Clinical trials: Spine Surgery
Opioid Free Anesthesia, Opioid Based Anesthesia
Intraoperative Infusion of Dexmedetomidine Versus Lidocaine or Magnesium Sulphate for Enhanced Quality of Recovery After Spine Surgery Fixation
Thoracolumbar fixation is a major spine surgery; it is performed to stabilize the spine after trauma, deformity or advanced degenerative disease.
- Conditions
- Opioid Free Anesthesia, Opioid Based Anesthesia, Spine Fixation Surgeries, Opiod-Related Disorders
- Trial name
- NCT07843953
- Testing
- Group ( L): LICOCAINE, GROUP Dexmedetomidine, Group M: Magnesium sulphate
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Surgical Blood Loss, Spinal Surgery
Efficacy of Suction Enabled Retraction Device
This is a prospective randomized controlled trial of the Suction-Integrated Surgical Tissue Elevator \& Retractor [SISTER] device to assess: Effects on operative time and efficiency of exposure in open lumbar spine cases.
- Trial name
- NCT03160170
- Testing
- SISTER device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spine Fusion
Steroids After Spine Fusion Surgery
This trial studies how well low-dose postoperative corticosteroids (FDA approved) affect patient outcomes (patient reported outcomes, pain medication use, length of stay, major complications, and time to first bowel movement)…
- Trial name
- NCT04568837
- Testing
- Prednisone 20 Mg
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Erector Spina Plan Block
The Effect of bılateral Erector spına Plan Block on postoperatıve paın ın spınal Surgery
Patients undergoing lumbar spinal stabilization surgery may experience severe postoperative pain lasting at least three days. Analgesia after lumbar stabilization surgery is beneficial for early recovery and is therefore…
- Trial name
- ESPB (NCT07537647)
- Testing
- UNDER ULTRASOUND GUİDANCE ESPB BLOCK, PROCEDURE/SURGERY: ERECTOR SPİNAE (ESP) BLOCK WİTH BUPİVACAİNE
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Surgery
A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.
Determine the optimal dose of IV N-acetylcysteine (NAC) to produce opioid reduction following spine surgery and estimate the difference in opioid consumption between placebo and the selected optimal dose.
- Trial name
- NCT04562597
- Testing
- Dose Response Curve N-acetylcysteine 50 mg/kg, Dose Response Curve N-acetylcysteine 100 mg/kg, Dose Response Curve N-acetylcysteine 150 mg/kg
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cervical Disc Disease
Driving After Cervical Spine Surgery
This is a single-center, prospective controlled simulation study designed comparing and evaluating the driving performance of subjects who have had cervical spine surgery and the use of a validated driving simulator.
- Trial name
- NCT02782923
- Testing
- STISIM driving simulator
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Physical Capability Outcomes
Physical Capability Outcomes After Single-Level PD-L vs Single-Level ALIF: a Multi-Center Clinical Trial
The purpose of this study is to compare the physical capability outcomes of patients who undergo single-level ProDisc-L disc replacement with those of patients who undergo stand-alone, single-level anterior lumbar interbody…
- Trial name
- NCT01055574
- Where
- 6 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gundersen Lutheran Medical Foundation
Degenerative Lumbar Spondylolisthesis
Degenerative Spondylolisthesis; Micro-decompression vs Decompression + Instrumented Fusion; Long Term Follow up
In many countries a majority of patients with degenerative spondylolisthesis are operated on with decompression plus instrumented fusion, but the scientific evidence for adding fusion is controversial.
- Trial name
- DS-registry (NCT03469791)
- Testing
- Surgical treatment of Degenerative Spondylolisthesis
- Where
- Norway
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Dural Tear, Bedrest
Symptom Prevalence and Severity in Lumbar Spine Surgery With and Without Dura Rupture
The primary purpose of this study is to assess whether lumbar spine surgery patients with dura rupture differ in symptom prevalence and severity from other lumbar spine surgery patients in the early postoperative phase.
- Conditions
- Dural Tear, Bedrest, Lumbar Spine Surgery
- Trial name
- NCT04794166
- Where
- Denmark
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Postoperative
Effect of Fu's Subcutaneous Needling on Postoperative Acute Pain in Patients With Lumbar Spine Surgery.
The goal of this clinical trial is to evaluate Fu's Subcutaneous Needling (FSN) in postoperative pain in patients with Lumbar Spine Surgery (LSS).
- Trial name
- NCT05572931
- Testing
- Fu's Subcutaneous Needling(FSN), fine acupuncture needle
- Where
- Taiwan
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Spine Deformity
A Prospective Randomized Study on the Clinical Benefits of OrthoPAT Drains
The examination of the ability of the OrthoPAT® blood collection device to decrease the transfusion rate and volume of adults undergoing posterior spine surgery for deformity correction of 6 levels or more.
- Trial name
- NCT02286102
- Testing
- OrthoPAT, Constavac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Low Back Pain and Core Muscle, Disc Herniation
Neural Control and Mechanosensation in Spine Muscle
Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization.
- Trial name
- NCT07003802
- Testing
- Resistance exercise
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Postoperative Pain
Effect of Lidocaine Versus Magnesium on Postoperative Pain in Spine Surgery
The goal in this work is to compare the effect of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status and quality of life in patients…
- Trial name
- NCT04776369
- Testing
- Lidocaine IV, Magnesium Sulfate Injection, IV saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Haitham Mohammad Ahmad Mohammad
Pain Management, Analgesia
Post-Operative Pain Management Following Spine Surgery
The primary objective of this pilot study is to assess the feasibility of comparing two standardized approaches to manage post-operative pain following spine surgery: one approach using Patient Controlled Analgesia (PCA) devices…
- Conditions
- Pain Management, Analgesia, Anesthetic
- Trial name
- EXPAREL (NCT03076710)
- Testing
- Opioids delivered through PCA, EXPAREL® infiltration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Post Operative Pain, Spinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and…
- Trial name
- MEND (NCT07222072)
- Testing
- Methadone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Infection
Analysis of the Incidence of Post-Operative Wound Infections After Spine Surgery
Post-operative wound infections can prolong hospital stays, increase rates of readmission to the intensive care unit, and increase the costs of treatment significantly.
- Trial name
- NCT02891486
- Testing
- Spinal surgery
- Where
- 2 sites in United States
- Volunteers
- 6,959 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hypertension
Cognitive Dysfunction in Hypertensive Patients Having Spine Surgery
While hypotension during general anesthesia has routinely been considered to be a tolerable abnormality with little clinical consequence, the proposed study takes the innovative approach of defining hypotensive events within the…
- Trial name
- HTN (NCT01140854)
- Testing
- Lumbar spine surgery, Neurologic/neuropsychometric examinations
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Columbia University
Lumbar Spinal Stenosis, Spinal Instability
Flexion-Extension Radiograph Imaging Protocol Reliability Study
Orthopedic surgeons often face the dilemma of whether to add fusion to a decompression procedure of the spine. Their decision mainly relies on personal experience to determine if a level is unstable preoperatively or if a…
- Trial name
- NCT05633550
- Testing
- Flexion-extension radiographs
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Dysphagia
Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal)
This prospective, randomized, double blind, controlled study evaluates the effect of a single dose of perioperative IV steroid versus saline on swallowing after anterior cervical spine surgery
- Trial name
- NCT03711474
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Surgical Field Quality Improvement in Spine Surgeries
Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries
The most common procedure said to involve substantial bleeding is spine surgery. There is always a significant danger of bleeding and blood transfusion associated with these procedures, particularly complex and multilevel spine…
- Trial name
- NCT06587620
- Testing
- Tranexamic acid, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Zagazig University