Clinical trials: Spontaneous Abortions
Abortion, Habitual
Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia
The prevalence of insulin resistance is increased in women with recurrent miscarriage compared with matched fertile controls,Insulin resistance (IR) in this syndrome is not only implicated toward early pregnancy loss (EPL) but…
- Trial name
- MetRPL (NCT01718340)
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Hyperinsulinemia, Miscarriages
Maternal Lifestyle and Neonatal Hypoglycemia
tPA has a pivotal role in placentation, mediationg activation of growth factors, such as vascular endothelial growth factor and brain-derived neurotrophic factor, degradation of extracellular matrix and basement membrane…
- Conditions
- Hyperinsulinemia, Miscarriages, Pregnancy, Sedentary Lifestyle
- Trial name
- NCT01409382
- Testing
- Daily brisk walking plus a carbohydrate-restricted diet
- Where
- Brazil
- Volunteers
- 480 people
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Recurrent Pregnancy Loss, Fetal Demise
Pharmacokinetics of Low Molecular Weight and Unfractionated Heparin in Pregnancy
To determine, through pharmacokinetic parameters, the ideal dosing protocol for dalteparin (a low molecular weight heparin) and unfractionated heparin for women desiring pregnancy who have evidence of an acquired (specifically…
- Conditions
- Recurrent Pregnancy Loss, Fetal Demise, Abortion, Habitual, Antiphospholipid Antibodies
- Trial name
- NCT00721591
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Recurrent Miscarriage
3D Ultrasound to Assess in Recurrent Miscarriage
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
- Trial name
- 3D-ARM (NCT06164015)
- Testing
- 3D Ultrasound scan with power Doppler angiography
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Abortion, Spontaneous, Abortion in First Trimester
Application of Lactobacillus Salivarius CECT5713 in Infertility of Unknown Origin
In this study, we aimed to assess the cervicovaginal environment (pH, Nugent score, soluble immune factors and bacterial profile) in women with reproductive failure because of either repetitive abortion or infertility of unknown…
- Conditions
- Abortion, Spontaneous, Abortion in First Trimester, Infertility Unexplained
- Trial name
- NCT04446572
- Testing
- Lactobacillus salivarius CECT5713
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Universidad Complutense de Madrid
Miscarriage, Recurrent
Sildenafil Citrate in Early Unexplained Recurrent Pregnancy Loss
Recurrent unexplained spontaneous miscarriage (RSM) is defined as three consecutive pregnancy loss prior to 20 weeks from the last menstrual period. 1% to 2% of women experience RSM. Treatment of URSM is a challenging issue.
- Trial name
- NCT03766594
- Testing
- Sildenafil Citrate, Folic Acid
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Incomplete Abortion
Misoprostol Treatment of Incomplete Abortion by Midwives and Physicians in Uganda
Uganda is one of the countries with highest fertility rate in the world, 6.7 children per women. It is estimated that 56 percent of all pregnancies are unintended and the contraceptive prevalence rate in Uganda is 23 percent.
- Trial name
- NCT01743508
- Testing
- Misoprostol treatment by midwife
- Where
- Uganda
- Volunteers
- 731 people
- Sponsor
- Karolinska Institutet
Pregnancy Loss, Miscarriage
Implantation Test for Endometrial Receptivity
Background Miscarriage is the most frequent complication of pregnancy and represents the spontaneous loss of the embryo or foetus before it is able to survive independently (24 weeks of gestation).
- Trial name
- NCT03442335
- Testing
- Chromohysteroscopy, Endometrial biopsy (Pipelle)
- Where
- 6 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Birmingham
Missed Abortion, Anembryonic Pregnancy
Ulipristal Acetate for Use in Early Pregnancy Loss
The investigators will study the feasibility of using 90mg ulipristal acetate, a selective progesterone receptor agonist, as an adjunct to 800mcg vaginal misoprostol for the medical management of early pregnancy loss.
- Conditions
- Missed Abortion, Anembryonic Pregnancy, Non-Viable Pregnancy
- Trial name
- NCT05216952
- Testing
- Ulipristal Acetate Tablets, Misoprostol Pill
- Where
- 4 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of North Carolina, Chapel Hill
Repeated Spontaneous Miscarriages, Fetal Deaths in Utero
Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from…
- Trial name
- DEFI-2 (NCT04207814)
- Testing
- biological sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Recurrent Abortion
Histopathological Evaluation of Product of Conception in Sporadic and Recurrent Abortions
1. To evaluate histopathological findings of products of conception in both sporadic and recurrent miscarriage. 2. To determine the prevalence of chronic histiocytic intervillositis in both sporadic and recurrent miscarriage.
- Trial name
- NCT04326595
- Testing
- surgical and medical evacuation
- Volunteers
- 300 people
- Sponsor
- Assiut University
Cervical Incompetence
Prolene Versus Ethibond for Cervical Cerclage
The purpose of the proposed study is to examine the relationship between cerclage suture material of Ethibond and Prolene and its effect on the vaginal microbiome in a prospective randomized control trial.
- Trial name
- PECC (NCT03311867)
- Testing
- Ethibond Suture, Prolene Suture
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Recurrent Pregnancy Loss
Aspirin Versus Clopidogrel Effect on Uterine Blood Flow in Women With Unexplained Recurrent Miscarriages
The study will compare the effect of Aspirin versus clopidogrel effect on uterine perfusion in women with unexplained recurrent pregnancy loss with decreased uterine artery pulsatility index.
- Trial name
- NCT01635426
- Testing
- Aspirin, Clopidogrel
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Ain Shams University
Recurrent Miscarriage
Nutritional Deficiency and Recurrent Miscarriage
This prospective cohort study primarily aims to examine the association between blood niacin levels and recurrent miscarriage.
- Trial name
- NCT05267678
- Testing
- No intervention
- Where
- China
- Volunteers
- 499 people
- Sponsor
- Westlake University
Spontaneous Abortion, Malaria
Study of DDT and Loss of Clinically-Recognized Pregnancies in South Africa
Background: In some countries, such as South Africa, the pesticide DDT is an important chemical for control of malaria-carrying mosquitoes. However, there is little evidence about the effects that it might have on human health.
- Conditions
- Spontaneous Abortion, Malaria, Pregnancy Outcome, Stillbirth
- Trial name
- NCT00878098
- Where
- South Africa
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Recurrent Miscarriage
Effect of Prednisolone Treatment on Uterine Natural Killer Cells
This study aims to investigate the role of uNK cells and the association with prednisolone.
- Trial name
- NCT03902912
- Testing
- Prednisolone
- Where
- Hong Kong
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Abortion, Habitual
Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage
The definition of recurrent spontaneous abortion (RSA) has changed over the years, and most societies now advocate defining RSA as two or three consecutive or discontinuous miscarriages with the same sexual partner before 24…
- Trial name
- microRNA410 (NCT05658445)
- Testing
- evacuation
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Assiut University
Luteal Phase, Biomarkers
Early Pregnancy Cohort and Preimplantation Factor
Miscarriage is a common event associated with severe psychological and social morbidity, further tormenting in women suffering recurrent pregnancy loss (RPL) by at least three consecutive losses.
- Conditions
- Luteal Phase, Biomarkers, Abortion, Spontaneous, Abortion, Habitual
- Trial name
- PEP-cohort (NCT02761772)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Missed Abortion
Comparative Study Between Combined Vaginal Misoprostol
"Comparative study between Combined Vaginal Misoprostol with Isosorbide-5-Mononitrate
- Trial name
- comparative (NCT04981457)
- Testing
- Misoprostol and iso sorbide mononitrates
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Miscarriage, Recurrent
Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure
To compare the abv3-integrin expression in endometrium tissue among RIF women between the GnRH analogue with Aromatase Inhibitor (Group A) , GnRH analogue with progesterone (Group B) and GnRH analogue alone as control group…
- Trial name
- NCT05437471
- Testing
- GNRH Analoge, Duphaston, Letrozole
- Where
- Malaysia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre