Clinical trials: Spine Surgeries
Mesenchymal Tumor
High-Dose Proton/Photon RT + Surgery of Sarcomas of the Thoracic, Lumbar Spine/Sacrum
The purpose of this study is to test the effectiveness of high dose radiation administered by both proton and photon therapy. Radiation is an effective treatment for many types of tumors and it is thought that radiation alone…
- Trial name
- NCT00592345
- Testing
- Proton Beam Radiation, Photon Beam Radiation, Interoperative radiation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Scoliosis
Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery
Tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) have been reported to reduce blood loss in the cardiac surgery literature but they have not been reported in use head-to-head in the orthopedic surgery literature.
- Trial name
- NCT00958581
- Testing
- Tranexamic Acid, Normal Saline, Epsilon aminocaproic acid
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- NYU Langone Health
Lumbar Spine Stenosis, Lumbar Disc Herniation
Dynamic Compliance-Guided Ventilation in Lumbar Surgery
Postoperative pulmonary complications are a frequent cause of morbidity following lumbar stabilization surgery. Conventional ventilation strategies may not adequately reflect intraoperative changes in respiratory mechanics…
- Conditions
- Lumbar Spine Stenosis, Lumbar Disc Herniation, Ventilator-Induced Lung Injury, Postoperative Complications
- Trial name
- NCT07349719
- Testing
- Dynamic Compliance Guided Ventilation, Standard Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Stenosis Lumbar, Disc Herniation, Lumbar
More Realistic Spine Patients: Assessing the Effect of Dialogue Support Tool.
This multicenter randomized controlled trial will evaluate whether an additional preoperative study visit using the Dialogue Support (DS) tool improves patient information, expectations, and outcomes among adults scheduled for…
- Conditions
- Spinal Stenosis Lumbar, Disc Herniation, Lumbar, Degenrative Disc Disease
- Trial name
- MORESP (NCT07788872)
- Testing
- Dialogue Support Study Visit
- Where
- 2 sites in Norway
- Volunteers
- 440 people
- Sponsor
- University Hospital, Akershus
Radius; Deformity, Hip Osteoarthritis
Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology
Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications.
- Conditions
- Radius; Deformity, Hip Osteoarthritis, Hip Arthritis, Hip Arthropathy
- Trial name
- NCT06603831
- Testing
- patients treated using 3D technology and Patient-Specific Instrumentation, Patients treated with conventional surgery, without using 3D technology
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Corporacion Parc Tauli
Analgesia, Pain, Postoperative
Effects of Intraoperative Magnesium Sulfate on Perioperative Pain Relief After Spine Surgery
The treatment of postoperative pain is increasingly based on a multimodal approach and although opioids remain the drug of choice, they are often used in combination with other analgesics (paracetamol, cyclooxygenase inhibitors…
- Conditions
- Analgesia, Pain, Postoperative, Spine Disease
- Trial name
- NCT04161729
- Testing
- Magnesium Sulfate, Isotonic saline 0.9%
- Where
- Greece
- Volunteers
- 74 people
- Sponsor
- Aristotle University Of Thessaloniki
Post-Op Complication, Spine Surgery
Irrisept Solution for Instrumented Spine Surgery
Various spine surgeons perform wound irrigation using saline mixed with vancomycin, relying on mechanical debridement of non-viable tissue, physical disruption of biofilm, and bacteriostatic effect against gram positive flora.
- Conditions
- Post-Op Complication, Spine Surgery, Site Infection, Surgical Site Infection
- Trial name
- NCT06439953
- Testing
- Chlorhexidine gluconate solution, Vancomycin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rhode Island Hospital
Opioid Use, Pain, Acute
Pre-post Erector Spine Plane Block-spinal Surgery
Spinal surgery patients generally have chronic pain in the preoperative period and are exposed to widespread and severe acute pain postoperatively.
- Trial name
- pre-post-esp (NCT06215053)
- Testing
- erector spine plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Aydin Adnan Menderes University
Spinal Deformity
Supplemental Anterior Lumbar Interbody Fusion (ALIF) in Spinal Deformity
Within the last decade there has been an increase in the number of surgical procedures for deformities of the spine. This is caused by the increase in the elderly population, improved surgical techniques and an increased number…
- Trial name
- SALIF (NCT01601054)
- Testing
- Tantalum cage from Zimmer
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain Postoperative
Sngception and Pain in Spine Enhanced Recovery After Surgery (ERAS) Pathways
Enhanced recovery after surgery (ERAS) is a recognized, evidence-based and patient-centered clinical pathway that has an array of benefits.
- Trial name
- NCT05885802
- Testing
- No specific intervention other than routine anesthesia protocol
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Scoliosis
Evaluate Initial Safety of the HemiBridge™ System in Guided Spinal Growth Treatment of Progressive Idiopathic Scoliosis
The purpose of this clinical trial is to study a new method of treatment for patients who are diagnosed with idiopathic scoliosis and have abnormal and increasing curvature of the spine.
- Trial name
- NCT01465295
- Testing
- Mechanical hemiepiphysiodesis using the HemiBridge System
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- SpineForm LLC
Metastatic Spine Tumor
Metastatic Tumor Research and Outcomes Network
The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with…
- Trial name
- MTRON (NCT02830451)
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 2,417 people
- Sponsor
- AO Innovation Translation Center
Osteosynthesis, Mazor Robot
Study Comparing Arthrodesis Technique of Thoracic and/or Lumbar Spine by Posterior Approach Performed by Robot-assisted Surgery (Robot Mazor X Stealth ™) Versus Conventional Surgery
Osteosynthesis by pedicle screwing is the reference technique since the 1980s, due to the quality of the mechanical grip of the screw in the pedicle, despite difficulties of placing the implant in this narrow tunnel.
- Conditions
- Osteosynthesis, Mazor Robot, Spinal Surgery, Arthrosis; Spine
- Trial name
- ROBARTHRODESE (NCT05553028)
- Testing
- Computerised tomography
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Elsan
Surgical Blood Loss, Spinal Surgery
Efficacy of Suction Enabled Retraction Device
This is a prospective randomized controlled trial of the Suction-Integrated Surgical Tissue Elevator \& Retractor [SISTER] device to assess: Effects on operative time and efficiency of exposure in open lumbar spine cases.
- Trial name
- NCT03160170
- Testing
- SISTER device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Miami
Erector Spinae Plane Block, Neutrophil to Lymphocyte Ratio
The Relationship Between NLR and PONV and ESPB
This study aims to investigate whether preoperative NLR (Neutrophil-to-Lymphocyte Ratio) serves as a biomarker for PONV (Postoperative Nausea and Vomiting).
- Trial name
- NCT06127966
- Testing
- Erector Spinae Plane Block, 0.9% physiological saline (20ml) injection under ultrasound-guided Erector Spinae Plane Block (ESPB).
- Volunteers
- 220 people
- Sponsor
- Qianfoshan Hospital
Anemia, Venous Thrombosis
A Study to Confirm the Safety and Efficacy of Epoetin Alfa (PROCRIT) Administered Perioperatively vs. the Standard of Care in Blood Conservation in Patients Undergoing Major Elective Spinal Surgery (SPINE Study)
This study is designed to investigate the incidence of deep vein thrombosis in patients receiving a perisurgical regimen of epoetin alfa (PROCRIT®) as compared to patients receiving standard of care blood conservation management.
- Trial name
- NCT00211146
- Testing
- epoetin alfa
- Volunteers
- 680 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Spinal Surgery
The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.
Chloride-rich isotonic crystalloid solutions have been shown to exert electrolyte imbalance and metabolic acidosis in critically ill patients.
- Trial name
- NCT01855542
- Testing
- 0.9% normal saline, plasmalyte
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Patients Under Hip, Femur, Spine Operation
Effect of Dexmedetomidine on Postoperative Delirium Inflammasome Activation Inhibition
Delirium is an acute or subacute comorbid syndrome characterized by decreased awareness and cognitive dysfunction accompanied by attention deficit. It varies from 20% to 80%, depending on the report.
- Trial name
- NCT03588988
- Testing
- Dexmedetomidine IV infusion, Normal saline
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Propofol, Fentanyl
Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring
The objective of this study is to evaluate the effect of adding dexmedetomidine on evoked potentials in adult patients undergoing spinal surgery under intravenous anesthesia
- Conditions
- Propofol, Fentanyl, Dexmedetomidine, Sevoflurane
- Trial name
- NCT06210061
- Testing
- Propofol-Fentanyl, Propofol-Fentanyl-Dexmedetomidine, Propofol-Fentanyl-Sevoflurane
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
Major Spine Surgery Procedure
Masimo Radical-7 Monitor a Useful Adjuvant During Major Spine Surgery
This is a study designed to compare the agreement of hemoglobin (Hb) measurements, documented at specific time points (the time a blood sample was obtained by the standard clinical care after physician/nurse orders it and, during…
- Trial name
- NCT01221961
- Testing
- Masimo Radical-7
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Cedars-Sinai Medical Center