Clinical trials: Stability
Patients With Initially Unresectable MSS-type Advanced Colorectal Cancer With Liver and/or Lung and Peritoneal Metastasis
Modified Short-Course Radiotherapy Combined With Immunochemotherapy and Targeted Therapy as First-Line Treatment for MSS Metastatic Colorectal Cancer
This is a single-arm interventional study targeting patients with initially unresectable MSS-type advanced colorectal cancer with liver and/or lung and peritoneal metastasis.
- Trial name
- NCT07512674
- Testing
- Receiving lymph node-sparing modified short-course radiotherapy combined with tislelizumab, CAPOX chemotherapy and bevacizumab targeted therapy
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Sir Run Run Shaw Hospital
Colorectal Neoplasms
A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal Cancer
The purpose of this study is to evaluate relatlimab in combination with nivolumab, administered as a fixed-dose combination (nivolumab-relatlimab FDC, also referred to as BMS-986213) for the treatment of non-microsatellite…
- Trial name
- RELATIVITY-123 (NCT05328908)
- Testing
- Nivolumab-relatlimab FDC, Regorafenib, TAS-102
- Where
- 139 sites in United States, Argentina and 20 more
- Volunteers
- 769 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections
Tenofovir DF + Efavirenz (TDF+EFV) Versus Tenofovir DF + Efavirenz + Lamivudine (TDF+EFV+3TC) Maintenance Regimen in Virologically Controlled Patients: COOL Trial
Primary objective: Evaluation of the efficacy of TDF+3TC+EFV versus TDF+EFV QD to maintain plasma HIV-1 RNA BLQ (< 50 copies/mL) (c/mL) at 48 weeks (W48) Main Secondary objectives: Comparison of the two arms for genotypic…
- Trial name
- COOL (NCT00643968)
- Testing
- EFV+TDF, EFV+3TC+TDF
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Gilead Sciences
Vertigo, Vertigo, Peripheral
Effectiveness of Gaze Stability Exercises on Balance and Activities of Daily Living Among Patients Suffering Vertigo With Vestibular Neuritis in Saudi Arabia
Gaze stability exercise is a medical procedure for persons with unilateral vestibular disturbances such as vestibular neuritis or persons who have had tumors of their 8th nerve.
- Conditions
- Vertigo, Vertigo, Peripheral, Vertigo Labyrinthine, Migraine
- Trial name
- NCT04842474
- Testing
- Gaze stability exercises and balance exercises
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- King Saud University
Primary Stability of the Implants, Marginal Bone Loss
Inferior Alveolar Nerve Lateralization With Simultaneous Implant Placement Versus the Use of Short Dental Implants
Assess the long term stability of short dental implants in comparison to standard implants inserted simultaneously with inferior alveolar nerve lateralization.
- Trial name
- NCT03661658
- Testing
- Using short dental implant, Inferior alveolar nerve lateralization with simultaneous implant placement
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orthodontic Appliance Complication
Stability of Maxillary Anterior Teeth After Two Years of Retention in Adolescents Comparing Two Bonded and a Vacuum-formed Retainer
After orthodontic treatment 3 different retention devices will be compared.Thirty patients in each group; Group 1) Bonded retainer 13-23, Group 2)Bonded retainer 12-22 and Group 3) Vacuum-formed retainer covering all erupted…
- Trial name
- NCT04616755
- Testing
- Measuring changes of Little´s irregularity index ( sum of 5 contact point discrepancies together) measured in mm 2 years after retention have been I place.
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kronoberg County Council
Implant Stability and Osseointegration, Laser Effect Around Dental Implant
Osseo Densification Technique and LLLT in DD Implant
A comparative clinical study on 16 patients with Type IV bone, divided into two groups (n=8): implants placed using Densah burs only versus Densah burs combined with laser bio stimulation, to evaluate implant stability and…
- Trial name
- laser (NCT07534826)
- Testing
- implant placement using Densah burs, implantation using Densah burs with Laser biostimulation
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Faculty of Dental Medicine for Girls
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Age Related Macular Degeneration
Wet AMD Recurrence Rate in Patients Stable on Three Month Ranibizumab Dosing
The current norm in clinical practice for the treatment of choroidal neovascular membranes (CNVM) secondary to Age-related Macular Degeneration(AMD) involves monthly injections of Ranibizumab until the disease is stabilized.
- Trial name
- NCT01453920
- Testing
- Ranibizumab
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Multiple Sclerosis
Virtual Reality in Physical Therapy in Multiple Sclerosis
The randomized controlled trial is aimed to study the efficacy of virtual reality (VR) and its impact on upper limb function and postural stability in people with mild to severe multiple sclerosis (pwMS).
- Trial name
- VIREMS (NCT04807738)
- Testing
- Neuroproprioceptive "facilitation and inhibition" in virtual reality, Neuroproprioceptive "facilitation and inhibition"
- Where
- 2 sites in Czechia
- Volunteers
- 71 people
- Sponsor
- Charles University, Czech Republic
Healthy, Chronic Stable Illness
COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult Volunteers
The primary objectives of the study are: To evaluate the extent of effect, if any, of REGN10933+REGN10987 administration on vaccine-induced neutralizing antibody responses to SARS-CoV-2 by Moderna mRNA-1273 To evaluate the time…
- Trial name
- NCT04852978
- Testing
- casirivimab+imdevimab, Moderna mRNA-1273 vaccine
- Where
- 6 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Resin Composite Restorations, Esthetic Restorations
Color Stability and Wear Resistance of Direct Flowable and Preheated Composite Using the Injectable Technique
The aim of this study is to conduct the first clinical trial to assess the color stability and wear resistance of the highly filled injectable flowable composite materials compared to preheated conventional ones and evaluate the…
- Trial name
- NCT06532916
- Testing
- Experimental: Group1: Estelite Sigma Quick, Experimental: Group 2: Estelite Flow Quick
- Where
- Jordan
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Colorectal Cancer
Immunotherapy Combined With Y-90 and SBRT for Colorectal Liver Metastases
This study is evaluating the combination of Y-90 radioembolization followed by SBRT with the immunotherapy drugs, durvalumab and tremelimumab, to improve disease control of liver metastases for patients with microsatellite stable…
- Trial name
- NCT03802747
- Testing
- Durvalumab, Durvalumab and Tremelimumab, Y-90 Selective Internal Radiation Therapy (SIRT)
- Sponsor
- University of Colorado, Denver
Shoulder Injuries
Effect of Thrower's Ten Exercise Program on Shoulder Flexibility, Stability and Strength in Water Polo Players
Context: Studies have shown that the thrower's ten rehabilitation program is effective in the prevention and rehabilitation of injuries in overhead throwing sports. However its effect on water polo sports is still unknown.
- Trial name
- NCT05945238
- Testing
- Thrower's Ten Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baskent University
Relapsing Remitting Multiple Sclerosis
Safety Study of Olesoxime in Patients With Stable Relapsing Remitting Multiple Sclerosis Treated With Interferon Beta.
This is a 24-week phase 1b, randomized, double-blind, placebo-controlled, parallel-group, multicenter safety study comparing the tolerance profile of olesoxime (495 mg, od) when administered on top of Interferon beta in patients…
- Trial name
- MSREPAIR (NCT01808885)
- Testing
- olesoxime (TRO19622)
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- Hoffmann-La Roche
Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma
Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer
This phase II trial studies how well the combination of botensilimab, balstilimab and regorafenib works compared to botensilimab and balstilimab in treating patients with microsatellite stable colorectal cancer that may have…
- Conditions
- Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma, Advanced Rectal Adenocarcinoma, Metastatic Colon Adenocarcinoma
- Trial name
- NCT06575725
- Testing
- Balstilimab, Biopsy, Biospecimen Collection
- Sponsor
- City of Hope Medical Center
Older Adults, Balance, Dance
Dance and Blood Flow Restriction as Balance Training for Older Women
Falls are one of the leading causes of hospitalization and mortality among older adults (aged 65+) in Canada. Falls result from postural instability following age-related declines in muscle strength which begin in the 5th decade…
- Conditions
- Older Adults, Balance, Dance, Blood Flow Restriction (BFR) Training Effects, Telehealth
- Trial name
- NCT07011784
- Testing
- Blood flow restriction in combination with dance classes, Dance classes alone
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Missing Teeth, Edentulous Alveolar Ridge
Hybrid Funnel Technique a Innovative Technique for Implant Site Preparation
Hybrid Funnel Technique arises from the union of subtractive and non-subtractive techniques for implant site preparation. Hybrid funnel technique is performed with specially designed drills and osteotome.
- Conditions
- Missing Teeth, Edentulous Alveolar Ridge, Tooth Loss
- Trial name
- NCT05499533
- Testing
- implant site preparation
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Luigi Canullo
Chronic Obstructive Pulmonary Disease, Inflammation
Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
COPD is a progressive pulmonary disease that is characterized by an inflammatory process in the airways and the lungs which leads to progressive airway obstruction. The inflammation is associated with tissue loss and remodelling.
- Conditions
- Chronic Obstructive Pulmonary Disease, Inflammation, Pulmonary Emphysema
- Trial name
- NCT00857038
- Testing
- Doxycycline
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Center Alkmaar
Chronic Heart Failure
A Phase IIb Study of AZD5462 in Patients With Chronic Heart Failure
The main purpose of this study is to evaluate the effect of AZD5462 on cardiac function in participants with chronic heart failure (HF).
- Trial name
- LUMINARA (NCT06299826)
- Testing
- AZD5462
- Where
- 57 sites in United States, Bulgaria and 8 more
- Volunteers
- 375 people
- Sponsor
- AstraZeneca
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.