though the procedure is overall safe and effective, there are possible complications after surgery, which include problems…
- Trial name
- NCT07533864
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Lumbar Spine Injury
The Use of Dantrolene to Improve Analgesia in Posterior Lumbar Surgery
The purpose of this study is to determine whether administration of a non-centrally acting muscle relaxants will improve the Overall Benefit of Analgesia Score (OBAS), and Richmond Agitation Sedation Scale (RASS) scores in…
- Trial name
- NCT03762109
- Testing
- Dantrolene
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cervical Spine Surgery
Laryngoscope Asssited Lightwand Intubation
To evaluate the success rate for intubation of laryngocope assisted lightwand intubation.
- Trial name
- NCT01950702
- Testing
- Laryngoscope assisted lightwand intubation, Lightwand intubation
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Seoul National University Hospital
Spine Fracture
Surgical Treatment of Fractures of the Dorso-lombar Spine
Trauma to the thoracolumbar spine is responsible for potentially serious lesions, most often involving the functional prognosis in the short, medium and long term, and rare The frequency of these traumas is explained by falls…
- Trial name
- NCT06374472
- Testing
- Osteosynthesis
- Where
- Tunisia
- Volunteers
- 80 people
- Sponsor
- Ibn Jazzar Hospital
Surgical Site Infections, Post Operative Complication
2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients
Surgical site infection (SSI) following spinal surgery is a frequent complication and results in higher morbidity, mortality and healthcare costs.
- Trial name
- DeSSI (NCT02490631)
- Testing
- 2% chlorhexidine gluconate cloths
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Vanderbilt University
Lumbar Degenerative Disease
CONDUIT™ Anterior Lumbar Interbody Fusion (ALIF) Cage System in Lumbar Degenerative Disease
This will be a prospective, multi-centre study at a National Tertiary Referral Centre for spinal trauma and spinal cord injuries, serving a catchment area of 5 million people.
- Trial name
- NCT06940453
- Testing
- CONDUIT
- Where
- Ireland
- Volunteers
- 35 people
- Sponsor
- University College Dublin
Spine Disease, Neurological Disorder
EMG and SSEP Device (EPAD® 2.0) for Intraoperative Monitoring of Patient Undergoing Spinal Nerve Spine Surgery
In patients undergoing spine surgery, spinal nerve roots and spinal cord are vulnerable to surgical insults especially for instrumentation and may lead to long term sequelae.
- Trial name
- NCT03848377
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Degenerative Spine Diseases
Vertebral Bone Marrow Clot for Spinal Surgery
Spinal fusion (SF) is a common orthopedic procedure to treat spinal diseases. Apart from fixation systems, the procedure requires bone grafting to further improve SF.
- Trial name
- NCT05947175
- Testing
- Vertebral bone marrow (vBMA) clot, Bone allograft chips
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Istituto Ortopedico Rizzoli
Single Level Lumbar Decompression and Fusion Spine Surgery
Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study
The purpose of this study is to determine if post-operative pain and rate of recovery are improved in patients undergoing spine surgery using MMA (multimodal analgesia) compared to usual analgsic care.
- Trial name
- NCT02202369
- Testing
- Multimodal Analgesia Treatment, Standard of Care Pain Management Protocol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Surgical Site Infection (SSI), Spine Diseases
Efficacy of Intrawound Vancomycin in Spine Surgery
"This multicenter, prospective, time-cluster randomized controlled trial with blinded endpoint assessment (PROBE design) evaluated the efficacy of intrawound vancomycin powder (2 g) in preventing surgical site infections (SSI)…
- Trial name
- NCT07866157
- Testing
- vancomycin, Standard surgical closure
- Where
- Egypt
- Volunteers
- 416 people
- Sponsor
- Ain Shams University
Subjects Treated With Karma Fixation System as Part of Their Spine Surgery
Karma Ambispective Study
The purpose of this observational, multi-center, ambispective study is collect real world patient outcomes that characterize the effectiveness of the Karma Fixation System in the lumbar spine.
- Trial name
- NCT07207187
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Spinal Elements
Spine Deformity
Novel Pedicle Screws Used for Corrective Surgery in Spinal Deformity
There are still a large number of severe spinal deformity cases which would keep progressing without treatment. These patients not only have severe appearance deformity, but also suffer from cardiopulmonary compression, reduced…
- Trial name
- NCT06144879
- Testing
- double rods without dual-headed screw, three rods with one dual-headed screw, four rods with two dual-headed screw
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School