Clinical trials: Squamous Cell Carcinoma of Glottis
Head and Neck Squamous Cell Carcinoma, Glottic T1
DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer
To evaluate whether Transoral Laser Microsurgery (TLM) is non-inferior compared to Accelerated Radiotherapy (accRT) in the treatment of T1aN0M0 glottic SCC
- Trial name
- DAHANCA 27 (NCT05289336)
- Testing
- Transoral Laser Microsurgery
- Where
- 5 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Danish Head and Neck Cancer Group
Early Stage Glottic Squamous Cell Carcinoma With Poor Differentiation
Role of Radiotherapy in T1-T2N0M0 Glottic Carcinoma With Poor Differentiation
There remains no uniform treatment modality for glottic laryngeal carcinoma. Current clinical guidelines broadly recommend surgery or radiotherapy as single-modality treatment for early-stage glottic laryngeal carcinoma.
- Trial name
- NCT07781098
- Testing
- Radiation: intensity modulated radiotherapy (IMRT)
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glottis Tumor, Larynx Cancer
VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer
Laser surgery and radiotherapy are well-established standards of care for unilateral stage 0 \& I carcinoma in situ (Cais) and squamous cell carcinoma of glottic larynx (SCCGL).
- Trial name
- VoiceS (NCT04057209)
- Testing
- Single Vocal Cord Irradiation (SVCI), Arm A: Transoral CO2-Laser Microsurgical Cordectomy (TLM)
- Where
- 4 sites in France, India and 1 more
- Volunteers
- 34 people
- Sponsor
- Olgun Elicin
Early Stage Glottic Squamous Cell Carcinoma Involving the Anterior Commissure
Role of Postoperative Radiotherapy in T1-T2N0M0 Glottic Carcinoma Involving the Anterior Commissure
There remains no uniform treatment modality for glottic laryngeal carcinoma. Current clinical guidelines broadly recommend surgery or radiotherapy as single modality treatment for early stage glottic laryngeal carcinoma.
- Trial name
- NCT07781085
- Testing
- intensity modulated radiotherapy (IMRT)
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Squamous Cell Carcinoma of Glottis
CO2 Laser and Open Surgery for T1N0 Glottic SCC With Anterior Commissure Involved
Open surgery and CO2 laser surgery are both established treatment modalities for T1N0 glottic carcinoma. It is controversial for T1N0 glottic carcinoma with anterior commissure involved.
- Trial name
- NCT02303457
- Testing
- CO2 Laser surgery, Open Surgery
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Xuekui Liu
Glottic Carcinoma
Comparison of Voice Results at 5 Years of Treatment of Glottic Squamous Cell Carcinoma T1 by Surgery Versus Radiotherapy
Patients with early-stage squamous cell carcinomas of the vocal cord can be treated in an equivalent way in terms of carcinology by surgery or radiotherapy.
- Trial name
- VO Qual (NCT04447456)
- Where
- 2 sites in France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Lille
Head and Neck Cancer, Oropharynx Cancer
Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer
The purpose of this study is to evaluate the safety of adding the investigational drug Motexafin Gadolinium to the standard treatment of radiation therapy and chemotherapy with drugs called 5-FU and cisplatin in patients with…
- Conditions
- Head and Neck Cancer, Oropharynx Cancer, Larynx Cancer, Hypopharynx Cancer
- Trial name
- NCT00080028
- Testing
- Motexafin Gadolinium Injection
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Pharmacyclics LLC.
Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma
Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma
Objectives: Transoral Laser Microsurgery (TLM) is widely used in for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is a safe and commonly-used injectable in vocal cord augmentation.
- Conditions
- Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma, Voice Disorders, Laryngeal Cancer
- Trial name
- NCT04525066
- Testing
- Hyaluronic acid, No Hyaluronic Acid Injection Injection
- Volunteers
- 39 people
- Sponsor
- Ayhman Al Afif
Head and Neck Cancer
Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis
RATIONALE: Endoscopic surgery is a less invasive type of surgery for laryngeal cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00334997
- Testing
- endoscopic surgery, laser surgery, radiation therapy
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College London Hospitals