Clinical trials: Stage III Periodontitis
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis
Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis
The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control…
- Trial name
- GBT (NCT06726902)
- Testing
- GBT and SI with erythritol powder, GBT and SI with glycine powder, GBT and SI with trehalose powder
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Diana Ibrahim
Periodontitis
IL-10, IL-12 and IL-18 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls
Periodontitis is a multifactorial chronic inflammatory disease characterized by the destruction of the tissues supporting the tooth.
- Trial name
- NCT05307068
- Testing
- No intervention was applied to the groups the samples will be collected in terms of the diagnosis ( periodontitis, healthy)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Smoking Reduction
Cathelicidin LL-37 Levels in the GCF and the Saliva of Smokers and Non-smokers With Stage III,IV Periodontitis
Periodontitis is considered an inflammatory disease that results in the disruption of oral hemeostasis and is associated with the presence of dental plaque influenced by genetic and environmental factors.
- Trial name
- NCT04861493
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Periodontitis
Nd:YAG Laser Effects on Subgingival Microbiota in Stage III-IV Periodontitis
This randomized controlled trial (RCT) aims to evaluate the clinical efficacy of Nd:YAG laser adjunctive therapy and its impact on the subgingival microbiome in patients with stage III-IV periodontitis.
- Trial name
- NCT07061756
- Testing
- SRP, ND
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rui He
Periodontitis, Periodontitis Stage III
Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers
This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser.
- Conditions
- Periodontitis, Periodontitis Stage III, Periodontal Disease, Diode Laser Therapy
- Trial name
- NCT07213752
- Testing
- Diode Laser Application in Deep Periodontal Pockets, Professional Mechanical Plaque Removal, Scaling and Root Planing
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Obesity, Periodontal Diseases
Gingival Crevicular Fluid Levels of Prolactin Hormone in Obese Patients With Stage ii and Iii Periodontitis Before and After Non-surgical Periodontal Therapy
Obesity and periodontitis are among the most common chronic disorders affecting the world population, while Prolactin (PRL) is a neuroendocrine hormone that within the physiological range stimulates bone formation while mild to…
- Trial name
- NCT07571850
- Testing
- Obese patients with stage II and III periodontitis and non surgical peridontal therapy, obese patients with healthy periodontium with no intervention
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Periodontitis (Stage 3)
Autogenous Periosteal Pedicle Graft Versus Pericardium Membrane in Management of Periodontal Intrabony Defects in Stage III Periodontitis
The aim of this study is to compare between autogenous PPG and Pericardium membrane in management of periodontal intrabody defects in stage III periodontitis.
- Trial name
- NCT07111533
- Testing
- Open Flap Debridement (OFD), Bone Graft, Autogenous Periosteal Pedicle Graft (PPG)
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Minia University
Periodontis, Atherosclerosis Cardiovascular Disease
Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study
Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses.
- Trial name
- PAROCAR (NCT07263113)
- Testing
- Periodontal examination and pulse wave velocity
- Where
- France
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Periodontitis, Periodontitis and Treatment Need
Dental Loupe Versus Dental Operating Microscope for Non-Surgical Periodontal Treatment
Periodontitis is a multifactorial, non-infectious disease that can lead to tooth loss if left untreated. Advanced stages of periodontitis can affect chewing ability, nutritional status, and quality of life.
- Conditions
- Periodontitis, Periodontitis and Treatment Need, Periodontal Disease, Periodontal Pocket
- Trial name
- NCT07822269
- Testing
- Mechanical debridement and dental plaque sample collection with dental loupe, Mechanical debridement and dental plaque sample collection with dental microscope
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontitis, Dysbiosis
Gut Microbial Changes After Periodontal Treatment
Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients.
- Conditions
- Periodontitis, Dysbiosis, Intestinal Disease
- Trial name
- NCT04982302
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- University of Turin, Italy
Periodontal Pocket
Comparing Photodisinfection of Chitosan NP Enriched ICG Over ICG as Adjunct to OFD: RCT
The current study is a prospective randomised study-Comparison of photodisinfection with chitosan nanoparticles enriched indocyanine green over indocyanine green as an adjunct to open flap debridement in the management of stage…
- Trial name
- NCT06523244
- Testing
- PHOTODYNAMIC THERAPY
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Diseases
The Effects of Diode Laser as an Adjunct to Non-surgical Periodontal Treatment on Periodontal Status in Patients With Stage III-IV Periodontitis
Periodontal disease is serious and global chronic disease. The prevalence of periodontal diseases in United Arab Emirates is not clear but data from Dubai Health Authority showed that one in five patients has received periodontal…
- Trial name
- NCT04477551
- Testing
- Diode laser (device) with scaling and root planing, Conventional scaling and root planing
- Where
- United Arab Emirates
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
Periodontal Disease, Periodontitis (Stage 3)
Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis
Objectives: The aim of this study was to determine the changes in LRP5 and TPH1 levels in serum and saliva samples due to periodontal inflammation and to evaluate the relationship between these values and clinical periodontal…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Periodontitis Stage III
- Trial name
- NCT06933797
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara University
Periodontal Disease, Stage III Periodontitis
Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients
the aim of this study is to investigate the clinical outcomes of Minimally Invasive Non-Surgical Therapy(MINST) compared to Conventional non-surgical periodontal therapy (CNST)
- Trial name
- NCT07671274
- Testing
- Mechanical debridement ., minimally invasive mechanical debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Stage III Periodontitis
Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis.
Periodontitis is a chronic multifactorial inflammatory disorder affecting the periodontium, often implicated with microbial dysbiosis.
- Trial name
- NCT07859358
- Testing
- Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Sterile 0.9% Saline Solution
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
Peridontal Disease
Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy
This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects.
- Trial name
- NCT06789458
- Testing
- Professional mechanical plaque control
- Where
- 2 sites in Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Clinical Evaluation of Injectable Alb-PRF in the Management of Intrabony Defect in Stage-III Periodontitis Patients
Clinical Evaluation of Injectable Albumin Platelet Rich Fibrin Versus Platelet Rich Fibrin in the Management of Intra-bony Defect in Stage-III Periodontitis Patients.
- Trial name
- NCT06297577
- Testing
- Albumin Platelet Rich Fibrin (Alb-PRF) combined with minimally invasive surgical technique (MIST), Minimally invasive surgical technique (MIST)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Treatment Adherence
I-Smads in Periodontitis
Recently, it has been stated that Smads play an active role in all conditions where transforming growth factor-beta (TGF-β) is involved, including periodontal inflammation.
- Trial name
- NCT04846166
- Testing
- Periodontally healthy group, Periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontal Disease, AVDC Stage 3
Melatonin Gel as an Adjuvant in the Surgical Management of Intrabony Defects
Surgical periodontal therapy is a commonly employed treatment approach aimed at arresting disease progression and promoting tissue regeneration.
- Trial name
- NCT06821425
- Testing
- Melatonin gel mixed with xenograft, Xenograft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University