Clinical trials: Stable Ischemic Heart Disease
Coronary Disease
CT Calcium Scoring in Suspected Stable Angina
Patients with stable chest pain presenting to general practitioners in UK are routinely referred to the chest pain clinics in the hospitals.
- Trial name
- NCT01660594
- Testing
- CT calcium scoring
- Where
- United Kingdom
- Volunteers
- 705 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Coronary Artery Disease, Plaque, Atherosclerotic
Coronary Artery Plaque Burden in Stable Angina and Non-obstructive Coronary Artery Disease
Non-obstructive coronary artery disease (CAD), particularly common in women, has been associated with impaired quality of life and risk of recurrent hospitalizations.
- Trial name
- NCT04009421
- Testing
- Coronary artery plaque assessment by CT coronary angiography QAngio CT RE
- Where
- Norway
- Volunteers
- 1,400 people
- Sponsor
- University of Bergen
Statin Dose
Effective Dose of Statin Post PCI
In this study post coronary stenting patients, were enrolled to receive moderate dose versus high dose statin for 1 year, and the result of major adverse cardiovascular events were recorded
- Trial name
- NCT04923152
- Testing
- moderate statin dose, high dose statin
- Where
- Iran
- Volunteers
- 582 people
- Sponsor
- Shiraz University of Medical Sciences
Coronary Heart Disease
A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome
This study will evaluate the potential of RO4607381 to reduce cardiovascular morbidity and mortality in stable coronary heart disease patients with recent Acute Coronary Syndrome (ACS) and evaluate the long term safety profile of…
- Trial name
- NCT00658515
- Testing
- Dalcetrapib (RO4607381), Evidence-based medical care for Acute Coronary Syndrome
- Where
- 1,089 sites in United States, Argentina and 27 more
- Volunteers
- 15,871 people
- Sponsor
- Hoffmann-La Roche
Stable Ischemic Heart Disease; Acute Coronary Syndrome; Myocardial Infarction; Myocardial Ischemia
Research on Diagnosis and Prognosis of Myocardial Ischemia Level Using Magnetocardiography
Magnetocardiography (MCG) is a non-invasive and accurate method of detecting myocardial ischemia. However, the previous MCG is limited in clinical practice due to its high working conditions and limited sensitivity.
- Trial name
- NCT05718206
- Testing
- Magnetocardiography
- Volunteers
- 146 people
- Sponsor
- Xiangya Hospital of Central South University
Coronary Artery Disease, Endothelial NO-synthase
Regulation and Signaling of Red Blood Cell (RBC) Endothelial Nitric Oxide Synthase (eNOS) in Patients With Stable and Unstable Coronary Artery Disease
The aim of this study is measurement of expression and activity of RBC eNOS in different clinical cohorts of patients with coronary artery disease and acute coronary syndrome and to investigate the importance of the NO-stimulated…
- Trial name
- NCT02265016
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Coronary Artery Disease, Stable Angina
Optimal Predilatation Treatment Before Implantation of a Magmaris Bioresorbable Scaffold in Coronary Artery Stenosis
The aim of the study is to investigate if lesion preparation with a ScoreFlex balloon compared to a standard non-compliant balloon improve vascular healing and minimize lumen reduction after implantation of a Magmaris…
- Conditions
- Coronary Artery Disease, Stable Angina, Coronary Artery Stenosis, Myocardial Infarction
- Trial name
- OPTIMIS (NCT04666584)
- Testing
- ScoreFlex balloon, Device: standard non-compliant balloon
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease, Angina (Stable)
Coronary Sinus Reducer Therapy for Persisting Angina
Refractory angina due to advanced obstructive coronary artery disease (CAD) remains a major clinical problem with limited evidence-based treatment options.
- Trial name
- REDUCE ANGINA (NCT07485985)
- Testing
- Coronary sinus reducer
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Coronary Disease
A Randomized Phase 1 Dose-Escalation Study of Subcutaneously(SC) Administered RUC-4
This study is designed to assess tolerability of the weight-adjusted dose of RUC-4 (mg/kg) required to achieve 80% or more inhibition of the initial slope of platelet aggregation to 20 µM ADP by Light Transmission Aggregometry…
- Trial name
- NCT03844191
- Testing
- RUC-4 Compound
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- CeleCor Therapeutics
Coronary Artery Disease
To Evaluate Safety, Pharmacokinetics and Pharmacodynamics of MEDI6012 in Subjects With Stable Coronary Artery Disease
This is a Phase 2a randomized, double-blind (subject/investigator blinded, MedImmune unblinded), placebo-controlled, dose-escalation study to evaluate the safety, PK/PD, and immunogenicity of single IV and SC MEDI6012 doses in…
- Trial name
- NCT02601560
- Testing
- MEDI6012
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- MedImmune LLC
Coronary Artery Disease, Stable Coronary Artery Disease
Cardiovascular Events Related to Treated Coronary Arteries in Stable Multivessel CAD
This retrospective cohort study evaluates cardiovascular events directly related to treated coronary arteries in patients with stable multivessel coronary artery disease.
- Conditions
- Coronary Artery Disease, Stable Coronary Artery Disease, Multivessel Coronary Artery Disease, Myocardial Ischemia
- Trial name
- NCT07362108
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Optimized Medical Therapy
- Volunteers
- 1,695 people
- Sponsor
- Instituto do Coracao
Abdominal Aortic Aneurysm, Acute Myocardial Infarction
Body Mass Index and Initial Presentations of Cardiovascular Diseases
The association between obesity and cardiovascular disease (CVD) has mostly been studied using broad endpoints or have focused on cause-specific mortality.
- Conditions
- Abdominal Aortic Aneurysm, Acute Myocardial Infarction, Stroke, Heart Failure
- Trial name
- CALIBER (NCT01704300)
- Where
- United Kingdom
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Progression of Atherosclerotic Plaque, Coronary Artery Disease
Coronary Chronic Total Occlusion and Oxidative Balance
The presence of chronic blockage of coronary arteries, which we may accept as the terminal point of atherosclerotic coronary artery disease, is closely associated with a poor prognosis.
- Trial name
- NCT04754880
- Testing
- Comparison of oxidative and antioxidative markers between groups
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Coronary Artery Disease
CTRP3 and Progranulin in Patients With Coronary Artery Disease
Visceral obesity is the one of the major causes of cardiovascular morbidity and mortality in industrialized countries. Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the…
- Trial name
- NCT01869816
- Where
- South Korea
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Korea University
Stable Angina Pectoris, Unstable Angina Pectoris
Feasibility Study of Photopheresis Post Angioplasty
The primary objective of the study is to evaluate the difference in 6-month restenosis rates in coronary artery lesions treated by photopheresis in addition to angioplasty with stent placement, as opposed to no photopheresis…
- Conditions
- Stable Angina Pectoris, Unstable Angina Pectoris, Silent Ischemia
- Trial name
- NCT00157001
- Testing
- Photopheresis Post Angioplasty
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Atlantic Health System
Stable Angina Pectoris, Unstable Angina Pectoris
PCB for Long De Novo Lesions of Main Coronary Arteries (D-Lesion Long Trial)
This study evaluates the Efficacy and Safety of Paclitaxel-Coated Balloon Catheter in Patients With Diffuse Long De Novo Lesions of Main Coronary Arteries.
- Trial name
- NCT03155971
- Testing
- Paclitaxel-Coated Balloon
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The People's Hospital of Liaoning Province
Coronary Artery Disease
Decisional Quality for Patients With Coronary Artery Disease
The objective of the DeQCAD study is to measure the quality of the decision-making process for patients with coronary artery disease (CAD) and Acute Coronary Syndrome (ACS) who are making treatment decisions.
- Trial name
- DeQCAD (NCT02145481)
- Testing
- Decision Aid, CAD Education
- Where
- 4 sites in United States
- Volunteers
- 677 people
- Sponsor
- University of California, San Francisco
Angina Pectoris
Efficacy and Safety of Lacidipine in Chronic Stable Angina
The aim of this study was to explore whether lacidipine at doses of 2 mg, 4 mg and 6 mg decreased the symptoms of angina, compared to placebo in patients with chronic stable angina
- Trial name
- NCT02232607
- Testing
- Lacidipine, low dose, Lacidipine, medium dose, Lacidipine, high dose
- Volunteers
- 283 people
- Sponsor
- Boehringer Ingelheim
Atherosclerosis, Stroke
Vascular Inflammation Imaging Using Somatostatin Receptor Positron Emission Tomography
This VISION study aims to investigate the role of inflammation in atherosclerosis using 68Ga- DOTATATE PET, and to validate 68Ga-DOTATATE PET imaging for the detection and quantification of vascular inflammation in the aorta…
- Conditions
- Atherosclerosis, Stroke, Transient Ischemic Attack, Chronic Stable Angina
- Trial name
- VISION (NCT02021188)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Cambridge
Coronary Artery Disease
Functional Assessment by Virtual Online Reconstruction. The FAVOR III Europe Trial
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is estimated based on two angiographic projections.
- Trial name
- NCT03729739
- Testing
- QFR-based diagnostic strategy, FFR-based diagnostic strategy
- Where
- 35 sites in Denmark, France and 9 more
- Volunteers
- 2,001 people
- Sponsor
- Aarhus University Hospital Skejby