Clinical trials: Stable Coronary Heart Disease
Atrial Fibrillation, Venous Thromboembolism
Prothrombin Times Outside the Therapeutic Range in Otherwise Stable Patients
Warfarin is very effective for the prevention of blood clots (thrombosis). A test of coagulation, the prothrombin time (PT) is used to monitor the effect.
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Ischemic Stroke, Myocardial Infarction
- Trial name
- FORESPEAK-0 (NCT00814177)
- Testing
- warfarin
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Hamilton Health Sciences Corporation
Coronary Artery Disease, Stable Angina
Comparison of Left and Right Transradial Approach for CAG and PCI
This trial will compare the procedural success rate between right and left radial approach in patients undergoing coronary angiography and coronary intervention.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction
- Trial name
- COMPARE-Rad (NCT03389503)
- Testing
- Radial approach
- Where
- South Korea
- Volunteers
- 322 people
- Sponsor
- Wonju Severance Christian Hospital
Atherosclerosis
Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)
Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated…
- Trial name
- CANTOS (NCT01327846)
- Testing
- Canakinumab, Standard of care
- Where
- 1,131 sites in United States, Argentina and 38 more
- Volunteers
- 10,066 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease
Role of Cardiac CT in Rapid Access Chest Pain Clinics (RADICAL)
Heart disease remains the most common cause of death in the UK. Chest pain is often the first presenting symptom in patients with heart disease, and may be a warning signal prior to a heart attack or death.
- Trial name
- RADICAL (NCT01464203)
- Testing
- CT coronary angiography, Standard of Care
- Where
- 3 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- AJAY YERRAMASU
Myocardial Infacrtion, Unstable Angina Pectoris
BASIC VALIDATE Coronary Stent Registry
BASIC VALIDATE is a coronary stent registry to obtain clinical follow-up information from 2000 patients treated with CE-marked stent (BioMatrix Flex™, Biosensors International) with follow-up of endpoints via the Swedish…
- Conditions
- Myocardial Infacrtion, Unstable Angina Pectoris, Stable Angina Pectoris
- Trial name
- NCT02165670
- Testing
- Coronary stenting with CE-marked stent
- Sponsor
- Region Örebro County
Stable Angina, Unstable Angina
Optical Coherence Tomography Comparison of Neointimal Coverage Between CRE8 DES and BMS
The purpose of the study is to demonstrate the non-inferiority of Cre8 (CID) Drug Eluting Stent, studied 3 months after implant, compared to Vision/Multilink8 Bare Metal Stent (Abbott) studied at 1 month, in terms of neointimal…
- Conditions
- Stable Angina, Unstable Angina, NSTEMI
- Trial name
- DEMONSTRATE (NCT01543373)
- Testing
- Amphilimus Eluting Stent, Bare Metal Stent
- Where
- 6 sites in Italy, Netherlands
- Volunteers
- 38 people
- Sponsor
- CID - Carbostent & Implantable Devices
Coronary Artery Disease
Comparison of Paclitaxel-Coated Balloons Against Drug-Eluting Bioresorbable Scaffolds for Elective PCI Using OCT
This prospective randomized clinical trial aims to compare two different "metal-free" strategies for elective percutaneous coronary revascularization: the FFR-guided DCB-only PCI (drug-coated balloon: SeQuent Please™, B Braun…
- Trial name
- OCTOPUS-3 (NCT02607241)
- Testing
- OCT-guided BRS implantation, FFR-guided DCB-only PCI
- Where
- Germany
- Volunteers
- 59 people
- Sponsor
- University of Jena
Stable Coronary Disease
The Impact of Pcsk-9 Inhibition on PET CFR in Patients at High CV Risk
The study protocol is a single-arm, open label pilot study designed to evaluate the impact of PCSK-9 inhibition on coronary blood flow in patients with stable coronary artery disease.
- Trial name
- EMPOWER (NCT05152888)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure
Safety/Tolerability, Pharmacokinetics/Pharmacodynamics (PK/PD) of LCZ696 in Patients With Stable Heart Failure
This study assess the safety/tolerability, PK/PD of LCZ696 in patients with stable heart failure.
- Trial name
- NCT00913653
- Testing
- LCZ696
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Chronic Sildenafil Treatment in Heart Failure
In heart failure (HF), a defective nitric oxide (NO) signaling may be involved in left ventricular (LV) diastolic abnormalities and LV remodelling progression.
