Clinical trials: Spine Surgeries
Bleeding
Reduction Bleeding in Laminectomy With Double Doses of Tranexamic Acid
Tranexamic acid has benn widely used to reduce perioperative bleeding in several operations such as cardiac surgery, liver transplant and joint arthroplasty with good results.
- Trial name
- NCT01643135
- Testing
- tranexamic acid, 0.9% NaCl
- Where
- Thailand
- Volunteers
- 78 people
- Sponsor
- Mahidol University
Pain, Postoperative, Opioid Use
Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.
The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump.
- Conditions
- Pain, Postoperative, Opioid Use, Major Surgery
- Trial name
- NCT06774274
- Testing
- Ketamine infusion, PCA Ketamine
- Where
- Colombia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Cervical Spine Surgery
Laryngoscope Asssited Lightwand Intubation
To evaluate the success rate for intubation of laryngocope assisted lightwand intubation.
- Trial name
- NCT01950702
- Testing
- Laryngoscope assisted lightwand intubation, Lightwand intubation
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Seoul National University Hospital
Scoliosis, Kyphosis
Postoperative and Chronic Pain Genetic Spine and Pectus Surgery Study
This will be an open label, prospective study to determine the association between specific genotypes, epigenetics and behavioral factors, with the phenotypes, defined by pain perception, postoperative pain, analgesic and side…
- Conditions
- Scoliosis, Kyphosis, Kyphoscoliosis, Pectus Excavatum
- Trial name
- NCT02998138
- Where
- 5 sites in United States
- Volunteers
- 880 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pharmacological Action
The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.
In this randomized double blind placebo controlled study of tranexamic acid during minor spinal surgery, mean postoperative blood loss in the patients who received TXA was statistically significantly lower compared to placebo.
- Trial name
- NCT03714360
- Testing
- Tranexamic Acid, Sodium Chloride 0,9%
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Mikkel Østerheden Andersen
Urinary Retention Postoperative
Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
The purpose of this research is to see if the use of tamsulosin can decrease both the incidence and duration of urinary retention, as well as hospital length of stay following spine surgery.
- Trial name
- NCT07174349
- Testing
- Uroselective alpha-1-adrenergic receptor antagonist
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Spine Surgery, Postoperative Delirium and Chills
Scheme of Limb Warming Blanket Combined With Dexmedetomidine
Objective: To observe the clinical effect of lower limb warming blanket combined with dexmedetomidine (DEX) in preventing postoperative delirium (POD) and chills in elderly patients undergoing spinal surgery.
- Trial name
- NCT05857410
- Testing
- Dexmetomidine, Lower limb heating blanket
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Jincheng General Hospital
Chronic Post Surgical Pain
Enhanced vs.Standard Pain Management of Patients at Risk for Chronic Post-surgical Pain
The goal of this pragmatic pilot clinical trial is to test the feasibility of the trial in terms of the number of patients recruited in a given period.
- Trial name
- ALDOpilot (NCT05787691)
- Testing
- Individualised pain management
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Scoliosis; Adolescence, Spine Fusion
Evaluation of Surgical Treatment of Idiopathic Scoliosis With Vertebral Body Tethering Versus Posterior Spinal Fusion.
The aim of this study is to evaluate the short, medium and long-term efficacy and safety of vertebral body tethering, based on the results obtained at 3-5 months of follow-up, exploring not only the ability to correct scoliosis…
- Trial name
- NCT07450326
- Testing
- gait analysis
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Istituto Ortopedico Rizzoli
Pain, Postoperative, Opioid Use
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
The purpose of this study, entitled "Delivering Transcutaneous Auricular Neurostimulation as an Adjunct Non-Opioid Pain Management Therapy for Patients Undergoing Lumbar Surgery", is to demonstrate whether transcutaneous…
- Conditions
- Pain, Postoperative, Opioid Use, Lumbar Spine Injury
- Trial name
- NCT06100172
- Testing
- Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Prostate Cancer, Spine, Open
Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery
The primary endpoint of this study is the completion time of hemostasis treatment when administered Fresh frozen plasma (FFP) and frozen powder coagulation factor concentrate (PCC) in goal-directed bleeding management for…
- Conditions
- Prostate Cancer, Spine, Open, Hip Osteoarthritis, Knee Disease
- Trial name
- NCT06144099
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Cerebral Hypoxia During and/or Resulting From A Procedure
The Effects of Body Mass İndex On İntraabdominal Pressure And Regional Cerebral Oxygen Saturation İn Prone Position
A total of 40 ASA (American Society of Anesthesiology) physical status I-III who underwent lumbar disc hernia repair for one or two levels were included in this prospective study.
- Trial name
- NCT05392478
- Volunteers
- 40 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Spinal Fusion, Deformity of Spine
Pelvic Fixation and Fusion During Multilevel Spinal Surgery
PAULA aims to collect data on the safety, performance, and effectiveness of iFuse Bedrock Granite (GRANITE) in patients who have spinal fusion surgery with pelvic fixation/ fusion.
- Trial name
- PAULA (NCT05640908)
- Testing
- iFuse Bedrock Granite Implant System
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- SI-BONE, Inc.
Scoliosis, Kyphosis
Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery
Individuals who undergo spine surgery often have a significant loss of blood and may require multiple blood transfusions. Research has shown that epsilon-aminocaproic acid (EACA) may reduce the amount of blood lost during…
- Conditions
- Scoliosis, Kyphosis, Lordosis, Spondylitis
- Trial name
- NCT00320619
- Testing
- Epsilon-Aminocaproic Acid (EACA)
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pedicle Screw Fixation of Spine
Robotic-Assisted Pedicle Screw Placement in Spine Surgery
This prospective multicenter observational cohort study evaluates robotic-assisted pedicle screw placement compared with non-robotic-assisted techniques in spinal surgery.
- Trial name
- ROBOTICSS (NCT07461636)
- Testing
- Robotic-assisted pedicle screw placement
- Where
- 9 sites in Sweden
- Volunteers
- 7,200 people
- Sponsor
- Uppsala University
Traumatic Spinal Cord Injury
The Austrian Spinal Cord Injury Study
Traumatic spinal cord injury (tSCI) is a debilitating disease that leads to neurological deficits and often has long-term effects including severe lifelong disability.
- Trial name
- ASCIS (NCT03109782)
- Where
- 18 sites in Austria
- Volunteers
- 1,000 people
- Sponsor
- Paracelsus Medical University
Neuromuscular Scoliosis, Spine Deformity
Mini-invasive Spine Surgery for Neuromuscolar Scoliosis
Neuromuscular scoliosis (SNM) are deformities related to the impairment of normal function of the central nervous system (CNS) and/or peripheral nervous system (PNS) resulting in alterations to the of the functional unit…
- Conditions
- Neuromuscular Scoliosis, Spine Deformity, Surgery, Vertebral Fusion
- Trial name
- MISNM (NCT06367933)
- Testing
- mini-invasive spine surgery
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Istituto Ortopedico Rizzoli
Comparative Effectiveness Research, Regional Block
Serratus Posterior Superior Intercostal Plane Block Versus Erector Spinae Plane Block in Thoracic Spine Surgeries
Spinal surgeries coincide with high level of pain due to extensive dissection and muscle retraction so inadequate pain control delays patient recovery, rehabilitation and also is an important source of patient dissatisfaction…
- Trial name
- NCT07646184
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Erector spinae block
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tanta University
Pain, Postoperative
Dexmedetomidine for Improved Pain Relief and Recovery in Spine Surgery
Chronic low back pain (CLBP) is a prevalent condition causing significant pain, disability, and reduced quality of life. While various treatments like exercise, NSAIDs, and spinal manipulation are recommended, their effectiveness…
- Trial name
- NCT06685081
- Testing
- Dexmedetomidine, lidocaine and triamcinolone
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Menoufia University
Lumbar Degenerative Disc Disease
Ultrasound as Adjunct Therapy for Increasing Fusion Success After Lumbar Surgery
Adjunct therapy for increasing posterolateral fusion success following single level posterior instrumented lumbar surgery.
- Trial name
- EXO-SPINE (NCT00744861)
- Testing
- Exospine, Exogen 4000+
- Volunteers
- 328 people
- Sponsor
- Bioventus LLC