Clinical trials: Spondylarthropathies
Axial Spondyloarthritis
A Study to Assess the Effectiveness of Certolizumab Pegol in Patients With Axial Spondyloarthritis in Daily Life
The primary purpose is to assess the effectiveness of certolizumab pegol in patients with axial spondyloarthritis under routine clinical practice.
- Trial name
- CIMAX (NCT02354105)
- Where
- 100 sites in Belgium, Germany and 4 more
- Volunteers
- 680 people
- Sponsor
- UCB Biopharma S.P.R.L.
Osteoarthritis, Knee, Rheumatoid Arthritis
Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis
Osteoarthritis (OA) is a condition affecting the whole joint and is a major cause of pain and disability worldwide. Although OA is very common, the initial steps which lead to the development of pain and tissue damage are not…
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- ARPAIN (NCT03533569)
- Testing
- Intra-articular corticosteroid injection
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Ankylosing Spondylitis
A Study of Infliximab (Remicade) in Patients With Ankylosing Spondylitis.
A study of the safety and efficacy of Infliximab (Remicade) versus placebo in subjects with Ankylosing Spondylitis
- Trial name
- NCT00207701
- Testing
- infliximab
- Volunteers
- 279 people
- Sponsor
- Centocor, Inc.
Arthritis, Rheumatoid, Arthritis, Psoriatic
Characterization of Immunogenicity of TNF Inhibitors in Arthritis Patients With Poorer Treatment Response.
The aim of the study is to explore whether the influence of gender, tobacco smoking and obesity on treatment response in tumor necrosis factor inhibitors (TNFIs) can be explained by high degree of inflammation, human leucocyte…
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Spondylitis, Ankylosing
- Trial name
- NCT04731831
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aalborg University Hospital
Spondyloarthropathy, Fibromyalgia
Ultrasound Assessment of Entheseal Sites in Patients with Seronegative Spondyloarthropathy with or Without Fibromyalgia
Seronegative spondyloarthropathies are a family of joint disorders that classically include ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD) associated arthritis, reactive arthritis…
- Trial name
- NCT06495866
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Sohag University
Spondyloarthritis
A Study of Ixekizumab (LY2439821) in Chinese Participants With Radiographic Axial Spondyloarthritis
The main purpose of this study is to evaluate the efficacy and safety of ixekizumab in Chinese participants with radiographic axial spondyloarthritis (r-axSpA).
- Trial name
- NCT04285229
- Testing
- Ixekizumab
- Where
- 19 sites in China
- Volunteers
- 147 people
- Sponsor
- Eli Lilly and Company
Axial Spondyloarthritis
A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis
This study will compare the Non Steroidal Anti-Inflammatory Drugs (NSAIDs) sparing effect of etanercept with that of placebo in adult subjects with axial Spondyloarthritis.
- Trial name
- SPARSE (NCT01298531)
- Testing
- etanercept
- Where
- 19 sites in France
- Volunteers
- 90 people
- Sponsor
- Pfizer
Spondyloarthritis (SpA), Ankylosing Spondylitis (AS)
Effect and Safety of Benzathine Penicillin Combined With Etanercept on Spondyloarthritis
The purpose of the study is to verify the clinical feasibility of Benzathine penicillin (BPG) /Etanercept (ETN) combination regimen in patients with spondyloarthritis (SpA) and at the same time compare Benzathine penicillin…
- Trial name
- NCT06707194
- Testing
- Etanercept, Benzathine Penicillin
- Where
- 6 sites in China
- Volunteers
- 340 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Spondylitis, Ankylosing
Prediction of the Answer to the Treatment by Biotherapies for Naive Spondyloarthritis by Combinatorial Analysis of Serum Biomarkers
The aim of this trial is the caracterisation of a predicting algorithm of the answering response for patients with etanercept treatment in spondyloarthritis disease.
- Trial name
- PRESA (NCT03033095)
- Testing
- Etanercept ® 50 mg
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Inflammatory Bowel Disease
Analysis of Birth Outcomes of Swedish, Danish and Finnish Women Exposed to Remicade With Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Psoriasis
The purpose of this study is collection and analysis of information pertaining to pregnancy outcomes in women exposed to infliximab during pregnancy, relative to the background risk in similar but non-biologic exposed patients…
- Trial name
- NCT00658827
- Testing
- No intervention
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Janssen Biotech, Inc.
Axial Spondyloarthritis
High-intensity Training in Patients With Spondyloarthritis: a Randomized Controlled Trial
Project summary Background: For people diagnosed with a spondyloarthritis (SpA) e.g. ankylosing spondylitis or undifferentiated spondyloarthritis, physical activity and exercise are important components in the self-management.
- Trial name
- NCT05781763
- Testing
- High intensity interval training (HIIT), Control group
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Halmstad University
Spondylitis, Ankylosing
16-week Efficacy and 3-year Safety, Tolerability and Efficacy of Secukinumab in Active Ankylosing Spondylitis Patients
The purpose of this study was to generate 16-week efficacy data, as well as up to 3-year efficacy, safety and tolerability data in subjects with active AS despite current or previous NSAID, DMARD and/or anti-TNF therapy.
- Trial name
- MEASURE 3 (NCT02008916)
- Testing
- Secukinumab
- Where
- 57 sites in United States, Belgium and 8 more
- Volunteers
- 226 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Rheumatoid Arthritis
Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers.
The purpose of this study is to evaluate the incidence of gastric ulcers following administration of either PN 200 or Naproxen in subjects who are at risk for developing NSAID-associated ulcers.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- NCT00367211
- Testing
- PN 200 tablets (500 mg naproxen and 20 mg omeprazole), Naproxen 500 mg tablets (PN 200 minus omeprazole)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- POZEN
Psoriatic Arthritis
Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis
The purpose of this study is: To elucidate the immunomodulating properties of anti-TNF-α therapy in patients with psoriatic arthritis (PsA).
- Trial name
- NCT00432406
- Testing
- Infliximab, Etanercept
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Arthritis, Rheumatoid, Arthritis, Psoriatic
PANLAR's Latin American Registry of Rheumatic Patients Treated With Jak Inhibitors
This prospective, non-interventional, research registry is designed to study the comparative safety and comparative effectiveness of approved Jak Inhibitors treatment for RA-PsA-SpA in a cohort of patients and theirs controls…
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Spondyloarthritis
- Trial name
- PREJAK (NCT04821206)
- Testing
- DMARDs, biologic DMARDs, JAK Inhibitor
- Where
- 2 sites in Argentina
- Volunteers
- 3,000 people
- Sponsor
- Liga Panamericana de Asociaciones de Reumatologia (PANLAR)
Ankylosing Spondylitis
Study To Evaluate The Impact Of Early Initiation Of Biological Treatment With Ankylosing Spondylitis
This study is to evaluate available data in Iraqi patients with ankylosing spondylitis on Enbrel treatment with regards to the impact of early treatment using data from the Baghdad Teaching Hospital registry
- Trial name
- NCT04507763
- Testing
- Etanercept
- Where
- Iraq
- Volunteers
- 763 people
- Sponsor
- Pfizer
PsA (Psoriatic Arthritis)
Effect of Metformin on Carotid Atherosclerosis for Non-diabetic Patients With PsA (CAMPA Study)
Background: Psoriatic arthritis (PsA) is a common chronic inflammatory disease with a prevalence up to 670 every 100,000 subjects.
- Trial name
- NCT05988684
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- Chinese University of Hong Kong
Rheumatoid Arthritis, Palindromic Arthritis
Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity
Social determinants of health (SDoH), defined by the World Health Organization as "the conditions in which people are born, grow, work, live and age and the wider set of forces and systems shaping the conditions of daily life"…
- Conditions
- Rheumatoid Arthritis, Palindromic Arthritis, Juvenile Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- RAISE (NCT05715463)
- Testing
- Resource sheets, Community Resource Specialist, Nurse Navigator
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis, Bone Resorption
Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are characterized by chronic systemic inflammation and share common pathogenic pathways.
- Conditions
- Rheumatoid Arthritis, Bone Resorption, Ankylosing Spondylitis
- Trial name
- NCT01417455
- Where
- Portugal
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Instituto de Medicina Molecular João Lobo Antunes
Ankylosing Spondylitis (AS)
A Study Evaluating the Efficacy of Secukinumab 300mg in Chinese Adults With Active Ankylosing Spondylitis
The purpose of this study is to evaluate the safety and efficacy of secukinumab 300mg in Chinese adults participants with active ankylosing spondylitis (AS) who have had an inadequate response to at least 2 non-steroidal…
- Trial name
- NCT05303285
- Testing
- Secukinumab 300mg s.c., Secukinumab 150mg s.c.
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital