Clinical trials: Spontaneous Abortions
Infertility and Miscarriage
A Multicenter, Prospective, Randomized Controlled Clinical Study on the Effect of Hysteroscopic Uterine Septum Resection on IVF-ET Outcomes in Infertile Patients With Non-recurrent Miscarriage
This study aims to evaluate the impact of hysteroscopic transcervical resection of the septum (TCRS) on fertility in infertile women without recurrent miscarriage, primarily assessing its effect on subsequent IVF-ET outcomes.
- Trial name
- NCT07611656
- Testing
- Transcervical resection of septum
- Where
- China
- Volunteers
- 236 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Pregnancy Complications, Pregnancy Outcome
BioThrax® (Anthrax) Vaccine in Pregnancy Registry
The purpose of this study is to determine if inadvertent receipt of the BioThrax vaccine during pregnancy is independently associated with adverse maternal, pregnancy, or infant health outcomes.
- Conditions
- Pregnancy Complications, Pregnancy Outcome, Congenital Abnormalities
- Trial name
- NCT01653392
- Testing
- Observational Intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Infertility, Recurrent Pregnancy Loss
Preimplantation Genetic Diagnosis Using Blastocyst Biopsy and Array CGH
The investigators propose to perform a clinical randomized trial to evaluate the effect of single embryo (blastocyst) transfer (SET) with array CGH for the evaluation of the complete chromosome complement of the blastocyst in…
- Trial name
- NCT01546350
- Testing
- PGD
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Reprogenetics
Retained Product of Conception After First Trimester Medical Abortion
Success Rates of Expectant vs. Medical Management for Retained Products After First-Trimester Abortion: Randomized Controlled Trial
This prospective randomized controlled trial evaluates the success of medical versus expectant management for retained products of conception (RPOC) following medical abortion with mifepristone and misoprostol for delayed…
- Trial name
- NCT07534982
- Testing
- medical management with misoprostol
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Yael Yagur
Miscarriage
Feasibility Study of a Coping Intervention for Recurrent Miscarriage
Some women experience the pain of miscarriage on numerous occasions. Studies show that these women experience feelings of anxiety and distress during the early stages of a new pregnancy as they worry another miscarriage will…
- Trial name
- NCT02989220
- Testing
- Positive Reappraisal Coping Intervention
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Abortion, Spontaneous, Abortion, Habitual
Intralipid for Recurrent Miscarriage
Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.
- Trial name
- NCT01788540
- Testing
- Intralipid
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Early Pregnancy Loss, Procedural Pain, Anxiety
Virtual Reality for Pain and Anxiety During Surgical Uterine Evacuation After Early Pregnancy Loss
This study will examine whether virtual reality can reduce pain and anxiety in women undergoing surgical uterine evacuation after early pregnancy loss at Tarsus State Hospital, Türkiye.
- Trial name
- NCT07907679
- Testing
- Virtual Reality Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Tarsus University
Recurrent Miscarriage
3D Ultrasound to Assess in Recurrent Miscarriage
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
- Trial name
- 3D-ARM (NCT06164015)
- Testing
- 3D Ultrasound scan with power Doppler angiography
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Incomplete Abortion
Misoprostol Treatment of Mid Trimester Incomplete Abortion by Midwives and Doctors in Uganda.
It is estimated that 47,000 women die every year due to consequences of unsafe abortion globally. The majority of pregnancy related deaths occur in low income countries where induced abortion is restricted, unmet need for…
- Trial name
- NCT03622073
- Testing
- Misoprostol treatment by Midwife, Misoprostol treatment by Doctor
- Where
- 14 sites in Uganda
- Volunteers
- 1,191 people
- Sponsor
- Makerere University
Birth Defect, Spontaneous Abortions
Nplate® Pregnancy Exposure Registry
US study to estimate the prevalence at birth of major birth defects (ie, those that cause significant functional or cosmetic impairment, require surgery, or are life-limiting) in children born to mothers who have received Nplate®…
- Conditions
- Birth Defect, Spontaneous Abortions, Low Birth Weight
- Trial name
- NPER (NCT02090088)
- Testing
- Not applicable- observational study
- Volunteers
- 4 people
- Sponsor
- Amgen
Termination of Pregnancy, Covid19
Impact of COVID-19 Pandemic on Early Spontaneous Abortions and Early Termination of Pregnancy
To see the impact the COVID-19 pandemic has had on early spontaneous abortions and early termination of pregnancy in the first trimester
- Conditions
- Termination of Pregnancy, Covid19, Pregnancy Loss
- Trial name
- NCT04910958
- Where
- Israel
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Abortion Threatened
Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage
Threatened miscarriage occurs in about one-fifth of pregnancies with an estimated miscarriage rate of 3-16% after successful demonstration of fetal cardiac activity.
