Clinical trials: Spontaneous Bacterial Peritonitis
SBP - Spontaneous Bacterial Peritonitis
N-Acetylcysteine in the Management of Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is one of the most serious infectious complications of liver cirrhosis and ascites. It affects approximately 10-30% of hospitalized patients with decompensated cirrhosis and carries an…
- Trial name
- NCT07803952
- Testing
- NAC
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
SBP - Spontaneous Bacterial Peritonitis
Nitazoxanide in Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of liver cirrhosis characterized by infection of ascitic fluid in the absence of an evident intra-abdominal source.
- Trial name
- NCT07808450
- Testing
- Nitazoxanide (NTZ)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Cirrhosis, Hepatic Encephalopathy
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis
The study aims to compare the potential benefit of allopurinol versus atorvastatin in reducing the risk of developing cirrhosis-related complications, delaying the onset of hepatocellular carcinoma, and improving survival.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Ascites, Varices
- Trial name
- NCT05511766
- Testing
- Allopurinol 300 MG, Atorvastatin 20mg
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Cirrhosis With Spontaneous Bacterial Peritonitis
Clinical Study on the Effectiveness of Antibiotics Combined With Bifidobacterium Quadruple Live Tablets in Treating Cirrhosis With Spontaneous Bacterial Peritonitis and Preventing Recurrence
This is a prospective, randomized, double-blind, placebo-controlled multicenter clinical study targeting cirrhosis patients with Spontaneous Bacterial Peritonitis(SBP), aiming to evaluate whether adding Bifidobacterium quadruple…
- Trial name
- NCT07686861
- Testing
- Bifidobacterium quadruple live tablets
- Where
- 30 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University First Hospital
Cirrhosis, Spontaneous Bacterial Peritonitis
Doxycycline for the Prevention of Spontaneous Bacterial Peritonitis
The utilization of doxycycline for SBP prophylaxis is a novel practice at MDMC. Therefore, an assessment of safety and efficacy is needed in order to generalize this practice.
- Trial name
- NCT04153604
- Testing
- doxycycline
- Where
- United States
- Volunteers
- 841 people
- Sponsor
- Methodist Health System
Spontaneous Bacterial Peritonitis
Predicting and Monitoring Spontaneous Bacterial Peritonitis in Cirrhotic Patients Using the Mansoura Scoring System
The aim of this prospective study was to examine predictors of SBP in order to develop a noninvasive method to identify or exclude an episode of SBP, for starting early treatment with antibiotics, so decrease morbidity and…
- Trial name
- MaSS/SBP (NCT07024355)
- Volunteers
- 250 people
- Sponsor
- Assiut University
Spontaneous Bacterial Peritonitis
Prediction of SBP in Cirrhotic Patients by Platlet Count, Na and AlBl Index.
This study aims to evaluate whether integrating serum sodium levels and platelet count with the Albumin-Bilirubin (ALBI) score can improve the early prediction of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with…
- Trial name
- NCT07116369
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Spontaneous Bacterial Peritonitis, Cirrhoses, Liver
Comparative Study of Secondary Prophylaxis for SBP
The goal of this clinical trial is to learn if norfloxacin, nitazoxanide, and colistin work as secondary prophylactic agents for spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites.
- Conditions
- Spontaneous Bacterial Peritonitis, Cirrhoses, Liver, Ascites
- Trial name
- 3C-SPS (NCT06827756)
- Testing
- Norfloxacin 400 MG, Nitazoxanide 500 MG, Colistin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis
Frequency and Predictors of Recurrent SBP in Cirrhotic Patients in Al Rajhi University Hospital
Assess the frequency of recurrent SBP in ascitic cirrhotic patients. Determine the predictive factors of recurrence after the first episode of SBP in ascitic cirrhotic patients
- Trial name
- NCT06778616
- Where
- 2 sites in Egypt
- Volunteers
- 101 people
- Sponsor
- Assiut University
Cirrhosis, Spontaneous Bacterial Peritonitis
Early Ascitis Parencentesis in SBP
Paracentesis at 48 hours, as recommended in international guidelines, could delay the time to effective antibiotic therapy in cases of SBP with germs resistant to empirical antibiotic therapy.
- Trial name
- PAPISLA (NCT06679842)
- Testing
- ascitis paracentesis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Liver Cirrhosis, Spontaneous Bacterial Peritonitis
Efficacy of Conventional Dose Protocol vs Low Dose Protocol Albumin Use in Patients With Cirrhosis and High Risk Spontaneous Bacterial Peritonitis
The role of Albumin in prevention and Treatment of Acute Kidney Injury (AKI) in patients with Spontaneous Bacterial Peritonitis (SBP) who are at high risk of AKI development has been clearly defined, which decreases the morbidity…
- Trial name
- NCT06026267
- Testing
- 20% High Dose Albumin, Standard Medical Treatment, 20% Reduced Dose Albumin
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Spontaneous Bacterial Peritonitis
Rifaximin as a Prophylaxis of Spontaneous Bacterial Peritonitis in Comparison With Ciprofloxacin
The goal of this Randomized controlled trial is to assessment the efficacy of Rifaximin as a prophylaxis of SBP in comparison with ciprofloxacin in Egyptian patients.
- Trial name
- NCT06234046
- Testing
- Rifaximin 550Mg Tab, Ciprofloxacin 750 MG, ascitic fluid sample
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Spontaneous Bacterial Peritonitis
Efficacy of Rifaximin vs Norfloxacin for Secondary Prophylaxis of SBP (NORRIF Trial)
SBP is a common complication of cirrhotics with associated increased mortality. After first episode of SBP there is increased risk of again developing SBP, with increased chance of developing resistant organism.
- Trial name
- NCT06199843
- Testing
- Rifaximin, Norfloxacin
- Where
- India
- Volunteers
- 280 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Spontaneous Bacterial Peritonitis
Primary Antibiotic Prophylaxis Using Co-trimoxazole to Prevent Spontaneous Bacterial Peritonitis in Cirrhosis
A multicentre, interventional, double-blind, placebo-controlled, parallel-arm, phase 3, randomised controlled trial to evaluate the use of co-trimoxazole as primary prophylaxis for spontaneous bacterial peritonitis to improve…
- Trial name
- ASEPTIC (NCT04395365)
- Testing
- Co-Trimoxazole 960Mg Dispersible Tablet
- Where
- United Kingdom
- Volunteers
- 442 people
- Sponsor
- University College, London
Cirrhotic Patients With Spontaneous Bacterial Peritonitis
Platelets to Lymphocytes Ratio and Monocytes to Lymphocytes Ratio as Predictors of Response to Treatment in Cirrhotic Patients With Spontaneous Bacterial Peritonitis.
Spontaneous bacterial peritonitis (SBP) is a serious complication of ascites that can lead to death and can be described as an acute infection of ascites without any certain source of infection SBP is considered the most common…
- Trial name
- NCT05850858
- Testing
- ascetic fluid study
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Sohag University
Spontaneous Bacterial Peritonitis
Laboratory Diagnosis of Spontaneous Bacterial Peritonitis
This study aims at evaluating the diagnostic accuracy of serum procalcitonin, PEC index, modified Wehmeyer, and Mansoura scoring systems for SBP in cirrhotic patients with ascites
- Trial name
- SBP (NCT05696054)
- Volunteers
- 80 people
- Sponsor
- Sohag University
Spontaneous Bacterial Peritonitis
MPV and NLR as Predictors of SBP Diagnosis
The aim of the study is to investigate the clinical utility of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as diagnostic markers for spontaneous bacterial peritonitis (SBP).
- Trial name
- NCT04775420
- Testing
- Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)
- Where
- Egypt
- Volunteers
- 332 people
- Sponsor
- Sohag University
Spontaneous Bacterial Peritonitis
Ascitic Fluid Calprotectin as an Accurate Diagnostic Marker for Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is an infection of the ascitic fluid in patients with liver cirrhosis and portal hypertension.
- Trial name
- NCT05422118
- Testing
- ascitic fluid calprotectin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Spontaneous Bacterial Peritonitis
Meropenem vs Cefotaxime as Empirical Treatment of SBP
We aimed to evaluate whether meropenem is superior to cefotaxime for treatment of SBP empirically.
- Trial name
- NCT05427747
- Testing
- cefotaxime
- Volunteers
- 286 people
- Sponsor
- Assiut University
Spontaneous Bacterial Peritonitis
Serum Copeptin in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
Current reports have demonstrated that copeptin predicts disease progression and prognosis in cirrhotic patients, independent of liver-specific scoring systems.
- Trial name
- NCT05401721
- Testing
- Serum copeptin
- Where
- Egypt
- Volunteers
- 89 people
- Sponsor
- Sohag University