Clinical trials: Stable Coronary Heart Disease
Angina, Stable, Coronary Artery Disease
Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology
The ORACLE study is an observational cohort study designed to explore the feasibility of providing an assessment of chest pain for patients with suspected angina within one working day of referral to specialist services.
- Trial name
- ORACLE (NCT06325020)
- Testing
- The assessment of patients with possible angina using the ORACLE pathway
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease, Stable Angina
Detection of Coronary Vulnerable Plaque With Contrast-enhanced Magnetic Resonance Imaging
MRI has the ability to visualize the arterial vessel wall. Wall thickening and atherosclerotic plaque components can be visualized in the carotid arteries and the aorta.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina
- Trial name
- T9M (NCT00984776)
- Testing
- Contrast enhanced MRI with Gadofosveset
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Stable Angina Pectoris Associated With Depression
The Efficacy and Safety of Ginkgo Biloba Dropping Pills in the Treatment of Coronary Heart Disease With Stable Angina Pectoris and Depression
To evaluate the clinical efficacy of Ginkgo biloba dropping pills on improving the frequency of angina pectoris and the life quality of patients with stable angina pectoris and depression symptoms on the basis of the best western…
- Trial name
- NCT04529148
- Testing
- Ginkgo biloba dropping pills，best western medicine treatment, Mimetic drug of ginkgo biloba dropping pills，best western medicine treatment
- Where
- 4 sites in China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Wanbangde Pharmaceutical Group Co., LTD
Angina (Stable), Chest Pain Atypical Syndrome
The Use of Artificial Intelligence-Enhanced Electrocardiograms in the Chest Pain Clinic to Risk Stratify Patients, Provide Rapid Reassurance and Enable a Low-Cost Clinical Pathway
Our current pathway for investigating patients with chest pain differs depending on if the pain is cardiac sounding or not. National guidelines advise us that patients with non-cardiac chest pain do not need further tests beyond…
- Trial name
- NCT07757425
- Testing
- AI-ECG
- Where
- 2 sites in United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- Jamil Mayet
Stable Chronic Angina
Ticagrelor vs. Clopidogrel in Post PCI Patients
Elective PCI were included in the study. Patients were randomized into two different groups. One group took ASA 80 mg once daily and clopidogrel 75 mg once a day, and the other one took ASA 80 mg once a day and ticagrelor 90 mg…
- Trial name
- NCT05858918
- Testing
- Clopidogrel, Ticagrelor
- Where
- Iran
- Volunteers
- 476 people
- Sponsor
- Shiraz University of Medical Sciences
Coronary Artery Disease
Prasugrel/Clopidogrel Maintenance Dose Washout Study
The primary objective of the study is to describe the cumulative proportion of participants who return to baseline platelet P2Y12 receptor function over time (up to 12 days post last maintenance dose) following discontinuation of…
- Trial name
- NCT01014624
- Testing
- Prasugrel, Clopidogrel
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Daiichi Sankyo
Chronic Coronary Syndrome, Stable Angina
Effectiveness and Tolerability of Trimetazidine 80mg Once Daily in Patients With Chronic Coronary Syndrome: The V-GOOD Study
The objective of this non-interventional multicentric study (NIS) is to investigate the efficacy and tolerability of treatment with Vastarel Caps LP® in symptomatic patients with angina over 3 months under conditions of daily…
- Trial name
- V-GOOD (NCT06464276)
- Testing
- No intervention
- Where
- Brazil
- Volunteers
- 800 people
- Sponsor
- Ministry of Health, Brazil
Coronary Disease, Heart Diseases
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- PIV-EPIC (NCT06535568)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Coronary Heart Disease, Chronic Kidney Disease
Prevalence of Chronic Kidney Disease and Its Association With Clinical Outcome in Patients With Coronary Heart Disease
This is a prospective, multi-center, hospital-based observational study. The aim of the study is to evaluate the prevalence of chronic kidney disease in patients with stable coronar heart disease.
- Trial name
- NCT02509013
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University First Hospital
Atrial Fibrillation, Cerebrovascular Accident
Comparing the Effects of Amiodarone, Sotalol, and Placebo in Maintaining Sinus Rhythm in Patients With Atrial Fibrillation Converted to Sinus Rhythm
Atrial fibrillation is the most frequently occurring cardiac arrhythmia, with 1.0-1.5 million cases annually. It is a risk factor for congestive heart failure, and stroke, 75,000 cases of the latter occurring annually in patients…
- Conditions
- Atrial Fibrillation, Cerebrovascular Accident, Death, Sudden
- Trial name
- NCT00007605
- Testing
- Amiodarone, Sotalol
- Where
- 28 sites in United States
- Volunteers
- 706 people
- Sponsor
- US Department of Veterans Affairs
Ischemic Heart Disease
Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler
The purpose of this study is to evaluate the efficacy and tolerance of a dipyridamole/adenosine combination given intravenously, as a slow bolus and at low doses to adenosine alone (given at its recommended dosage adjusted to…
- Trial name
- NCT01593644
- Testing
- adenosine + dipyridamole
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Adenobio N.V
Coronary Syndrome
Medical Evaluation of Scanner in Coronary Syndrome
Many recent publications have reported encouraging results on diagnostic cardiac multislice CT performance in 1) coronary artery disease, 2) coronary arterial bypass graft potency and 3) intrastent restenosis.
- Trial name
- EVASCAN (NCT00709709)
- Testing
- multislice coronary scan
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stable Angina
Efficacy and Safety of Monocordil Manufactured by Laboratórios Baldacci
Phase III clinical study for the evaluation of clinic and cardiologic effects of isosorbide mononitrate from the incidence of events (angina episodes). This is an open, comparative, monocentric trial.
- Trial name
- NCT02152579
- Testing
- Isosorbide-5-mononitrate
- Where
- Brazil
- Volunteers
- 86 people
- Sponsor
- Laboratórios Baldacci S.A
Stable Ischemic Heart Disease, Coronary Artery Disease
De-Adoption of Beta-Blockers in Patients With Stable Ischemic Heart Disease
Patients with heart disease are often prescribed many medications and these patients may experience drug interactions or negative drug related side effects.
- Conditions
- Stable Ischemic Heart Disease, Coronary Artery Disease, Beta-blocker Therapy
- Trial name
- ABBREVIATE (NCT05081999)
- Testing
- Medical Assessment, Quality of Life Assessment
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- University of Alberta
Coronary Artery Disease
High Clopidogrel Dose Versus Prasugrel and Ticagrelor in High Reactive Stable Patients
Dual antiplatelet therapy with Aspirin and Clopidogrel for at least one year is essential in patients following an acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) with drug eluting stent(s) implantation.
- Trial name
- TRIPLETE RESET (NCT01543932)
- Testing
- Clopidogrel, Prasugrel, Ticagrelor
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease
Ranolazine Loading to Prevent PCI-induced Myocardial Injury
It has previously been shown that pretreatment with ranolazine 1,000 mg twice daily for 7 days can significantly reduce procedural myocardial injury in elective percutaneous coronary intervention (PCI).
- Trial name
- TWILIGHT (NCT01491061)
- Testing
- Ranolazine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Heart Failure With Reduced Ejection Fraction, Dilated Cardiomyopathy
v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491
The purpose of this Phase 1b/2a study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MYK-491 in patients with stable heart failure.
- Trial name
- NCT03447990
- Testing
- MYK-491
- Where
- 17 sites in United States, France and 5 more
- Volunteers
- 52 people
- Sponsor
- Bristol-Myers Squibb
Coronary Artery Disease, Pneumonia Nosocomial
Nosocomial Pneumonia After Coronary Artery Bypass Grafting
Observational studies of patients with coronary artery bypass grafting, associated with an unfavorable cardiopulmonary prognosis for at least one year after surgery.
- Trial name
- CABG-PNEUM (NCT07476274)
- Testing
- Clinical, laboratory, and instrumental examination
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Stable Coronary Artery Disease Undergoing PCI
Rosuvastatin for Reduction of Myocardial Damage and Systemic Inflammation During Coronary Angioplasty
Myocardial necrosis is relatively frequent after percutaneous coronary intervention and is associated with higher mortality during the follow-up.
- Trial name
- REMEDY (NCT02205775)
- Testing
- Atorvastatin, Rosuvastatin, Ezetimibe
- Where
- 6 sites in Italy
- Volunteers
- 280 people
- Sponsor
- G. d'Annunzio University
Coronary Artery Disease
Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease
The primary hypothesis is that computed tomography (CT) is superior to invasive coronary angiography (ICA) concerning the primary endpoint MACE (MACE = major adverse cardiovascular event; defined as at least one of the following…
- Trial name
- DISCHARGE (NCT02400229)
- Testing
- Computed tomography angiography (cardiac CT), Invasive coronary angiography (ICA)
- Where
- 20 sites in Austria, Czechia and 13 more
- Volunteers
- 3,546 people
- Sponsor
- Charite University, Berlin, Germany