Clinical trials: Spondyloarthritis, Axial
Systemic Lupus Erythematosus, Sjogren's Syndrome
COVID-19 Vaccination in Rheumatic Disease Patients
The research is being done to study the immune responses to COVID-19 vaccination in patients with rheumatic diseases.
- Conditions
- Systemic Lupus Erythematosus, Sjogren's Syndrome, Inflammatory Myositis, Psoriatic Arthritis
- Trial name
- NCT04839315
- Testing
- mRNA COVD19 vaccine
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Spondylitis, Ankylosing
Novel Quantitative MRI for Axial Spondyloarthritis
This proposal aims to develop novel MR imaging and image processing techniques that will provide reliable and fully quantitative evaluation of inflammation, chronic structural changes and vascularity in patients with Ankylosing…
- Trial name
- NCT03778515
- Testing
- MRI
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Axial Spondyloarthritis, Ankylosing Spondylitis
Osteosarcopenia in Axial Spondyloarthritis
Axial spondyloarthritis is a chronic inflammatory disease affecting the spine, sacroiliac joints, entheses, and sometimes peripheral joints with a close link to HLAB27.
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, Axial Spondyloarthritis, Non-Radiographic, Osteoporosis
- Trial name
- NCT06577350
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Ankara University
Carotid Artery Plaque, Ankylosing Spondylitis
Effects of Rosuvastatin on Carotid Artery Plaques in Patients With Inflammatory Joint Disease
Patients with rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) are at greater risk of developing cardiovascular disease.
- Conditions
- Carotid Artery Plaque, Ankylosing Spondylitis, Rheumatoid Arthritis
- Trial name
- RORAAS (NCT01389388)
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 114 people
- Sponsor
- Diakonhjemmet Hospital
Non-radiographic Axial Spondyloarthritis, Ankylosing Spondylitis
Evaluation of Spine Posture, Trunk Position Sense and Gait in Axial Spondyloarthritis Patients
Axial Spondyloarthritis (Ax-SpA) are chronic systemic inflammatory rheumatological diseases characterized by axial skeletal involvement and enthesitis. Sacroiliitis is the most prominent sign of the disease.
- Trial name
- NCT05038189
- Testing
- Gait parameters, Spine posture, Trunk position sense
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Inflammatory Arthritis
Allied Health in Rheumatology Triage Project
There is accumulating evidence that early treatment leads to better outcomes for patients with inflammatory arthritis (IA). Triage, which is the process of identifying the urgency of a patient's disease state efficiently and…
- Trial name
- AHRT (NCT02465879)
- Testing
- Therapist Triage
- Volunteers
- 295 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ankylosing Spondylitis, Rheumatoid Arthritis
Quality of Life in Chronic Arthritis
Chronic joint complaints are prevalent in clinical practice. If chronic arthritis such as rheumatoid arthritis (RA) or ankylosing spondylitis (AS) is not adequately controlled, it can not only affect patient's working ability but…
- Trial name
- NCT01357018
- Where
- Taiwan
- Volunteers
- 139 people
- Sponsor
- Far Eastern Memorial Hospital
Ankylosing Spondylitis
Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy
This is a prospective, randomized, open-label clinical trial to evaluate the efficacy and safety of total glucosides paeony capsules in maintaining clinical remission in patients with ankylosing spondylitis which achieved…
- Trial name
- NCT01517620
- Testing
- Total Glucosides Paeony Capsules
- Where
- 2 sites in China
- Volunteers
- 38 people
- Sponsor
- Sun Yat-sen University
Inflammatory Disorder of Immune System, Spondylitis, Ankylosing
Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases
Cannabis, in addition to its psychotropic properties, could have anti-inflammatory and immunomodulatory effects. Phytocannabinoids (pCBs) are a group of molecules naturally secreted by the cannabis plant.
