Clinical trials: Spontaneous Breathing Trial
Mechanically Ventilated Patients, Extubation
Weaning And Variability Evaluation
Knowing when to liberate patients from mechanical ventilation (i.e. removal of breathing or endotracheal tube or extubation) is critically important, as both prolonged ventilation and failed extubation are both associated with…
- Trial name
- WAVE (NCT01237886)
- Where
- 14 sites in United States, Canada
- Volunteers
- 660 people
- Sponsor
- Ottawa Hospital Research Institute
Heart Transplant
Non-Intubated Anesthesia for Adult Heart Transplantation
This prospective, multicenter, randomized controlled trial aims to evaluate whether non-intubated spontaneous ventilation anesthesia (NISVA) supported by a supraglottic airway can reduce cardiopulmonary complications and promote…
- Trial name
- NISVA-HTx (NCT07758894)
- Testing
- Non-Intubated Spontaneous Ventilation Anesthesia, Conventional Anesthesia, Standardized Perioperative Anesthetic and Analgesic Medication Regimen
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Respiratory Failure
Impact of Respiratory Muscle Unloading on Respiratory Muscle Endurance
This study investigates how different degrees of muscular unloading during mechanical ventilation impact endurance of succeeding spontaneous breathing trials
- Trial name
- NCT00415896
- Testing
- positive pressure ventilation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Krankenhaus Kloster Grafschaft
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Critically Ill
Microcirculation in Spontaneous Breathing Trial
Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients.
- Trial name
- NCT04711590
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation Weaning From Mechanical Ventilation Extubation Failure Critical Illness
Delta Pocc During Spontaneous Breathing Trial to Predict Extubation Failure in Mechanically Ventilated Adults (DELTA-EXT)
This prospective observational single-center study will evaluate whether dynamic respiratory stress estimated by delta airway occlusion pressure deflection (Delta Pocc) during a standardized spontaneous breathing trial can…
- Trial name
- DELTA-EXT (NCT07634783)
- Testing
- Delta Pocc Measurement During Spontaneous Breathing Trial
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Sanatorio Parque, Argentina
Critical Care, Oxygen Therapy
Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials
Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory…
- Conditions
- Critical Care, Oxygen Therapy, Mechanical Ventilation
- Trial name
- NCT06816706
- Testing
- Modified high flow tracheal oxygen-40L/min, Standard high flow tracheal oxygen-40L/min, T-piece
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jian-Xin Zhou
Electromyography, Ventilator Weaning
Analysis on the Fatigue and Electromyographic Activation on the Mechanical Ventilation Weaning
This study aims to evaluate respiratory muscle activation and fatigue during the mechanical ventilation weaning process using surface electromyography (sEMG).
- Conditions
- Electromyography, Ventilator Weaning, Critical Illness, Intensive Care
- Trial name
- AFAEMG (NCT07387731)
- Testing
- Sponteneous breathing test in T-tube, Sponteneous breathing test in suport ventilation (PSV)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Weaning Mechanical Ventilation
Airway Occlusion Pressure Derived Parameters During Spotaneous Breathing Trial for Predicting Extubation Failure
Weaning from invasive mechanical ventilation (IMV) is a critical stage of the intensive care unit (ICU) stay. Premature IMV discontinuation may expose patients to substantial cardiopulmonary stress, whereas prolonged weaning…
- Trial name
- Weaning-POP (NCT07786519)
- Where
- 4 sites in France
- Volunteers
- 225 people
- Sponsor
- Rennes University Hospital
Pulmonary Nodules, Lung Neoplasms
Non-intubated Versus Intubated Anesthesia for Thoracoscopic Sublobar Resection
This is a large clinical study that compares two different types of anesthesia for patients undergoing a specific kind of minimally invasive lung surgery (thoracoscopic sublobar resection) to remove small, early-stage lung…
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Thoracic Surgery
- Trial name
- NIVA-TSLR (NCT07395375)
- Testing
- Non-intubated Anesthesia, Conventional Intubated General Anesthesia, Laryngeal Mask Airway (LMA)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Respiratory Failure
Extubation With or Without Spontaneous Breathing Trial
Spontaneous breathing trial (SBT) has long been thought to be a essential process before extubation. In this study,the investigator hypothesized that SBT could be not essential during weaning from ventilator and investigated…
- Trial name
- SBT (NCT01020773)
- Testing
- spontaneous breathing trial
- Volunteers
- 67 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Critically Ill
Frequency of Screening and SBT Technique Trial
The requirement for invasive mechanical ventilation is a defining feature of critical illness. Liberation or weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Trial name
- FAST (NCT02399267)
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Difficult Mechanical Ventilation Weaning, Spontaneous Breathing Trial
Non-medicinal Technique and Dyspnea in Weaning Patients
This is a randomized, controlled, multicenter, open-label, category 2, parallel-arm study of efficacy and superiority. The target population are patients hospitalized in the intensive care unit (ICU), ventilated with invasive…
- Conditions
- Difficult Mechanical Ventilation Weaning, Spontaneous Breathing Trial, Dyspnea
- Trial name
- Easy Wean (NCT06926231)
- Testing
- Protocolized medical hypnosis, Protocolized standard of care
- Where
- 5 sites in France
- Volunteers
- 82 people
- Sponsor
- Hospices Civils de Lyon
Respiration, Artificial, Ventilator Weaning
Pressure Support Reduction Versus Spontaneous Breathing Trials in Weaning From Ventilation
This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.
- Trial name
- NCT00911378
- Testing
- Pressure support ventilation, Spontaneous breathing trials
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Respiratory Distress Syndrome
Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients
This is a single-center, prospective, randomized, three-period crossover physiological study in adult patients with moderate-to-severe acute respiratory distress syndrome (ARDS, PaO₂/FiO₂ ≤150 mmHg).
- Trial name
- SBA-APRV (NCT07798154)
- Testing
- APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critical Illness, Intensive Care Units (ICUs)
Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit
The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing…
- Conditions
- Critical Illness, Intensive Care Units (ICUs), Weaning Failure, Mechanical Ventilation
- Trial name
- SERA-Effort (NCT07109570)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Critically Ill
The Frequency of Screening and SBT Technique Trial: The FAST Trial
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing.
- Trial name
- NCT02969226
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 17 sites in United States, Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure
Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure may progress to acute respiratory distress syndrome, a life-threatening condition that often requires mechanical ventilation.
- Trial name
- SVALBARD (NCT07463885)
- Testing
- Spontaneous Ventilation Strategy, Controlled Ventilation Strategy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Patient Ventilator Interactions, Spontaneous Breathing Trial
Entropy Analysis and Complex Patient-ventilator Interactions During Mechanical Ventilation
Complex patterns of patient-ventilator interactions could be miscalculated by visual observation of mechanical ventilator screens or current algorithms based on physiologic waveforms to detect patient-ventilator asynchronies.
- Trial name
- ENTROPY-ICU (NCT04128124)
- Testing
- processing signals of airway pressure and airway flow to calculate entropy
- Where
- Spain
- Volunteers
- 107 people
- Sponsor
- Corporacion Parc Tauli
Anesthesia
Preoxygenation With Positive Inspiratory Pressure During Induction of Anesthesia
Adults patients scheduled for elective surgery were randomly allocated to receive preoxygenation with spontaneous breathing, positive pressure ventilation (positive inspiratory pressure: 12 cmH2O) without PEEP, and with PEEP…
- Trial name
- PREOX (NCT02313766)
- Testing
- PPV : positive pressure ventilation, PEEP : PPV + PEEP
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen