Clinical trials: Splenectomy
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cirrhosis, Splenectomy; Status
Apixaban, Warfarin and Aspirin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy（ESAWAAPT）
The purpose of this study is to determine whether Apixaban, Warfarin and Aspirin Anticoagulation are effective and safe in Prevention of Portal Vein Thrombosis in Liver Cirrhotic Patients after Laparoscopic Splenectomy
- Conditions
- Cirrhosis, Splenectomy; Status, Venous Thrombosis, Hypertension, Portal
- Trial name
- NCT04645550
- Testing
- Apixaban, Warfarin, Aspirin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Northern Jiangsu People's Hospital
Immune Thrombocytopenia (ITP)
Rituximab as Second Line Treatment for ITP
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized thrombocytopenia. Splenectomy is the standard treatment for patients who fails the first-line treatment: corticosteroid.
- Trial name
- NCT00344149
- Testing
- Rituximab (Mabthera)
- Where
- Norway
- Volunteers
- 112 people
- Sponsor
- Ostfold Hospital Trust
Idiopathic Thrombocytopenic Purpura
Comparative Study of Clinical Efficacy and Safety of GNR-069 and Nplate in Patients With ITP
It is a phase III multicenter randomized double-blinded comparative study of clinical efficacy and safety of GNR-069 and Nplate in patients with idiopathic thrombocytopenic purpura
- Trial name
- NCT05220878
- Testing
- GNR-069, Nplate
- Where
- 18 sites in Russia
- Volunteers
- 160 people
- Sponsor
- AO GENERIUM
End Stage Liver Disease
Splenectomy During Whole Liver Transplantation
Indications for splenectomy during whole liver transplantation remain controversial and splenectomy is often avoided because of common complications.
- Trial name
- NCT03609411
- Testing
- Splenectomy
- Where
- France
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Liver Cirrhosis
A Clinical Trial of the Vessel Sealing System (LigaSure) in Azygoportal Disconnection and Splenectomy in Patients With Portal Hypertension
The aim of this trial was to verify the efficiency of a new surgical device (the LigaSure vessels sealing system) in esophagogastric decongestion and splenectomy in patients with portal hypertension.
- Trial name
- NCT00965744
- Testing
- Vessel sealing system LigaSure
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Changzheng Hospital
Hypertension, Portal, Portal Vein, Cavernous Transformation Of
Percutaneous Transhepatic Intrahepatic Portosystemic Shunt for Treatment of Portal Vein Occlusion With Symptomatic Portal Hypertension After Splenectomy
To evaluate the values of percutaneous transhepatic intrahepatic portosystemic shunt for treatment of portal vein occlusion with symptomatic portal hypertension after splenectomy.
- Trial name
- NCT02505152
- Testing
- Percutaneous transhepatic intrahepatic portosystemic shunt
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Hereditary Spherocytosis, Idiopathic Thrombocytopenic Purpura
Single Incision Versus Standard Laparoscopic Splenectomy
This is a prospective trial of single incision versus standard 4-port laparoscopic splenectomy. The hypothesis is that there may be a difference in wound infection rates, operative time, doses of analgesics post-operatively, and…
- Trial name
- NCT01276561
- Testing
- Single Incision Splenectomy, Laparoscopic Splenectomy
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Thrombocytopenia, Idiopathic Thrombocytopenic Purpura
AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Refractory to Splenectomy
The purpose of this study is to evaluate the efficacy of AMG 531 in the treatment of thrombocytopenia in subjects with ITP as measured by the platelet response.
- Trial name
- NCT00102323
- Testing
- AMG 531
- Volunteers
- 63 people
- Sponsor
- Amgen
Pulmonary Disease, Postoperative Respiratory Complications
Screening of Postoperative Pulmonary Complications by Electrical Impedance Tomography
The purpose of this study is to determine whether Electrical Impedance Tomography can be used as sensitive and specific predictor in the detection of postoperative pulmonary complications (e.g.
- Conditions
- Pulmonary Disease, Postoperative Respiratory Complications, Malignant Neoplasm of Stomach, Liver Diseases
- Trial name
- NCT02337673
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Johannes Gutenberg University Mainz
Left-sided Pancreatic Cancer, Ductal Adenocarcinoma
Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
When distal pancreatectomy is carried out for left-sided pancreatic cancer, splenectomy is usually performed not only for margin-negative resection but also for effective clearance of the splenic hilar lymph nodes.
- Trial name
- NCT01875198
- Testing
- Radical Antegrade Modular Pancreatectomy with Splenectomy, Radical Antegrade Modular Pancreatectomy without splenectomy
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Yonsei University
Sickle Cell Anemia, Thalassemia
The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia
The spleen in Sickle Cell Anemia and Sickle Cell Thalassemia is usually enlarged in the first years of life but the immune protection provided is considered insufficient.
- Trial name
- NCT00971698
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Grade III Traumatic Splenic Injury in Hemodynamically Stable Patients
Traumatic Injury of Spleen:Laparoscopic Splenectomy Vs Splenic Artery Embolization
The goal of this clinical trial is selection of the best method in management of grade 3 traumatic Splenic Injury in Hemodynamically Stable Patients thus improving the quality of life and clinical outcome.
- Trial name
- NCT07274007
- Testing
- Laparoscopic Splenectomy vs splenic Artery Embolization
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Primary Immune Thrombocytopenia
Observational Study on the Outcome of Patients With ITP Who Underwent Splenectomy After 2010
Retrospective data collection on ITP patients who underwent splenectomy from 01/01/2010 to 12/31/2022. The expected enrollment period is 6 months. The observation period of the enrolled patients is at least 1 year.
- Trial name
- NCT06466824
- Volunteers
- 157 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Trauma Splenic
Long Term Effect of Splenectomy on Metabolism
Metabolic status of patients who had gone through trauma splenectomy between July 2008 and July 2013 were compared to patients who had gone through bowel resection due to obstruction in the same period of time.
- Trial name
- NCT03648307
- Testing
- Blood sample
- Volunteers
- 154 people
- Sponsor
- Imam Hossein General Hospital
Splenectomized Patients
Post Splenectomy Care Assessment and the Role of Patient Education in Its Improvement
The goal of this trial is to evaluate compliance to booster vaccines and chemoprophylaxis in children who underwent a splenectomy and to assess the knowledge regarding this aspect before and after giving education.
- Trial name
- NCT07027371
- Testing
- Health education
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Cairo University
Dexmedetomidine, External Oblique Intercostal Plane Block
Different Doses of Dexmedetomidine in External Oblique Intercostal Plane Block in Splenectomy
The aim of this study is to compare the analgesic effects of different doses of dexmedetomidine as an adjuvant in external oblique intercostal plane block (EOIPB) in splenectomy.
- Conditions
- Dexmedetomidine, External Oblique Intercostal Plane Block, Splenectomy
- Trial name
- NCT06363578
- Testing
- Dexmedetomidine 0.5 μg/kg, Dexmedetomidine 1 μg/kg
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Liver Transplantation
A Study of TCD601 in the Induction of Tolerance in de Novo Liver Transplantation
The purpose of this study is to evaluate if treatment with a siplizumab-based regimen can induce allogeneic tolerance in liver transplant recipients.
- Trial name
- NCT06019507
- Testing
- TCD601, Cyclophosphamide, TAC
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- ITB-Med LLC
Splenic Trauma
Benefit of Prophylactic Embolization of the Splenic Salvage
The main objective is to show that splenic embolization improves salvage rate at one month in a population of hemostatically stable closed splenic trauma patients with a high risk of splenectomy
- Trial name
- Splash (NCT02021396)
- Testing
- Embolization
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Grenoble
Gut Microbiota, Spleen Injury
Microbiota is Related With Increasing Infection Rates After Splenectomy
Studies has shown an increasingly infection rate after splenectomy, and there is a potential correlation between microbiota and immune system.
- Conditions
- Gut Microbiota, Spleen Injury, Infection
- Trial name
- NCT03420599
- Testing
- splenectomy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University