- Conditions
- Inflammatory Disorder of Immune System, Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- pCB-IMIDs (NCT06842316)
- Testing
- 1 blood sample, 40 mL (collection during a blood test, part of the standard of care for this disease)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Spondylarthropathy, Sarcopenia
Sarcopenia in Axial and Peripheral Spondyloarthropathies
Spondylarthropathies (SpA) are among the most common chronic inflammatory rheumatisms in adults, responsible for a muscular loss or sarcopenia which can be very disabling, not much documented in the literature, and not yet…
- Trial name
- SASPAR (NCT03319264)
- Testing
- Dynamometry exam, Walking test, DXA measurement
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Hospices Civils de Lyon
Nonradiographic Axial Spondyloarthritis
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Nonradiographic Axial Spondyloarthritis
The purpose of the study is to demonstrate the efficacy, safety and tolerability of bimekizumab administered subcutaneously (sc) compared to placebo in the treatment of subjects with active nonradiographic axial spondyloarthritis…
- Trial name
- BE MOBILE 1 (NCT03928704)
- Testing
- Bimekizumab
- Where
- 83 sites in United States, Belgium and 11 more
- Volunteers
- 274 people
- Sponsor
- UCB Biopharma SRL
Rheumatoid Arthritis, Ankylosing Spondylitis
Artificial Intelligence Literacy and E-Health Literacy in Rheumatic Diseases
This study aims to evaluate digital health competencies in individuals with rheumatic and degenerative joint diseases. Specifically, it assesses e-health literacy and artificial intelligence literacy, which refer to individuals'…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Knee Osteoarthritis
- Trial name
- NCT07054749
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Seronegative Spondyloarthropathies
Combination Disease-Modifying Antirheumatic Drugs (DMARDs) Versus Sulfasalazine in Inflammatory Back Pain
Till now no drug has been conclusively shown to affect the natural course of the inflammatory back ache in seronegative spondylarthropathies.
- Trial name
- NCT01040195
- Testing
- Methotrexate, Hydroxychloroquine
- Where
- India
- Volunteers
- 33 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Ankylosing Spondylitis (AS)
Posture Exercises in Ankylosing Spondylitis
This study will evaluate the effects of posture-focused exercises on spinal alignment in patients with ankylosing spondylitis. Participants will be randomly assigned to one of two groups.
- Trial name
- AS-POSTURE (NCT07879157)
- Testing
- Standard Breathing Exercise Program, Posture-Focused Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Mustafa Akça
Ankylosing Spondylitis
Open Label Clinical Trial With Rituximab (MabThera ®) in Ankylosing Spondylitis
To evaluate the efficacy and safety of rituximab when added to NSAIDs and/ or methotrexate both for TNFalpha inhibitor naïve or TNFalpha inhibitor failure patients with moderate to severe ankylosing spondylitis
- Trial name
- NCT00432653
- Testing
- rituximab
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Spondylarthritis, Axial Spondyloarthritis
Clinical Trial of Electroacupuncture in Axial Spondyloarthritis (E-AcuSpA)
Axial spondyloarthritis (AxSpA) is a chronic disease that causes severe disability and poor quality of life. Current treatment options are limited and there are still significant non-responders to current western medications.
- Trial name
- E-AcuSpA (NCT04519866)
- Testing
- Electroacupuncture, Manual acupuncture
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Singapore General Hospital
Ankylosing Spondylitis
Neuropathic Spinal Pain Descriptors in Ankylosing Spondylitis
The investigators have aimed to explore and interpret the neuropathic pain (NP) descriptors of spinal pain in patients with ankylosing spondylitis (AS).
- Trial name
- NCT05096767
- Testing
- questionnaires and inventories
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Bozyaka Training and Research Hospital
Axial Spondyloarthritis
ToFAcitinib in Early Active Axial SpondyloarThritis:
This is a phase IV, multicentre, randomized, double-blind, placebo-controlled study designed to compare the efficacy and safety of tofacitinib versus placebo (on a background of an NSAID) over 16 weeks of treatment and 4 weeks of…
- Trial name
- FASTLANE (NCT06112665)
- Testing
- Tofacitinib 5 MG
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Axial Spondyloarthritis
AScalate: Treat-to-target in Axial Spondyloarthritis
This was a randomized, parallel-group, open-label, multicenter study in patients with active axSpA. The aim of the study was to demonstrate that the efficacy of a T2T approach (with secukinumab as a first-line biologic) was…
- Trial name
- AScalate (NCT03906136)
- Testing
- Secukinumab/Adalimumab-Biosimilar, Standard-of-care
- Where
- 47 sites in France, Germany
- Volunteers
- 304 people
- Sponsor
- Novartis Pharmaceuticals
Ankylosing Spondylitis
Safety and Efficacy of Allogeneic Bone Marrow MSCs in Ankylosing Spondylitis
The goal of this clinical trial is to learn if allogeneic human bone marrow-derived mesenchymal stem cells (CG-BM1) are safe and show preliminary efficacy in treating patients with ankylosing spondylitis (AS).
- Trial name
- NCT07632599
- Testing
- IV administration of CG-BM1, CG-BM1
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University