Clinical trials: Spontaneous Intracerebral Hemorrhage
Intracerebral Hemorrhage
Efficacy and Safety of Factor VIIa on Rebleeding After Surgery for Spontaneous Intracerebral Hemorrhage (ICH)
Although the role of surgical treatment is still controversial, surgical evacuation of intracerebral hematoma is a frequent practice. Rebleeding is a frequent complication in patients submitted to hematoma evacuation.
- Trial name
- PRE-SICH (NCT00128050)
- Testing
- rFactor VIIa (Eptacog alfa, NovoNordisk), rFVIIa, Sodiun chloride 0.9%
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment
China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）
Background: Although emergency surgery may reduce mortality in patients with severe spontaneous intracerebral hemorrhage (SSICH), the effectiveness and safety of surgical treatment among SSICH patients receiving long-term oral…
- Conditions
- Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment, Emergency Surgery, Complications
- Trial name
- NCT05975398
- Testing
- Emergency neurosurgery, Conservative treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Spontaneous Intracerebral Hemorrhage
Stromal Vascular Fraction (SVF) Therapy in Patients With Acute Spontaneous Intracerebral Hemorrhage (SICH).
The purpose of this pilot study is to evaluate the safety of stromal vascular fraction (SVF) therapy in patients with spontaneous intracerebral hemorrhage (SICH).
- Trial name
- NCT05232903
- Testing
- SVF therapy group
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
REmifentanil And Dexmedetomidine for EarlY Intensive Blood Pressure Lowering in ICH.
Intracerebral hemorrhage (ICH) remains the most devastating subtype of stroke, with a case fatality rate of approximately 40% at one months post-onset, imposing a particularly heavy medical and economic burden on low- and…
- Trial name
- READY-ICH (NCT07695220)
- Testing
- Remifentanil and Dexmedetomidine, Guideline standard care
- Volunteers
- 1,116 people
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Intracerebral Haemorrhage, Intracerebral Haemorrhage, Intraventricular
Prehospital and Acute Phase Characteristics of Severe Spontaneous ICH
Spontaneous intracerebral hemorrhage (ICH) represents 10-15% of all strokes and is associated with high mortality and morbidity. Rapid identification and interventions, e.g.
- Conditions
- Intracerebral Haemorrhage, Intracerebral Haemorrhage, Intraventricular, ICH - Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage
- Trial name
- NCT07739030
- Where
- Denmark
- Volunteers
- 678 people
- Sponsor
- Kirsten Moller
Intracerebral Hemorrhage
Non-invasive Evaluation of Cerebrovascular Reactivity in Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) remains a significant cause of morbidity and mortality around the globe. The most common etiology of nontraumatic spontaneous ICH is hypertensive arteriopathy (HA), while cerebral…
- Trial name
- NCT03815513
- Testing
- brain MRI
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spontaneous Intracerebral Hemorrhage
Etiology and Prognosis of sICH Based on Hemorrhage Location
The investigators retrospectively collected participants with spontaneous cerebral hemorrhage(sICH) from January 2015 to December 2019 for training and internal validation. Clinical and imaging data were collected.
- Trial name
- NCT06498778
- Where
- China
- Volunteers
- 698 people
- Sponsor
- Jinling Hospital, China
Spontaneous Intracranial Hemorrhage, Spontaneous Intraparenchymal Cerebral Hemorrhage
The Influencing Factors and Prediction Model of Poor Prognosis of Spontaneous Intraparenchymal Hemorrhage
This study was designed to explore the influencing factors of spontaneous intraparenchymal hemorrhage's prognosis and develop predictive models for poor prognosis by establishing a cohort of spontaneous intraparenchymal…
- Conditions
- Spontaneous Intracranial Hemorrhage, Spontaneous Intraparenchymal Cerebral Hemorrhage, Spontaneous Cerebellar Haemorrhage
- Trial name
- NCT03899350
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tang-Du Hospital
Intracerebral Hemorrhage, Cerebral Hemorrhage
MIECH: The Minimally Invasive Endoscopic Surgery With the Axonpen System for Spontaneous Intracerebral Hemorrhage
The primary objective of this trial is to provide preliminary safety data of minimally invasive endoscopic surgery using the Axonpen™ system for spontaneous intracerebral hemorrhage (ICH).
- Conditions
- Intracerebral Hemorrhage, Cerebral Hemorrhage, Intracranial Hemorrhage, Basal Ganglia Hemorrhage
- Trial name
- NCT04839770
- Testing
- Axonpen system
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Clearmind Biomedical Inc.
Spontaneous Intracerebral Hemorrhage, Hematoma Expansion
Noncontrast CT-Based Deep Learning for Predicting Hematoma Expansion Risk in Patients with Spontaneous Intracerebral Hemorrhage
Hematoma expansion is an independent predictor of poor prognosis and early neurological deterioration in patients with spontaneous intracerebral hemorrhage.
- Trial name
- NCCT-DL-HE (NCT06602115)
- Testing
- Observational study, no interventions involved
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Qiang Yu
Intracerebral Hemorrhage
Interventional Study for Detection of Prognosis of Blood Based Biomarkers in Intracerebral Hemorrhage
Explore blood based biomarkers in patients with intracerebral haemorrhage [cbc. Pt. LDH.CRP. Cholesterol. Na. K.. Mg. Urea Ca. Uric acid]
- Trial name
- NCT06745037
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Assiut University
Intracerebral Hemorrhage, Nontraumatic Intracerebral Hemorrhage
Detection of an Endovascular Treatment Target in Patients With an Acute, Spontaneous Intracerebral Hemorrhage
This study is to determine if a treatment target for a potential endovascular therapy exists in patients with an acute, spontaneous (non-traumatic) ICH.
- Trial name
- HemEXPLO (NCT05504941)
- Testing
- Diagnostic, cerebral Digital Subtraction Angiography (DSA)
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University Hospital, Basel, Switzerland
Treatment of Spontaneous Intracerebral Hemorrhage
Safety and Efficacy of Stereotactic Aspiration Plus Urokinase in Deep Intracerebral Hemorrhage Evacuation
This is a nationwide, multicenter, open-label, randomized controlled trial of early minimally invasive treatment for deep-seated spontaneous cerebral hemorrhage (dICH).
- Trial name
- STAPLE-dICH (NCT04686877)
- Testing
- STAPLE
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Intracerebral Hemorrhage Lobar
Neuronavigation-assisted Stereotactic Minimally Invasive Puncture With Tenecteplase for Acute Lobar Intracerebral Hemorrhage
Introduction: Minimally invasive puncture surgery with thrombolysis is effective for hypertensive intracerebral hemorrhage, but its effect on neurological recovery remains uncertain.
- Trial name
- NALICE-TNK (NCT07471256)
- Testing
- Neuronavigation-assisted Stereotactic Minimally Invasive Puncture Combined with Tenecteplase, Standard medical treatment
- Where
- China
- Volunteers
- 636 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage, Critically Ill
Early Multimodal Neuromonitoring For Spontaneous Intracerebral Hemorrhage (ICH)
The investigators intend to assess the predictive value of early (first 48 hours) multimodal neuromonitoring parameters concerning late survival in critically ill intracerebral hemorrhage (ICH) patients.
- Conditions
- Intracerebral Hemorrhage, Critically Ill, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- NCT05501613
- Testing
- Multimodal Neuromonitoring
- Where
- Portugal
- Volunteers
- 65 people
- Sponsor
- Universidade do Porto
Acute Brain Injury
The NEUROlogically-impaired Extubation Timing Trial
This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs.
- Trial name
- NEURO-ETT (NCT02920580)
- Testing
- Extubation, Usual Care
- Where
- 13 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Sunnybrook Health Sciences Centre
Intracerebral Hemorrhage
Chinese Multicenter Cohort Study of Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage is a severe form of stroke associated with high mortality and long-term disability. The Chinese Multicenter Cohort Study of Intracerebral Hemorrhage (CASA) is a prospective observational…
- Trial name
- CMCS-ICH (NCT07833410)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Primary Disease or Condition Being Studied, or Focus of the Study
Neuropsychiatric Symptoms in Spontaneous Intracerebral Hemorrhage Survivors
Compared to the United Kingdom and the United States, Spontaneous non-traumatic intracerebral hemorrhage (ICH) is more common among people in Taiwan.
- Trial name
- NCT05620810
- Testing
- neuropsychiatric symptoms
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Stroke Hemorrhagic, Intracerebral Haemorrhage
Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial
This study aims to explore the effectiveness of tranexamic acid (also known as trans amine or TXA) in reducing hematoma expansion in patients with hemorrhagic stroke when given in the acute phase.
- Trial name
- TRANSACT (NCT03044184)
- Testing
- Tranexamic Acid
- Where
- Hong Kong
- Volunteers
- 220 people
- Sponsor
- Kwong Wah Hospital
Early Systolic Blood Pressure Control Rate, Hematoma Growth
Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment
This study evaluates safety and efficacy of analgesia-first minimal sedation as an early antihypertensive treatment for spontaneous intracerebral hemorrhage.
- Conditions
- Early Systolic Blood Pressure Control Rate, Hematoma Growth, Blood Pressure Variability, Healthcare Worker Satisfaction
- Trial name
- ASSICHH (NCT03207100)
- Testing
- Analgesia-first minimal sedation, Antihypertensive treatment
- Where
- 17 sites in China
- Volunteers
- 338 people
- Sponsor
- Hong Yang