- Trial name
- NCT03797508
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Threatened Miscarriage, Early Pregnancy Bleeding
Comparison of Dydrogesterone Alone Versus Dydrogesterone Plus HCG in Threatened Miscarriage
This randomized controlled trial aims to compare the efficacy of Dydrogesterone alone versus Dydrogesterone combined with human chorionic gonadotrophin (HCG) in the treatment of threatened miscarriage in first trimester…
- Trial name
- DYD-HCG (NCT07608133)
- Testing
- Dydrogesterone, Human chorionic gonadotrophin (hCG)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Pregnancy Early, Miscarriage
Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders
Gonadotropin Releasing Hormone agonist (GnRHa) triggering is used as an alternative to human chorionic gonadotropin (hCG) in GnRH antagonist protocol to eliminate the risk of ovarian hyperstimulation syndrome (OHSS).
- Conditions
- Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome
- Trial name
- NCT04797338
- Testing
- Synarel, 0.2 Mg/Inh Nasal Spray, Estrofem, Utrogestan
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Recurrent Spontaneous Abortion
Difference Between Mean Gestational Sac Diameter and Crown-rump Length as a Marker of First-trimester Pregnancy Outcome in Patients With Recurrent Spontaneous Abortion
Objective: To determine the effect and predictive value of the difference between the mean gestational diameter (mGSD) sac and crown-rump length (CRL) of the first trimester on the pregnancy outcomes of patients with recurrent…
- Trial name
- mGSD-CRL& RSA (NCT06081556)
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Pregnancy of Unknown Location
Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location
Infertility patients have a higher baseline risk of ectopic pregnancy compared to the general population. If an early pregnancy is not visible by ultrasound, patients with a pregnancy of unknown location (PUL) will undergo…
- Trial name
- NCT07469605
- Testing
- Hysteroscopy for diagnosis and treatment of pregnancy of unknown location
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Recurrent Pregnancy Loss
Association of HY-restricting HLA Class II Alleles, Sex of Firstborn Child, and Pregnancy Outcome in RPL Patients
This cross-sectional and prospective cohort study will investigate if sRPL patients with a first born boy who carry ≥1 HY-restricting (HY-r) HLA class II alleles are associated with a lower chance for a succesful reproductive…
- Trial name
- NCT05342948
- Where
- Denmark
- Volunteers
- 583 people
- Sponsor
- Aalborg University Hospital
Endometriosis, Pregnancy Complications
Impact of Endometriosis on Pregnancy and Delivery - a Retrospective Cohort Study
Purpose: To study the impact of endometriosis on subsequent pregnancy and delivery. Methods: retrospective analysis by questionnaire / interview of cases (endometriosis laparoscopically removed / child wish) vs.
- Conditions
- Endometriosis, Pregnancy Complications, Delivery Complication, Complication
- Trial name
- NCT04664335
- Testing
- questionnaire
- Where
- Germany
- Volunteers
- 1,762 people
- Sponsor
- University Hospital Muenster
Beta-hCG Positivity, Clinical Pregnancy
Evaluation of Assisted Reproductive Technology (ART) Outcomes in Couples With Nonobstructive Azoospermia, Cryptozoospermia, and Severe Oligozoospermia
This study aims to compare the In Vitro Fertilization (IVF/ICSI) outcomes of patients with a sperm concentration of <5 million/mL (severe oligozoospermia) and <1 million/mL (cryptozoospermia) to those diagnosed with…
- Conditions
- Beta-hCG Positivity, Clinical Pregnancy, Miscarriage, Multiple Pregnancy
- Trial name
- ART (NCT07897279)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Vaginosis, Bacterial, Abortion, Spontaneous
Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery
To determine whether screening of pregnant women with history of previous preterm delivery or with premature contractions for bacterial vaginosis using VS-SENSE, and treatment of positive women will reduce the risk of spontaneous…
- Conditions
- Vaginosis, Bacterial, Abortion, Spontaneous, Premature Birth
- Trial name
- NCT00491270
- Testing
- VS Sense
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya