Clinical trials: Spontaneous Bacterial Peritonitis
Peritonitis Bacterial, Liver Cirrhosis
Meropenem Pharmacokinetics in Spontaneous Bacterial Peritonitis
The emergence of multidrug-resistant bacteria has increased the use of meropenem in spontaneous bacterial peritonitis (SBP). Additionally, recent studies suggested female gender as an independent risk factor for mortality in SBP.
- Trial name
- NCT03571711
- Testing
- Meropenem Injection
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Hannover Medical School
Peritonitis, Catheter-related Infections
Taurolock for Preventing Bacterial Peritonitis During Renal Insufficiency
Dialysis catheters are sites of bacterial proliferation. The purpose of this study is to determine whether or not the use of Taurolock (a catheter lock solution) can prevent bacterial peritonitis in patients undergoing peritoneal…
- Conditions
- Peritonitis, Catheter-related Infections, Renal Insufficiency
- Trial name
- NCT01101087
- Testing
- Taurolock
- Where
- 15 sites in France, French Polynesia
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Spontaneous Bacterial Peritonitis
Ascitic Fluid Calprotectin as an Accurate Diagnostic Marker for Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is an infection of the ascitic fluid in patients with liver cirrhosis and portal hypertension.
- Trial name
- NCT05422118
- Testing
- ascitic fluid calprotectin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Liver Cirrhosis, Spontaneous Bacterial Peritonitis
Efficacy of Conventional Dose Protocol vs Low Dose Protocol Albumin Use in Patients With Cirrhosis and High Risk Spontaneous Bacterial Peritonitis
The role of Albumin in prevention and Treatment of Acute Kidney Injury (AKI) in patients with Spontaneous Bacterial Peritonitis (SBP) who are at high risk of AKI development has been clearly defined, which decreases the morbidity…
- Trial name
- NCT06026267
- Testing
- 20% High Dose Albumin, Standard Medical Treatment, 20% Reduced Dose Albumin
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Spontaneous Bacterial Peritonitis, Ascites
Comparative Study of Rifaximin Versus Norfloxacin in the Secondary Prophylaxis of Spontaneous Bacterial Peritonitis
The aim of the study is to compare the effectiveness of rifaximin versus norfloxacin for secondary prevention of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites.
- Conditions
- Spontaneous Bacterial Peritonitis, Ascites, Liver Cirrhosis
- Trial name
- SBP (NCT02120196)
- Testing
- Rifaximin, Norfloxacin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sherief Abd-Elsalam
Liver Cirrhosis, Upper Gastrointestinal Bleeding
Prophylactic Antibiotics in Prevention of Spontaneous Bacterial Peritonitis in Compensated Liver Cirrhosis
timely short-term antibiotic prophylaxis is an essential step in the management of these patients . Prophylaxis must be instituted as early as variceal hemorrhage is suspected, and timely administration has been associated with a…
- Trial name
- NCT04711122
- Testing
- Third generation cephalosporin antibiotics
- Volunteers
- 80 people
- Sponsor
- Assiut University
Liver Cirrhosis
Evaluation of Lactoferrin, Procalcitonin and Aution® Urine Dipsticks for the Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients
Bacterial infections are a major cause of mortality in cirrhotic patients in the context of gastrointestinal bleeding or spontaneous bacterial peritonitis (SBP).
- Trial name
- NCT02798939
- Where
- France
- Volunteers
- 123 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Spontaneous Bacterial Peritonitis
Nitazoxanide in Prevention of Secondary Spontaneous Peritonitis
the study is to evaluate the possible efficacy and safety of nitazoxanide as an adjuvant therapy in the secondary prevention of SBP in patient with cirrhosis.
- Trial name
- NCT04746937
- Testing
- Nitazoxanide, Norfloxacin
- Volunteers
- 60 people
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis
Rifaximin as a Prophylaxis of Spontaneous Bacterial Peritonitis in Comparison With Ciprofloxacin
The goal of this Randomized controlled trial is to assessment the efficacy of Rifaximin as a prophylaxis of SBP in comparison with ciprofloxacin in Egyptian patients.
- Trial name
- NCT06234046
- Testing
- Rifaximin 550Mg Tab, Ciprofloxacin 750 MG, ascitic fluid sample
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cirrhosis
Intravenous Ciprofloxacin Versus Intravenous Ceftriaxone: Spontaneous Bacterial Peritonitis in Cirrhosis of Liver
Spontaneous bacterial peritonitis (SBP) is one of the leading causes of morbidity and mortality in patients with cirrhosis. Spontaneous bacterial peritonitis (SBP) is a common bacterial infection in patients with cirrhosis and…
- Trial name
- NCT07552870
- Testing
- intravenous ciprofloxacin, intravenous ceftriaxone
- Where
- Pakistan
- Volunteers
- 310 people
- Sponsor
- Shahida Islam Medical Complex
Renal Impairment, All Cause Mortality
Low-dose Albumin Solution in SBP: a Randomized Double-blind Pilot Study
Spontaneous bacterial peritonitis (SBP) is a common and severe complication of cirrhosis. The most serious complication of SBP is the hepatorenal syndrome (HRS), which occurs in up to 30 percent of patients, with high mortality.
- Trial name
- ALTERNATE (NCT00852800)
- Testing
- Albumin
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cirrhosis, Spontaneous Bacterial Peritonitis
Doxycycline for the Prevention of Spontaneous Bacterial Peritonitis
The utilization of doxycycline for SBP prophylaxis is a novel practice at MDMC. Therefore, an assessment of safety and efficacy is needed in order to generalize this practice.
- Trial name
- NCT04153604
- Testing
- doxycycline
- Where
- United States
- Volunteers
- 841 people
- Sponsor
- Methodist Health System
Cirrhosis, Liver
Platelet Indices Could Predict Spontaneous Bacterial Peritonitis in Cirrhotic Ascitic Patients
Spontaneous bacterial peritonitis (SBP) is an ascitic fluid infection in cirrhotic patients
- Trial name
- NCT03172013
- Testing
- Platelet indices
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis
Rifaximin Versus Norfloxacin in Spontaneous Bacterial Peritonitis
Background Prophylaxis of SBP is indicated in three high-risk populations: patients with acute gastrointestinal hemorrhage, patients with low total protein content in ascitic fluid, and patients with a previous history of SBP…
- Trial name
- NCT04159870
- Testing
- Rifaximin, Norfloxacin
- Where
- Italy
- Volunteers
- 322 people
- Sponsor
- Ospedali Riuniti di Foggia
Cirrhotic Patients With Spontaneous Bacterial Peritonitis
Platelets to Lymphocytes Ratio and Monocytes to Lymphocytes Ratio as Predictors of Response to Treatment in Cirrhotic Patients With Spontaneous Bacterial Peritonitis.
Spontaneous bacterial peritonitis (SBP) is a serious complication of ascites that can lead to death and can be described as an acute infection of ascites without any certain source of infection SBP is considered the most common…
- Trial name
- NCT05850858
- Testing
- ascetic fluid study
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Sohag University
Cirrhosis, Sepsis
Albumin Administration in Cirrhotic Patients With Bacterial Infection and a Systemic Inflammatory Response Syndrome Unrelated to Spontaneous Bacterial Peritonitis
Patients with cirrhosis present an increased susceptibility to bacterial infections. Spontaneous bacterial peritonitis (SBP) is the most frequent infection and induces severe circulatory dysfunction associated with renal failure…
- Conditions
- Cirrhosis, Sepsis, Renal Failure
- Trial name
- ALB-CIRINF (NCT01359813)
- Testing
- Human Albumin
- Where
- 35 sites in France
- Volunteers
- 193 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cirrhosis, Spontaneous Bacterial Peritonitis
Early Ascitis Parencentesis in SBP
Paracentesis at 48 hours, as recommended in international guidelines, could delay the time to effective antibiotic therapy in cases of SBP with germs resistant to empirical antibiotic therapy.
- Trial name
- PAPISLA (NCT06679842)
- Testing
- ascitis paracentesis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Primary Bacterial Peritonitis
Identification of Ascitic Fluid Bacterial Pathogens in Spontaneous Bacterial Peritonitis
Several studies have pointed out changes in the epidemiology of the causative bacteria in SBP and bacterascites and in their susceptibility to antibiotics.
- Trial name
- NCT02463721
- Testing
- ascitic fluid culture and microbiological testing
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
SBP, Liver Cirrhosis
Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of SBP in Patients With LC
Spontaneous bacterial peritonitis (SBP) is one of the most serious complications of liver cirrhosis. Mainstay of treatment for SBP is use of proper antibiotics.
- Trial name
- NCT01265173
- Testing
- Cefotaxime, Ceftriaxone, Ciprofloxacin
- Where
- 2 sites in South Korea
- Volunteers
- 261 people
- Sponsor
- Korea University
Rapid Diagnosis of Spontaneous Infection of Ascitic Fluid
Calprotectin for Rapid Diagnostic Infection Spontaneous of Ascites
The prognosis of spontaneous bacterial peritonitis (ISLA) remains a serious complication of cirrhosis. Rapid diagnosis of ISLA is a key issue for improving the prognosis.
- Trial name
- Ca-DRISLA (NCT02857101)
- Testing
- dosage of calprotectin
- Where
- France
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon