Clinical trials: Stage 0 Breast Cancer
DCIS, Stage 0 Breast Cancer
The PREDICT Registry:
This is a prospective, non-interventional (observational) cohort study conducted within the medical network of the participating investigators and institutions.
- Conditions
- DCIS, Stage 0 Breast Cancer, Ductal Breast Carcinoma In Situ
- Trial name
- NCT03448926
- Testing
- Treatment recommendation surveys, 7-gene biosignature
- Where
- 30 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- PreludeDx
Breast Cancer, Ductal Carcinoma in Situ
Phase IV Trial to Evaluate Breast Brachytherapy Using the Mammosite-Ml®
This study will evaluate the local control rate, cosmetic results, and complication rates of breast brachytherapy delivered using the MammoSite-ML® when used as the sole method of radiation therapy or as a boost technique for…
- Trial name
- Mammosite ML (NCT01448447)
- Testing
- Mammosite ML
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mercy Research
Breast Cancer
Radiation Therapy Planning Techniques in Reducing Damage to Normal Tissue in Women Undergoing Breast-Conserving Surgery for Ductal Carcinoma of the Breast
RATIONALE: Diagnostic procedures, such as multifunctional magnetic resonance imaging and CT scans, may help reduce normal tissue damage in patients undergoing radiation therapy for cancer.
- Trial name
- NCT00602628
- Testing
- questionnaire administration, adjuvant therapy, biopsy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Ductal Breast Carcinoma In Situ, Invasive Breast Carcinoma
Effects of Chemotherapy on Intestinal Bacteria in Patients With Newly Diagnosed Breast Cancer
This pilot research trial studies the effects of chemotherapy on intestinal bacteria/organisms (microbiota) in patients newly diagnosed with breast cancer.
- Conditions
- Ductal Breast Carcinoma In Situ, Invasive Breast Carcinoma, Stage I Breast Cancer, Stage IIA Breast Cancer
- Trial name
- NCT02370277
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Southern California
Breast Cancer
Targeted Intra-Operative Radiotherapy for the Management of Ductal Carcinoma In-Situ of the Breast
We hypothesize that the combination of mammography and CE-MRI will improve the surgeon and radiologist's ability to define extent of disease prior to surgical resection, improve the odds of obtaining clear surgical margins, and…
- Trial name
- NCT00556907
- Testing
- Intraoperative radiotherapy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Southern California
Stage 0/1 Breast Cancer, Post Biopsy
Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer
NAC is the N-acetyl derivative of the naturally occurring amino acid, L-cysteine. It is a common over-the-counter supplement and also is available as an injectable pharmaceutical that protects the liver in cases of acetaminophen…
- Conditions
- Stage 0/1 Breast Cancer, Post Biopsy, Pre-surgery
- Trial name
- NAC (NCT01878695)
- Testing
- IV/oral n-acetylcysteine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Breast Cancer
Radiation Therapy Using Gold Markers in Treating Women With Early-Stage Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Placing gold markers in the area where the tumor was removed may help doctors better direct radiation therapy and help reduce the risk of cancer…
- Trial name
- NCT00749437
- Testing
- 3-dimensional conformal accelerated partial breast irradiation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Breast Cancer
Comparison of Biomarkers Based on Fine-Needle Aspiration in Women at Increased or Normal Risk of Breast Cancer
RATIONALE: Examining biomarkers in fine-needle aspiration specimens from women at risk for breast cancer may improve the ability to detect breast cancer cells early and plan effective treatment.
- Trial name
- NCT00041353
- Testing
- cytology specimen collection procedure, comparison of screening methods, study of high risk factors
- Sponsor
- Fox Chase Cancer Center
Breast Cancer Stage 0, Breast Cancer Stage I
Increasing Patients' Engagement in Breast Cancer Surgery Decision-Making
This trial studies how well a breast cancer surgery decision aid works in increasing patient engagement in decision making for patients with newly diagnosed stage 0-III breast cancer.
- Conditions
- Breast Cancer Stage 0, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III
- Trial name
- NCT03766009
- Testing
- Usual Care, Web-based decision aid
- Where
- 58 sites in United States, Guam and 1 more
- Volunteers
- 627 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Neoplasms
A Registry Study of Breast Microseed Treatment
For women diagnosed with early stage breast cancer, lumpectomy followed by radiation is a common treatment option. Radiation treatment is typically delivered to the whole breast, five times per week, for anywhere from 3 to 8…
- Trial name
- NCT02701244
- Testing
- Permanent Breast Seed Implant (PBSI)
- Where
- 3 sites in United States
- Volunteers
- 420 people
- Sponsor
- Concure Oncology-Breast Microseed Inc.
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Web-Based Symptom Monitoring and Self-Management Portal (YES) for Adolescent and Young Adult Breast Cancer Survivors
This clinical trial compares a web-based patient-reported symptom monitoring and self management portal, the Young, Empowered \& Strong (YES), to standard therapy in managing symptoms in adolescent and young adult breast cancer…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- YES (NCT04906200)
- Testing
- Best Practice, Internet-Based Intervention, Survey Administration
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer Screening, Breast Carcinoma in Situ
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
Most physicians still use a one-size-fits-all approach to breast screening in which all women, regardless of their personal history, family history or genetics (except BReast CAncer gene (BRCA) carriers) are recommended to have…
- Conditions
- Breast Cancer Screening, Breast Carcinoma in Situ, Breast Cancer
- Trial name
- WISDOM (NCT02620852)
- Testing
- Complete a health questionnaire, Provide a saliva sample for genetic testing, Screening advice based on a comprehensive risk assessment
- Where
- 11 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Breast Cancer, Invasive Breast Cancer
Genetic Testing for All Breast Cancer Patients (GET FACTS)
This study is designed to determine the impact of a novel genetic counseling method on surgical decisions in individuals with newly diagnosed breast cancer This research study involves an expedited and surgery-specific form of…
- Conditions
- Breast Cancer, Invasive Breast Cancer, in Situ Breast Cancer, Genetic Testing
- Trial name
- NCT04245176
- Testing
- Standard Genetic Counseling, Quantitative Genetic Counseling
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Breast Cancer, DCIS
Trial of Radiation Fractionation Schedules for Once-a-Day Accelerated Partial Breast Irradiation
This is a multi-centre randomized phase II trial in women with invasive carcinoma of the breast with negative axillary nodes or Ductal Carcinoma In-situ (DCIS) treated by Breast Conserving Surgery (BCS).
- Trial name
- OPAR (NCT02637024)
- Testing
- APBI: 30 Gy, APBI: 27.5 Gy
- Where
- 10 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Atypical Ductal Hyperplasia (ADH) of the Breast
Atypical Lesions of the Breast: Close Observation Versus Excision (ALCOVE)
This study is designed to look at whether it is feasible to observe women with atypical ductal hyperplasia (ADH) of the breast, or whether surgical excision is necessary.
- Trial name
- ALCOVE (NCT01925586)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Yale University
PDL1 Gene Mutation, Non Small Cell Lung Cancer
177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors
This is a Phase 0/1, First-in-Human (FIH), study to evaluate safety, tolerability, biodistribution, radiation dosimetry and preliminary anti-tumour activities of 177Lu-RAD204 in participants with selected solid tumours, to…
- Conditions
- PDL1 Gene Mutation, Non Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), TNBC, Triple Negative Breast Cancer
- Trial name
- NCT06305962
- Testing
- 177Lu-RAD204
- Where
- 5 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Radiopharm Theranostics, Ltd
Gastric Cancer, Invasive Breast Cancer
CONFIRM: Magnetic Resonance Guided Radiation Therapy
This research is being done to determine the safety and feasibility of using a type of radiation guided by magnetic resonance imaging (MRI) and chemotherapy to treat patients with gastric and breast cancer.
- Conditions
- Gastric Cancer, Invasive Breast Cancer, in Situ Breast Cancer, Mantle Cell Lymphoma
- Trial name
- CONFIRM (NCT04368702)
- Testing
- Viewray MRIdian® Linac
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Brigham and Women's Hospital
Breast Cancer, Fatigue
Infliximab in Treating Cancer-Related Fatigue in Postmenopausal Women Who Have Undergone Treatment for Breast Cancer
RATIONALE: Infliximab may help improve energy levels in patients who have undergone treatment for breast cancer. PURPOSE: This phase II trial is studying how well infliximab works in treating cancer-related fatigue in…
- Trial name
- NCT00112749
- Testing
- infliximab, Clinical Assessment, Self-report questionnaires
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Cancer
Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients
RATIONALE: Liposomal amphotericin B may be effective in controlling fever and granulocytopenia. It is not yet known which regimen of liposomal amphotericin B is more effective in treating cancer patients who have these…
- Trial name
- NCT00003938
- Testing
- liposomal amphotericin B
- Where
- 24 sites in Belgium, Czechia and 13 more
- Volunteers
- 115 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer, Ductal Carcinoma In Situ
Hong Kong Breast Cancer Study
Introduction: With population ageing and increasing Westernization breast cancer continues to be important health conditions among women in Hong Kong.
- Trial name
- NCT02889458
- Testing
- Not Provided
- Where
- 21 sites in Hong Kong
- Volunteers
- 7,000 people
- Sponsor
- The University of Hong Kong