Clinical trials: Spontaneous Intracranial Hypotension
Spontaneous Intracranial Hypotension
CVFs in SIH: EID vs. PCD CTM
The purpose of this research study is to compare two types of Computed Tomography Myelography (CTM) scans, one on the photon counting detector scanner (called PCD-CTM) and the other on the energy integrating detector scanner…
- Trial name
- NCT07582744
- Testing
- photon counting detector CT myelography (PCD- CTM), energy integrating detector CT myelography (EID-CTM)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Spontaneous Intracranial Hypotension, Intracranial Hypotension
Pathophysiology and Treatment of Cerebrospinal Hypotension Exploration Study
The goal of this observational study is to learn about the effects of a low-pressure environment on the brain in patients with intracranial hypotension and to potentially improve diagnostics and treatment of this condition.
- Conditions
- Spontaneous Intracranial Hypotension, Intracranial Hypotension, Post-Lumbar Puncture Headache
- Trial name
- PATCHES (NCT06805591)
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Spontaneous Intracranial Hypotension
Spontaneous Intracranial Hypotension Treatment "SIHT"
Spontaneous intracranial hypotension (SIH) is an infrequent disease, related to a leak of cerebrospinal fluid. There are not controlled studies for this treatment.The main of this study is to demonstrate the superiority of the…
- Trial name
- SIHT (NCT02261792)
- Testing
- 24 hours Trendelenburg position, 24 hours bed rest, EBP
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Subdural Hematoma
Spinal CSF Leaks in Chronic Subdural Hematoma
Background: Chronic subdural hematoma (cSDH) is a type of intracranial bleeding, predominantly affecting the elderly and males, with an estimated incidence of 8/100.000.
- Trial name
- SPICE (NCT06323434)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Freiburg
Spontaneous Intracranial Hypotension
A Clinical Registry of Spontaneous Intracranial Hypotension
The purpose of this research is to determine the efficacy of paraspinal vein embolization for treatment of digital subtraction myelography (DSM) or CT myelography (CTM) confirmed cerebrospinal fluid (CSF)-venous fistulas so that…
- Trial name
- NCT05922514
- Testing
- Transvenous Embolization of Cerebrospinal Fluid-Venous Fistula
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
Hyperprolactinemia, Spontaneous Intracranial Hypotension
Pituitary Function and Spontaneous Intracranial Hypotension
Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns.
- Trial name
- NCT02603549
- Testing
- Pituitary panel will be drawn pre-op and post-op for all patients.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Cerebrospinal Fluid Leaks
A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment
The goal of this randomized controlled trial (RCT) is to compare the efficacy of CT fluoroscopy-guided targeted epidural patching for treatment of imaging-confirmed spinal CSF leaks to that of a simulated procedure without…
- Trial name
- NCT03276975
- Testing
- TISSEEL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Spontaneous Intracranial Hypotension
Blind Versus Targeted Epidural Patch With Autologous Platelet-rich Plasma for Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to loss of cerebrospinal fluid (CSF).
- Trial name
- NCT07283536
- Testing
- Targeted epidural PRP patch, Blind epidural PRP patch
- Sponsor
- Beijing Tiantan Hospital
Intracranial Hypotension
Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension
The purpose of this study is to estimate the intracranial pressure (ICP, the pressure in your head) in subjects with intracranial hypotension (a condition caused by leakage of the fluid that surrounds your brain and spine) using…
- Trial name
- NCT03041441
- Testing
- MRI algorithm, Lumbar puncture, Epidural patching
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Spontaneous Intracranial Hypotension
Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension
Spontaneous Intracranial Hypotension (SIH) is a debilitating neurological disorder caused by a cerebrospinal fluid leak (CSF), with an estimated incidence of 5 per 100,000 persons per year, of which mostly women between the ages…
- Trial name
- NCT06374524
- Testing
- greater occipital nerve block
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Spontaneous Intracranial Hypotension
ONSD Changes and Treatment Response After Epidural Blood Patch in Spontaneous Intracranial Hypotension
"This is a prospective observational study investigating changes in optic nerve sheath diameter (ONSD) and its association with clinical improvement following epidural blood patch (EBP) in patients with spontaneous intracranial…
- Trial name
- NCT07085260
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Yonsei University