Clinical trials: Stage III Periodontitis
Periodontitis
Adjunctive Subgingival Pomegranate Peel Extract Gel for Stage II-III Periodontitis
This randomized, triple-blind, placebo-controlled split-mouth clinical trial aims to evaluate the clinical and biochemical efficacy of subgingival pomegranate peel extract gel as an adjunct to scaling and root planing (SRP) in…
- Trial name
- POME-PERIO (NCT07725393)
- Testing
- Pomegranate Peel Extract Gel
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- gehad samy
Periodontitis Stage III
Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis
The goal of this clinical trial is to learn if a treatment called injectable platelet-rich fibrin (i-PRF) helps improve gum health in people with a type of gum disease called Stage 3 Grade B periodontitis.
- Trial name
- NCT07029035
- Testing
- İnjectable platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Diseases
GCF Levels of Chemokines in Periodontitis
This study aimed to determine CCL19/MIP3beta(β) and CCL20/MIP3alpha(α) in the gingival crevicular fluid (GCF) of the patients with different periodontitis phenotypes.
- Trial name
- NCT06291454
- Testing
- Routine periodontal examination
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ordu University
Periodontitis, Periodontitis Stage III
Alb-PRF as an Adjunct to Regenerative Periodontal Surgery
Periodontitis is characterized by the progressive destruction of tooth-supporting tissues and may lead to the formation of intrabony periodontal defects.
- Conditions
- Periodontitis, Periodontitis Stage III, Periodontal Intrabony Defects
- Trial name
- NCT07805317
- Testing
- Regenerative Periodontal Surgery With EDTA and Allogeneic Bone Graft, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Periodontitis (Stage 3)
Effects of the Adjunctive Use of Hyaluronic Acid-based Gel in the Surgical Periodontal Treatment of Periodontitis
This study aimed to assess the effect of Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent in surgical periodontal treatment on clinical parameters and cytokine levels (IL-6, IL-8, IL-10, IL-17A, TOS, and TAS) in…
- Trial name
- Periodontit (NCT06842511)
- Testing
- open flap debridement and Hyaluronic Acid-Based Gel application, open flap debridement
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Ordu University
Stage III Periodontitis
Full-Mouth vs. Quadrant-Wise Scaling and Root Planing: Clinical Effectiveness, Environmental Sustainability, and Patient-Reported Outcomes
This randomized clinical trial compares full-mouth and quadrant-wise scaling and root planing in patients with Stage III periodontitis.
- Trial name
- NCT07785115
- Testing
- Full-Mouth Scaling and Root Planing, Quadrant-Wise Scaling and Root Planing
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Selcuk University
Periodontitis (Stage 3)
Hydrolyzed Collagen As A Host Modulation Agent in Non-Surgical Periodontal Treatment
This study was planned on the basis of the hypothesis that 'food supplements containing collagen will support the clinical effectiveness of non-surgical periodontal therapy'.
- Trial name
- NCT07683741
- Testing
- Collagen hydrolyzed peptides
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hatice Yemenoglu
Periodontitis (Stage 3)
Assessment of Autogenous Dentin Graft in Treatment of Infra-bony Defect
The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.
- Trial name
- NCT05258006
- Testing
- Autogenous demineralized dentin nanoparticles
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- October 6 University
Periodontitis, Bruxism
Impact of Bruxism in the Outcome of Subgingival Instrumentation for the Management of Stage 2 and Stage 3 Periodontitis.
Bruxism is a multifaceted phenomenon that has been associated with several factors mediated by the central nervous system3. Bruxism is an umbrella term grouping different motor phenomenon.
- Trial name
- NCT05995431
- Testing
- scaling and root planing, Subgingival instrumentation
- Where
- India
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Diseases, Periodontal Inflammation
Oral and Systemic aMMP-8 in Periodontal Disease
Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health.
