Clinical trials: Stable Coronary Heart Disease
Chest Pain, Stable Angina Pectoris, CCS Class I to III
Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations
This randomized, controlled, diagnostic, multicenter trial will compare two diagnostic imaging pathways--coronary computed tomography angiography (CCTA) and single photon emission tomography (SPECT) myocardial perfusion imaging…
- Conditions
- Chest Pain, Stable Angina Pectoris, CCS Class I to III, Angina Equivalent, Coronary Artery Disease
- Trial name
- RESCUE (NCT01262625)
- Testing
- CCTA, SPECT MPI/ICA
- Where
- 3 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- American College of Radiology
Cardiovascular Diseases
Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina
The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery.
- Trial name
- NITRATE-OCT (NCT02529189)
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Queen Mary University of London
Ventricular Tachycardia
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.
- Trial name
- NCT02419547
- Testing
- Versed, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Chronic Heart Failure
Nurse-Led Education for Heart Failure Self-Care and Stability
Heart failure is a chronic condition that can lead to frequent hospitalizations and reduced quality of life. This study aims to evaluate whether a nurse-led, face-to-face educational intervention can improve clinical stability…
- Trial name
- EDUCATE (NCT07280728)
- Testing
- Nurse-Led Face-to-Face Educational Intervention (Teach-Back Method)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Coronary Artery Disease, Stable Angina
Functional Assessment of Myocardial Ischemia by Intracoronary Electrocardiogram
In patients with chronic stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) targets hemodynamically significant coronary lesions, i.e., those thought to cause inducible ischemia.
- Conditions
- Coronary Artery Disease, Stable Angina, Coronary Artery Stenosis, Ischemia
- Trial name
- FFRicECG (NCT03985241)
- Testing
- Functional Assessment of Myocardial Ischemia by icECG
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Coronary Syndrome, Angina Pectoris, Unstable
Incremental Value of Point of Care H-FABP Testing in Primary Care Patients Suspected of Acute Coronary Syndrome
Rationale: Thoracic complaints, possibly due to a cardiac ischemic cause are a diagnostic challenge in general practice. When an underlying ischemic cardiac condition (AMI (acute myocardial infarction), UAP (unstable angina…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Unstable, Angina Pectoris, Stable, Thoracic Diseases
- Trial name
- RAPIDA (NCT01826994)
- Testing
- heart type fatty acid binding protein testing
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 303 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease, Acute Coronary Syndrome
PGD2 Formation in Vascular Injury
To investigate the biosynthesis of PGD2 during percutaneous transluminal coronary angioplasty (PTCA) procedure.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Stable Angina
- Trial name
- PGD2 (NCT01001260)
- Testing
- No ASA, Low dose ASA, 325 mg ASA
- Volunteers
- 51 people
- Sponsor
- University of Pennsylvania
Potassium Imbalance, Cardiac Arrhythmia
The Effect of Potassium Lowering Drugs on Cardiac Electrical Stability in Hemodialysis Patients (ART Study)
This study is a multicenter, prospective and randomized controlled study. The experiment includes a 1-week screening period (1 week before dialysis) and a 7-week treatment period (1-4 weeks of dose drip period and 5-7 weeks of…
- Conditions
- Potassium Imbalance, Cardiac Arrhythmia, Dialysis; Complications
- Trial name
- NCT06242041
- Testing
- sodium zirconium cyclic silicate
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Peking University First Hospital
Cardiovascular Diseases, Myocardial Infarction
Exercise as a Life-long Medicine in Patients With Coronary Artery Disease
Exercise training is a core component in cardiac rehabilitation. Exercise adherence is, however, low after rehabilitation and the transition from supervised to unsupervised exercise is problematic for many patients with coronary…
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Angina (Stable)
- Trial name
- NCT02228603
- Testing
- high-intensity exercise training, web-based follow-up program, usual care
- Where
- 2 sites in Norway
- Volunteers
- 161 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Disease
CT Calcium Scoring in Suspected Stable Angina
Patients with stable chest pain presenting to general practitioners in UK are routinely referred to the chest pain clinics in the hospitals.
- Trial name
- NCT01660594
- Testing
- CT calcium scoring
- Where
- United Kingdom
- Volunteers
- 705 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease
PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEF
To evaluate whether percutaneous coronary intervention (PCI) with contemporary drug-eluting stents (DES) combined with guideline-directed medical therapy (GDMT), compared to GDMT alone, reduces the time to first occurrence of…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease, Stable GDMT
- Trial name
- PCI-GULF (NCT07349979)
- Testing
- Percutaneous coronary intervention, Guideline-directed medical therapy
- Where
- China
- Volunteers
- 1,154 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stable Angina, Unstable Angina
Assessment of Diagonal Branch Territory
This study was performed to investigate the anatomical attributes that determine myocardial territory of diagonal branches and to develop a prediction model for clinically relevant branches using myocardial perfusion imaging…
- Trial name
- NCT03935542
- Where
- South Korea
- Volunteers
- 355 people
- Sponsor
- Bon-Kwon Koo
Cervical Intraepithelial Neoplasia
Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization
Cervical conization is done for pre-cancer disease. The procedure is performed with local anesthesia and general anesthesia. Local anesthesia is given by paracervical block, and several different local anesthetics is being used…
- Trial name
- HSBAPCB (NCT02368054)
- Testing
- Bupivacaine, Adrenaline
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- Helse Fonna
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Angina (Stable)
Coronary Sinus Reducer Therapy for Persisting Angina
Refractory angina due to advanced obstructive coronary artery disease (CAD) remains a major clinical problem with limited evidence-based treatment options.
- Trial name
- REDUCE ANGINA (NCT07485985)
- Testing
- Coronary sinus reducer
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Stable Angina, Positive ETT
Diagnostic Value of HS-CRP in Stable Angina.
The aim of this study was to assess the amount of additive value of HS-CRP levels to a positive exercise tolerance test (ETT) in predicting coronary artery disease (CAD) using coronary angiography as the gold standard.
- Trial name
- NCT00719992
- Testing
- coronary angiography
- Where
- Iran
- Volunteers
- 97 people
- Sponsor
- Shiraz University of Medical Sciences
Coronary Artery Disease, Dyslipidemia
The Impact of Tredaptive on Flow-Mediated Dilation in Cardiac Patients
Laropiprant (LRP; Merck \& Co., Inc, Whitehouse Station, NJ, USA) is a potent, once-daily, highly selective PGD2-receptor (DP1) antagonist.
- Trial name
- NCT01052311
- Testing
- Tredaptive (1 g extended release niacin+ 20 mg laropiprant), Tredaptive
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Sheba Medical Center
Coronary Artery Disease
Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease
This is a randomized double-blind, placebo-controlled, investigator-initiated trial that compares Colchicine 0.5mg/day with placebo, among patients with stable CAD.
- Trial name
- EKSTROM (NCT06342609)
- Testing
- Colchicine 0.5 MG
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Stable Angina
Safety and Efficacy Study of Endothelial Progenitor Cell Capture Stent With 1 Months Dual Antiplatelet Therapy
Thanks to rapid reendothelialization derived from the pro-healing property of the EPC capture stent, 1-month dual antiplatelet therapy (DAPT) is recommended after EPC capture stent implantation.
- Trial name
- INNOVATION (NCT01394848)
- Testing
- Endothelial cell capture stent with 1 month clopidogrel, Everolimus eluting stent with 12 month clopidogrel, Atorvastatin 20mg loading
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Yonsei University
Chronic Stable Angina
A Randomized, Open-label, Single-dose, Crossover Clinical Trial to Evaluate the Food Effect on the Pharmacokinetics of Dilatrend SR 64mg Capsule After Oral Administration in Healthy Male Volunteers
A randomized, open-label, single-dose, crossover clinical trial to evaluate the food effect on the pharmacokinetics of Dilatrend SR 64mg capsule after oral administration in healthy male volunteers.
- Trial name
- NCT01340248
- Testing
- Dilatrend 64mg capsule
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical