Clinical trials: Spontaneous Intracerebral Hemorrhage
Intracranial Hemorrhage, Spontaneous
Prediction of Functional Recovery in Patients With Intracerebral Hemorrhage
Currently, we lack sufficiently reliable tools to accurately predict, in the first few hours, the vital prognosis, functional status, and quality of life of patients with intracerebral hemorrhage (ICH).
- Trial name
- PRO-ICH (NCT07728734)
- Testing
- CLINICAL SCORE TO PREDICT FUNCTIONAL OUTCOME, Variables necessary for calculating the score under study (PRO-ICH) will be collected, as well as baseline and 60-120 minutes after baseline of serum blood samples
- Where
- Spain
- Volunteers
- 1,688 people
- Sponsor
- Germans Trias i Pujol Hospital
Basal Ganglia Hemorrhage, Intraventricular Hemorrhage
RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH
Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited.
- Conditions
- Basal Ganglia Hemorrhage, Intraventricular Hemorrhage, Brainstem Stroke, Intracranial Hemorrhage, Spontaneous
- Trial name
- RAINBOW-ICH (NCT07205263)
- Testing
- AI-assisted robotic-guided endoscopic hematoma evacuation, Conventional craniotomy, AI-assisted robotic-guided puncture and hematoma evacuation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracranial Hemorrhages
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Spontaneous Intracerebral Hemorrhage
The purpose of this study is to determine whether treatment with remote ischemic conditioning is of sufficient promise to improve outcome before conducting a larger clinical trial to examine its effectiveness as a treatment for…
- Trial name
- SERIC-sICH (NCT03484936)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Yi Yang
Spontaneous Intracerebral Hemorrhage
Efficacy of Prophylactic Levetiracetam for Improving Functional Outcome in the Acute Phase of Intracerebral Haemorrhage: a Randomised, Double-blind, Placebo-controlled, Phase 3 Trial
Epileptic seizures are a common complication at the acute phase of intracerebral haemorrhage (ICH). The incidence of seizures occurring within 7 days reaches 40% when subclinical seizures are diagnosed by continuous…
- Trial name
- PEACH2 (NCT07336992)
- Testing
- Neuroimaging, National Institute of Health Stroke Scale (NIHSS), Modified Rankin Scale (mRS)
- Where
- France
- Volunteers
- 580 people
- Sponsor
- Hospices Civils de Lyon
Intracranial Hemorrhages
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
The overall goal is to establish the safety and efficacy of colchicine in ICH patients for the prevention of major cardiovascular events and brain injury.
- Trial name
- CoVasc-ICH (NCT05159219)
- Testing
- Colchicine Pill
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Intracerebral Hemorrhage
Multicentre Registry of Patients With Spontaneous Acute Intracerebral Hemorrhage in Catalonia (HIC-CAT).
A population-based registry in Catalonia of patients with acute spontaneous Intracerebral Hemorrhage, to investigate whether type of center and time from onset to admission is associated with functional outcome and mortality.
- Trial name
- HIC-CAT (NCT03956485)
- Testing
- Type of center
- Where
- 26 sites in Spain
- Volunteers
- 2,500 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hemorrhage, Intracranial, Outcome Measure
Clinical Characteristics and Outcome of Patients With Hemorrhagic Stroke Admitted in Neurology Department in a Tertiary Hospital
The main aim of this study is to know about the clinical profile of patients who are diagnosed as hemorrhagic stroke as well as the factors that affect good and bad outcomes of those patients after 3 months.
- Trial name
- NCT06824311
- Where
- Nepal
- Volunteers
- 197 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Intracerebral Hemorrhage Lobar
Neuronavigation-assisted Stereotactic Minimally Invasive Puncture With Tenecteplase for Acute Lobar Intracerebral Hemorrhage
Introduction: Minimally invasive puncture surgery with thrombolysis is effective for hypertensive intracerebral hemorrhage, but its effect on neurological recovery remains uncertain.
- Trial name
- NALICE-TNK (NCT07471256)
- Testing
- Neuronavigation-assisted Stereotactic Minimally Invasive Puncture Combined with Tenecteplase, Standard medical treatment
- Where
- China
- Volunteers
- 636 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Haemorrhage
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage (EMINENT-ICH)
This is an open-labelled, single centre randomised controlled trial evaluating the efficacy of early minimally invasive image-guided hematoma evacuation in combination with the current best medical treatment compared to best…
- Trial name
- EMINENT-ICH (NCT05681988)
- Testing
- Early minimally invasive image guided endoscopic hematoma evacuation, Best medical treatment (BMT)
- Where
- 10 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Hemorrhage Stroke
Hemorrhage Stroke Decision Making Model Based Deep Learning (BrainHemoAI System)
Although hemorrhagic stroke also has the characteristics of high mortality and disability rates, and constitutes a major public health problem worldwide, there is a relative lack of in-depth research teams for hemorrhagic stroke…
- Trial name
- NCT07570680
- Testing
- Large language model
- Where
- China
- Volunteers
- 7,100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Intracerebral Haemorrhage in Cerebellum
Vitamin K1 in the Treatment of Spontaneous Intracerebral Hemorrhage
In order to determine the effectiveness and safety of early vitamin K1 use in reducing the risk of bleeding and improving prognosis in patients with spontaneous intracerebral hemorrhage.
- Trial name
- NCT03388970
- Testing
- Vitamin K 1, normal saline
- Where
- 5 sites in China
- Volunteers
- 400 people
- Sponsor
- HUANG XIANJIAN
Spontaneous Intracranial Hemorrhage, Hypertension
Tranexamic Acid with Intensive Blood Pressure Management in Ultra-Early Intracerebral Hemorrhage
This is a prospective, multicenter, randomized, quadruple-blind, placebo-controlled study. This study aims to estimate the safety and efficacy of intravenous tranexamic acid (TXA) combined with intensive blood pressure lowering…
- Trial name
- TIME-ICH (NCT06760078)
- Testing
- intravenous tranexamic acid (TXA) infusion
- Where
- 2 sites in China
- Volunteers
- 532 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke Hemorrhagic, Intracerebral Haemorrhage
Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial
This study aims to explore the effectiveness of tranexamic acid (also known as trans amine or TXA) in reducing hematoma expansion in patients with hemorrhagic stroke when given in the acute phase.
- Trial name
- TRANSACT (NCT03044184)
- Testing
- Tranexamic Acid
- Where
- Hong Kong
- Volunteers
- 220 people
- Sponsor
- Kwong Wah Hospital
Spontaneous Intracerebral Hemorrhage
Longitudinal Cohort Study on ICH Care
Intracerebral hemorrhage [ICH] is the most feared sub-type of stroke, associated with a high mortality rate up to 50% and thus leaving large proportions of patients in functionally dependent states.
- Trial name
- UKER-ICH (NCT03183167)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 1,076 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Intracerebral Hemorrhagic Stroke
Indian Trial of Tranexamic Acid in Spontaneous Intracerebral Haemorrhage
This multicenter, pragmatic randomized, open-label clinical trial aims to assess whether Tranexamic Acid improves outcomes in adult patients with spontaneous intracerebral haemorrhage.
- Trial name
- NCT05836831
- Testing
- Tranexamic acid injection
- Where
- 48 sites in India
- Volunteers
- 3,400 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Early Systolic Blood Pressure Control Rate, Hematoma Growth
Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment
This study evaluates safety and efficacy of analgesia-first minimal sedation as an early antihypertensive treatment for spontaneous intracerebral hemorrhage.
- Conditions
- Early Systolic Blood Pressure Control Rate, Hematoma Growth, Blood Pressure Variability, Healthcare Worker Satisfaction
- Trial name
- ASSICHH (NCT03207100)
- Testing
- Analgesia-first minimal sedation, Antihypertensive treatment
- Where
- 17 sites in China
- Volunteers
- 338 people
- Sponsor
- Hong Yang
Cerebral Hemorrhage
Restart Anticoagulation in Patients With Spontaneous Intracerebral Hemorrhage and Mechanical Heart Valves
The investigators retrospectively reviewed the electronic medical records of the patients with spontaneous cerebral hemorrhage and mechanical valves from 2015 to 2020 in the second affiliated hospital of Zhejiang university…
- Trial name
- NCT04450446
- Testing
- Low molecular weight heparin
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebral Hemorrhage
REstart or STop Antithrombotic Randomised Trial in France
RESTART- fr is a randomised controlled trial for adults surviving spontaneous intracerebral haemorrhage who had taken an antithrombotic drug (i.e.
- Trial name
- RESTART-Fr (NCT02966119)
- Testing
- Clopidogrel or Aspirin and/or Dypyridamole
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Lille
Stroke, Acute, Intracerebral Hemorrhage
Prospective Cohort of Patients With Intracerebral Hemorrhage
The investigators designed a multicentral, observational, prospective cohort study to provide cortical data for risk stratification and biomarkers on early outcomes, complications, long-term neurological function, and cognitive…
- Trial name
- NCT06670456
- Where
- 6 sites in China
- Volunteers
- 3,000 people
- Sponsor
- De-zhi Kang
Disorders of Consciousness, Spontaneous Intracerebral Hemorrhage
Transcutaneous Auricular Vagus Nerve Stimulation for Recovery of Consciousness After Surgery for Spontaneous Intracerebral Hemorrhage
Disorders of consciousness are common after surgery for severe spontaneous intracerebral hemorrhage and are associated with high mortality, disability, and long-term dependence.
- Trial name
- TAVNS-SICH (NCT07761507)
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Beijing Tiantan Hospital