- Trial name
- NCT04268381
- Testing
- Biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontal Health, Periodontitis
Gingival Crevicular Fluid, Salivary, and Serum Biomarkers Levels in Periodontal Treatment
The present study aimed to assess the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF), saliva, and serum IL-26, IL-6, and IL-10 levels in stage III grade B periodontitis (SIII-GB-P) and C…
- Trial name
- NCT05395455
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis Stage III, Periodontitis Stage IV
Blood Glucose Screening in Patients With Advanced Periodontits: the Role of Specialist Periodontal Care in Identifying Hyperglycaemia and Supporting Patient Centered Treatment
Periodontitis is a chronic inflammatory disease and individuals with advanced periodontitis have an increased risk of hyperglycaemia.
- Conditions
- Periodontitis Stage III, Periodontitis Stage IV, Diabetes (DM), Prediabetes
- Trial name
- NCT07426224
- Testing
- Selective screening of blood glucose/HbA1c
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Folktandvården Stockholms län AB
Periodontal Disease, Periodontitis (Stage 3)
Evaluation of Wnt5a and LRP5 Levels in Serum and Saliva Samples and the Relationship Between Clinical Periodontal Parameters
Objectives: Wnt5a is a secreted Wnt ligand that plays an important role in cellular homeostasis. Wnt interaction with coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) induces the proliferation of osteoblasts…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Periodontitis Stage III
- Trial name
- NCT06933784
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara University
Periodontitis, Periodontitis (Stage 3)
Evaluation of Albumin Platelet-Rich Fibrin Following SRP in Patients With Periodontitis
The study aims to investigate whether application of albumin platelet-rich fibrin (Alb-PRF) into the gum pockets after scaling and root planing (SRP) can improve healing in patients with Stage III Grade B periodontitis.
- Trial name
- NCT07363135
- Testing
- Albumin platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Saglik Bilimleri Universitesi
hsCRP
Association Between Grade(B/C)of Stage III and IV Periodontitis and High Sensitivity C Reactive Protein Level in Serum and Oral Rinse Sample
According to 2017 World Workshop of Periodontology , the level of high sensitivity C reactive protein has been assumed to increase according to the grade of periodontitis, however, specific evidence regarding this is lacking at…
- Trial name
- NCT06997770
- Where
- India
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Stage II or Stage III Grade B Periodontitis
Evaluation of the Changes in Matrix Metalloproteinase-9 Levels With Salvadora Persica (Miswak) in Periodontal Fibroblasts and Gingival Crevicular Fluid in Patients With Periodontitis
The study is conducted to evaluate the invitro effect of Salvadora persica (miswak) extract on periodontal fibroblasts production of matrix metalloproteinase-9 (MMP-9) and prostaglandin E2 (PGE2) and correlating the results to…
- Trial name
- NCT07599397
- Testing
- Salvadora Persica Root, Toothbrushing
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Stress, Psychological, Periodontal Diseases
Effect of Stress on Periodontal Therapy (NPT)
Aim of this study: is to evaluate the influence of stress level on the response of non surgical periodontal therapy in patients affected by severe periodontitis divided into "Medium/High stress level" or "Low stress level" based…
- Conditions
- Stress, Psychological, Periodontal Diseases, Periodontitis, Non Surgical Periodontal Therapy
- Trial name
- NCT04739475
- Testing
- Non Surgical Periodontal Therapy
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- University of Turin, Italy
Chronic Periodontitis
Utilization of a Videoscope in Periodontal Regeneration
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS).
- Trial name
- NCT05275192
- Testing
- Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery, Guided tissue regeneration surgery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Periodontal Pocket, Periodontitis
Multicenter Study on the Use of a Collagen-based Hydrogel for the Treatment of 153 Periodontal Pockets in 38 Adults With Generalized Stage III Periodontitis
This is a prospective, observational, multicenter study designed to evaluate the real-world efficacy and safety of H42®, a collagen hydrogel, in the treatment of periodontal pockets.
- Trial name
- NCT07592377
- Testing
- H42® Collagen Hydrogel for the non-surgical treatment of periodontal pockets
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Bioteck S.p.A.
Periodontal Diseases
Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases
The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.
- Trial name
- NCT05281796
- Testing
- GCF obtaining, saliva obtaining
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University