Clinical trials: Stable Ischemic Heart Disease
Angina Pectoris, Coronary Artery Disease
Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina
This study will evaluate the effect of ranolazine compared to placebo on the average weekly angina frequency in subjects with chronic stable angina and coronary artery disease (CAD) who have a history of type 2 diabetes mellitus…
- Conditions
- Angina Pectoris, Coronary Artery Disease, Type 2 Diabetes Mellitus
- Trial name
- TERISA (NCT01425359)
- Testing
- Ranolazine
- Where
- 135 sites in United States, Belarus and 12 more
- Volunteers
- 949 people
- Sponsor
- Gilead Sciences
Stable Angina, Acute Coronary Syndrome
Novasight Hybrid Intravascular Ultrasound and Optical Coherence Tomography System (IVUS OCT)
Collection of coronary images with a hybrid IVUS OCT system.
- Trial name
- NCT03484975
- Testing
- Observation group
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Conavi
Ischemic Heart Disease
Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes
The mainstay for treatment for acute coronary syndrome (ACS) focusses on re-establishing and maintaining the patency of vessels following coronary plaque disruption, through the use of anti-platelets and anticoagulants.
- Trial name
- LILACS (NCT03113773)
- Testing
- Proleukin
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Angina (Stable), Coronary Occlusion
Drug-Coated Balloon Only Strategy After Recanalization of Chronic Total Coronary Occlusions
Chronic total occlusions (CTO) of the coronary arteries are usually treated with drug-eluting stents (DES) after successful recanalization.
- Conditions
- Angina (Stable), Coronary Occlusion, Coronary Artery Disease, Chronic Total Occlusion
- Trial name
- NoTrace-CTO (NCT07817719)
- Testing
- Paclitaxel-coated balloon (AGENT Paclitaxel-Coated PTCA Balloon Catheter), Serial intravascular ultrasound and protocol-mandated nine-month angiographic reassessment
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo General Hospital
Atherosclerosis, Coronary Artery Disease
Imaging and Biomarkers of Atherosclerosis in Patients With Stable or Unstable Coronary Artery Disease
In this study, multimodal imaging of atherosclerosis and dosage of new circulating biomarkers will be used to compare patients with stable or unstable coronary artery disease
- Conditions
- Atherosclerosis, Coronary Artery Disease, Acute Coronary Syndrome
- Trial name
- BIOCORE-2 (NCT01186666)
- Testing
- Coronary intervention using IVUS-VH & FDG PET-MDCT
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Angina, Stable, Inflammation
The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris
This is a randomized, double-blind, placebo-controlled, adaptive clinical trial, which will assess the effect of DanshenDuofensuanyan[Danshen (a kind of Chinese herbal drug) extract] treatment on Lipoprotein associated…
- Trial name
- DOLPHIN (NCT02870764)
- Testing
- Dan-shen extract, Standard medical care
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Taizhou Fourth People's Hospital
Stable Angina
Downstream Molecular Signals of P2Y12 Receptors in Hyporeactive Patients Under Clopidogrel Treatment A Possible Mechanism of HOTPR(High On-Treatment Platelet Reactivity)
The investigators designed the following experiment to observe the pattern of administration in vitro, which can be completely excluded liver enzyme cytochrome P450 metabolism under the influence and observe the relevant P2Y12…
- Trial name
- NCT03190005
- Testing
- clopidogrel
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Taipei City Hospital
Treatment Decision, Coronary Artery Disease
CT Myocardial Perfusion to Guide the Diagnosis and Treatment of Patients With Stable Coronary Artery Disease (POTENTIAL)
The overall goal of this project is to compare the non-revascularization rate of coronary angiography in patients with stable coronary artery disease (CAD) within 90 days after CT myocardial perfusion imaging (CT-MPI) or…
- Trial name
- NCT06119022
- Testing
- Invasive coronary angiography, routine medical treatment
- Where
- 4 sites in China
- Volunteers
- 660 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Coronary Artery Disease
Peg-Granulocyte-Colony Stimulating Factor (GCSF) for Coronary Collateral Growth in Coronary Artery Disease Patients
The purpose of this study in patients with stable coronary artery disease (CAD) treatable by PCI (percutaneous coronary intervention) is to evaluate the long-term efficacy and safety of subcutaneously applied, pegylated…
- Trial name
- NCT00886509
- Testing
- pegfilgrastim
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Angina Pectoris
The Effect of Exercise on Peripheral Blood Gene Expression in Angina
Regular exercise is known to produce significant health benefits and to reduce the risk of heart diseases, although how this benefit occurs is not well understood.
- Trial name
- NCT01147952
- Testing
- Structured exercise training
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Chronic Stable Angina
The Effects of Inorganic Nitrate on Cardiac Muscle in Angina
Previous studies have shown that interventions which modestly increase blood nitrite_ improve skeletal muscle function on exercise while sparing oxygen, and have been also shown to open up the blood flow during periods of oxygen…
- Trial name
- NCT02078921
- Testing
- Sodium Nitrate
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Aberdeen
Coronary Artery Disease (CAD), Stable Angina Pectoris
Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina
Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK.
- Conditions
- Coronary Artery Disease (CAD), Stable Angina Pectoris, Ischaemic Heart Disease (IHD)
- Trial name
- ILUMINA (NCT07864025)
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Stable Angina
COBRA SHIELD OCT Study
Phase one of this study is a prospective, randomized (2:1), pilot study that will evaluate COBRA PzF vascular healing patterns and thrombus formation with Optical Coherence Tomography (OCT) at 3 months after stent implantation in…
- Trial name
- NCT02224235
- Testing
- Aspirin, Resolute Integrity DES, COBRA PzF
- Where
- 2 sites in Finland
- Volunteers
- 8 people
- Sponsor
- CeloNova BioSciences, Inc.
Coronary Artery Disease, Prediabetic State
Effects of dapaglifloziN Therapy on Myocardial Perfusion Reserve in Prediabetic Patients With Stable coronarY Artery Disease
The purpose of this study is to investigate the effects of dapagliflozin therapy on myocardial perfusion reserve (MPR) using dynamic SPECT examination in prediabetic patients with stable CAD.
- Trial name
- NCT04330079
- Testing
- Dapagliflozin 10mg, Lifestyle modification
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Silent Myocardial Ischemia, Type 2 Diabetes
Does Ranolazine Decrease Biomarkers of Myocardial Damage in Diabetics
The purpose of this investigation is to compare subjects at high risk for silent myocardial ischemia in the placebo group to subjects at high risk for silent myocardial ischemia in the ranolazine group to determine if ranolazine…
- Trial name
- NCT02611596
- Testing
- Ranolazine
- Sponsor
- Walter Reed National Military Medical Center
Myocardial Ischemia, Ischemic Reperfusion Injury
Remote Ischemic Preconditioning in Elective Percutaneous Interventions
Myocardial injury occurs after percutaneous coronary intervention due to micro emboli, ischemia-reperfusion injury or side branch occlusion.
- Trial name
- NCT02581618
- Testing
- remote ischemic preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Trakya University
Atherosclerosis, Coronary Artery Disease
Clinical Trial for Dose Finding and Safety of RVX000222 in Subjects With Stable Coronary Artery Disease
The purpose of this study is to investigate dose range, safety and efficacy of RVX000222 in subjects with stable coronary artery disease.
- Trial name
- ASSERT (NCT01058018)
- Testing
- RVX000222
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Resverlogix Corp
Acute Coronary Syndromes, Stable Angina Pectoris
Angio-Seal® vs. Exo-Seal® for Closure of Arterial Puncture Sites
Background: Vascular closure devices (VCD) were developed to reduce access site bleedings, to improve patients´ comfort, and to accelerate ambulation after percutaneous coronary interventions (PCI).
- Trial name
- NCT01669382
- Testing
- percutaneous coronary intervention
- Where
- 3 sites in Germany
- Volunteers
- 304 people
- Sponsor
- University Hospital Erlangen
Stable Angina
Evaluation of Vascular Regeneration After a Drug Eluting Stent Implantation
This is a prospective cohort, one center. twenty patients who will undergo percutaneous stent implantation with everolimus eluting stent will be include. The primary endpoint was the correlation between the change (baseline vs.
- Trial name
- REVER (NCT03214900)
- Volunteers
- 20 people
- Sponsor
- Hospital San Carlos, Madrid
Coronary Artery Disease, Hypercholesterolemia
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
The main aim of this trial is to demonstrate that Evolocumab plus routine lipid management is superior to routine lipid management alone in modifying plaque (non-calcified) volume as measured by Artificial Intelligence-enabled…
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Atheroma, Atherosclerotic Plaque
- Trial name
- NCT07803679
- Testing
- Evolocumab, Routine Lipid Management, Autoinjector
- Volunteers
- 308 people
- Sponsor
- Amgen