- Trial name
- NCT00975494
- Testing
- Sildenafil
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Stable Angina Pectoris, Coronary Artery Disease
Comprehensive Cardiac CT Versus Exercise Testing in Suspected Coronary Artery Disease (2)
Multi-center, randomized-controlled trial comparing a comprehensive cardiac CT protocol with standard stress testing in patients with stable chest pain complaints.
- Trial name
- CRESCENT2 (NCT02291484)
- Testing
- Cardiac CT scan
- Where
- 4 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Erasmus Medical Center
Stable Coronary Heart Disease (CHD)
Ticagrelor China Pharmacokinetic/Pharmacodynamic Study
open label, single centre, randomised, Phase IV, pharmacokinetic, pharmacodynamic, and safety study to evaluate single and multiple doses of 45, 60, and 90 mg of ticagrelor in Chinese patients with stable coronary heart disease
- Trial name
- NCT02064985
- Testing
- Inhibition of Platelet Aggregation by "Brilinta"(Ticagrelor)
- Where
- China
- Volunteers
- 61 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2, Ischemic Heart Disease
Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor
Type 2 diabetes mellitus (type 2 DM) is an important disease with increasing prevalence worldwide. More than 60% of diabetes patients die of CVD.
- Trial name
- NCT03178591
- Testing
- vildagliptin, Dapagliflozin
- Where
- Thailand
- Volunteers
- 43 people
- Sponsor
- Chiang Mai University
Atrial Fibrillation
the Study of STABLE_SR for Persistent Atrial Fibrillation
Background:the ablation outcomes for the treatment of persistent atrial fibrillation are not as satisfactory as paroxsymal AF. The successful rate ranges from 30%-55%.
- Trial name
- STABLE-SR (NCT01761188)
- Testing
- Ablation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Slow Coronary Flow, Normal, or Near Normal Coronary Angiography
Effects of Nicorandil on Angina Symptoms in Patients With Coronary Slow Flow
Slow coronary flow is an angiographically diagnosed phenomenon defined as delayed opacification of epicardial arteries in the absence of significant arterial narrowing and blockade.
- Conditions
- Slow Coronary Flow, Normal, or Near Normal Coronary Angiography, Stable Angina
- Trial name
- NCT02254252
- Testing
- Nicorandil, Nitroglycerin
- Volunteers
- 54 people
- Sponsor
- Mashhad University of Medical Sciences
Chronic Coronary Syndrome, Myocardial Ischemia
Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires.
- Conditions
- Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina, Coronary Artery Disease
- Trial name
- PERFORM-CCS (NCT05865600)
- Testing
- Optimization of guideline-directed medical therapy, Immediate referral for invasive coronary angiography, 3-months delayed referral for invasive coronary angiography
- Where
- Denmark
- Volunteers
- 570 people
- Sponsor
- Gødstrup Hospital
Chronic Total Occlusion, Coronary Artery Disease
Risk Factors and Outcomes in Coronary Chronic Total Occlusion
This study aims to assess the risk factors and evaluate the long-term outcomes of patients with coronary chronic total occlusion (CTO) treated with percutaneous coronary intervention or medical treatment.
- Trial name
- NCT06137521
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
Coronary Artery Disease
Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease
1. The number and function of circulating endothelial progenitor cells (EPCs) are inversely associated with coronary risk factors and atherosclerotic diseases such as coronary artery disease (CAD) and cardiovascular high risk. 2.
- Trial name
- NCT02174939
- Testing
- Cilostazol
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Stable Coronary Artery Disease
Mobilization of Endothelial Progenitor Cells Induced by Atorvastatin in Patients With Stable Coronary Artery Disease Treated With Anti-CD 34 Antibodies Coated Stents
The purpose of this study is to evaluate the extent of the mobilization of endothelial progenitor cells induced by low versus high dose atorvastatin after 4 weeks of treatment, in patients treated with anti-CD 34 antibodies…
- Trial name
- NCT00911339
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Angina, Stable Ischemic Heart Disease
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple…
- Trial name
- LIVEBETTER (NCT05786417)
- Testing
- Clinician Discretion, Beta blocker, Calcium channel blocker
- Where
- 10 sites in United States
- Volunteers
- 741 people
- Sponsor
- Yale University