Clinical trials: Split-dose Bowel Preparation
Colo-rectal Cancer, Colonic Neoplasms
Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting
Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority.
- Trial name
- NCT03816774
- Testing
- PEG split-dose and simethicone
- Where
- Portugal
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Colonoscopy
The Comparative Study Between Bowel Preparation Method
The purpose of this study is to compare the efficacy, acceptability and preparation-induced mucosal inflammation of PEG + ascorbic acid vs. PEG for colonoscopy.
- Trial name
- CSBPM (NCT01964417)
- Testing
- Colonoscopy after bowel cleansing
- Where
- South Korea
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Inje University
Elective Colonoscopy
Efficacy and Safety of mAnnitol in Bowel Preparation During Elective Colonoscopy and Comparison With Moviprep®
The purpose of this dose finding/comparative efficacy study is to first single out the most appropriate dose of mannitol for bowel preparation (phase II) and, subsequently, demonstrate the non-inferiority of the efficacy of…
- Trial name
- SATISFACTION (NCT04759885)
- Testing
- Phase II: NTC015 low dose, Phase II: NTC015 medium dose, Phase II: NTC015 high dose
- Where
- 35 sites in France, Germany and 2 more
- Volunteers
- 886 people
- Sponsor
- NTC srl
Colon Cancer Screening
Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy
Colorectal cancer is the second leading cause of cancer deaths that could be prevented in the United States. Colonoscopy is the best test for finding and removing polyps before they turn into cancer.
- Trial name
- NCT07320989
- Testing
- Chewing Sugar-Free Gum During Bowel Preparation, Standard Bowel Prep (2L PEG-ELP), Standard Bowel Prep
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Colonoscopy
A Pre-endoscopic Prediction Model for Inadequate Bowel Preparation in Patients Receiving Split Dose Polyethylene Glycol Preparation
After written consent for participating in clinical research studies, all clinical studies conducted to in the one day. The investigators will ask and record about bowel cleansing state in all patients who performed colonoscopy.
- Trial name
- NCT02174601
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Bowel Preparation for Colonoscopy
Low-volume Polyethylene Glycol Bowel Preparation for Colonoscopy
the efficacy and tolerability of a low-volume (2 L) PEG regimen for colonoscopy compared to single (4 L) or split-dose (2 L + 2 L) treatments are not different.
- Trial name
- NCT01929590
- Testing
- PEG-3350 group 2, PEG-3350 group 1, PEG-3350 group 3
- Where
- Mexico
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Colon Cleansing
PMC Split Preparation for Colon Cleansing
This is an endoscopist-blinded, prospective, multicenter study involving adult outpatients aiming at evaluating whether sodium picosulphate/magnesium citrate split dosing is associated to higher efficacy and acceptability in…
- Trial name
- MAGIC-P (NCT01909219)
- Testing
- Sodium picosulphate/magnesium Citrate
- Where
- 2 sites in Italy
- Volunteers
- 862 people, healthy volunteers welcome
- Sponsor
- Luigi Sacco University Hospital
Bowel Preparation
Comparing Single-dose Low-volume PEG Plus Bisacodyl vs. Split-dose PEG for Bowel Preparation in Morning Colonoscopy
Colonoscopy is the best method to detect colorectal cancer and colonic polyps. Studies showed that adenoma detection rate positive correlation with good bowel preparation which makes bowel preparation an important issue.
- Trial name
- NCT03248726
- Testing
- Polyethylene glycol and bisacodyl, Split-dose polyethylene glycol
- Where
- Taiwan
- Volunteers
- 122 people
- Sponsor
- Taipei Medical University WanFang Hospital
Colorectal Cancer
Comparative Effectiveness of Split-Dose Colonoscopy Bowel Preparation Regimens
From the patients' perspective, the most formidable part of the colonoscopy experience is the process of bowel cleansing. A poorly tolerated bowel preparation regimen often leads to incompletion of scheduled colonoscopies which…
- Trial name
- NCT03298945
- Testing
- Miralax-Gatorade Prep, Golytely
- Where
- United States
- Volunteers
- 2,239 people
- Sponsor
- VA Office of Research and Development
Bowel Preparation, Efficacy, Tolerability, Safety
Efficacy, Safety and Tolerability of Split-dose of PEG Compared With NaP Solution for Colonoscopy Preparation: A Randomized, Controlled Trial
: In several studies comparing of sodium phosphate solutions versus PEG, both regimen had similar efficacy of bowel cleansing and sodium phosphate solutions are more acceptable to patients because patient are required to consume…
- Trial name
- SPEN (NCT01229800)
- Testing
- Polyethylene glycol, Sodium phosphate(NaP) solution
- Where
- South Korea
- Volunteers
- 207 people
- Sponsor
- Inje University
Bowel Preparation
Investigation of PicoPrep Versus HalfLytely for Bowel Preparation for Colonoscopy - Split Dose PicoPrep
Subjects undergoing an elective complete colonoscopy will randomly receive either PicoPrep: 2-sachets for oral solution in two divided doses given a night before (first dose - sachet) and approximately 5 hours prior to procedure…
- Trial name
- NCT01073930
- Testing
- PicoPrep, HalfLytely, bisacodyl
- Where
- 9 sites in United States
- Volunteers
- 608 people
- Sponsor
- Ferring Pharmaceuticals
Gastrointestinal Hemorrhage, Colon Cancer
Bowel Preparation for Inpatient Colonoscopy
This study will compare two strategies for bowel cleansing prior to inpatient colonoscopy: the entire preparation taken the night before the procedure versus half the preparation taken the night before the procedure, and the…
- Conditions
- Gastrointestinal Hemorrhage, Colon Cancer, Diverticulosis
- Trial name
- NCT01169220
- Testing
- Go-Lytely, Go Lytely
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Santa Clara Valley Health & Hospital System
Bowel Cleansing, Colonoscopy
Efficacy and Safety of Split-dose Citrafleet Administered From 2 to 6 Hours Before Morning Colonoscopies
An excellent bowel cleansing is mandatory to increase the diagnostic accuracy of colonoscopy. Failure to adequately cleanse the bowel for colonoscopy can lead to missed lesions, prolonged procedure duration and repeated…
- Trial name
- NCT01481714
- Testing
- Sodium picosulphate, magnesium oxid and citric acid, Sodium picosulphate/magnesium oxide and citric acid
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Infante, Javier Molina, M.D.
Bowel Preparation
Split-dose Versus Single-dose Polyethylene Glycol Regimen for Capsule Endoscopy
To compare the small bowel cleanliness for wireless capsule endoscopy using two different Polyethylene Glycol administration schedules (before the wireless capsule endoscopy ingestion versus in a split-dose fashion).
- Trial name
- NCT02396017
- Testing
- Capsule endoscopy, Polyethylene Glycol
- Where
- Portugal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Ocidental
Health Behavior
Comparison of Two Methods for Bowel Preparation in Patients With Constipation
Constipation is a common high risk factor for inadequate bowel preparation. The bowel cleansing efficacy of the standard split-does of 4L seems to be suboptimal in constipated patients.
- Trial name
- NCT03306030
- Testing
- Split dose of 4L PEG, Three times dose of 4L PEG
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Air Force Military Medical University, China
Colonoscopy, Bowel Preparation
Efficacy of Prokinetics With Split Dose of PEG in Morning Colonoscopic Bowel Preparation
In bowel preparation using split dose PEG, various adjuncts to colonic cleansing were proposed to improve colonic preparation cleansing. Prokinetics, as an adjunct, was included in a few studies.
- Trial name
- PSPEG (NCT01513096)
- Testing
- itopride
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Inje University
Colonoscopy Preparation
4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy
The goal of this randomized controlled trial is to compare the safety, compliance, and efficacy of different bowel preparation methods prior to colonoscopy.
- Trial name
- NCT07328880
- Testing
- 4-L split-dose polyethylene glycol and Bisacodyl + Docusate sodium., 2-L split-dose polyethylene glycol plus Oral Simethicone regimen ., 2-L split-dose polyethylene glycol regimen
- Where
- Egypt
- Volunteers
- 450 people
- Sponsor
- Tanta University
Colonoscopy Preparation
Single Dose Versus Split Dose Polyethylene Glycol-based Colonic Lavage for Colonoscopy
Proper bowel cleansing prior is an essential requirement for the conduct of colonoscopy. However, due to the nature of cleansing process, the ideal bowel cleansing preparation remains elusive.
- Trial name
- NCT01610856
- Testing
- Polyethylene Glycol
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Bowel Preparation Solutions, Colonoscopy
Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC)
4L split dose PEG is the gold standard for bowel preparation, however it comes with poor tolerability and poor compliance. Combination of PEG with different agent is useful in reducing total volume, improving compliance and…
- Trial name
- NCT04474002
- Testing
- 4L Klean Prep®, 1L Klean prep® and 2 sachets Picoprep®
- Where
- Hong Kong
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Colonic Adenoma, Bowel Preparation
Efficacy of Split-dose of Oral MMS for Bowel Preparation in Elderly Patients
Adequate bowel preparation is critical for successful colonoscopy and a large volume of PEG was required for bowel preparation in patients undergoing colonoscopy.
- Trial name
- NCT04948567
- Testing
- split-dose of Magnesium Sulfate solution, split-dose of PEG
- Where
- 2 sites in China
- Volunteers
- 1,174 people
- Sponsor
- Air Force Military Medical University, China