Clinical trials: Staining
Black Stains
Black Stains' Epidemiology, Clinical Evaluation and Dietary Habits: a Clinical Trial.
The aim of this study is to investigate epidemiology and treatment possibilities of black stains, with the assessment of a possible correlation with patients' dietary habits. Patients will be randomly divided into three groups.
- Trial name
- NCT04865796
- Testing
- Lactoferrin products, Probiotics products, Standard home oral care
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Pavia
Evaluation of Corneal Stability Post-applanation
Icare Tonometry Effects on Keratometry Readings, Topography Readings, and Corneal Staining
To demonstrate that the Icare tonometer does not alter Keratometry readings, topography, or corneal staining. This would therefore allow intraocular pressure (IOP) testing to be done at any time during an exam, without affecting…
- Trial name
- NCT03275142
- Testing
- Icare tonometer
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Comprehensive EyeCare of Central Ohio
Keratoconjunctivitis Sicca
A Phase 4 Study Investigating the Efficacy of Retaine™ in Managing Signs and Symptoms Associated With Dry Eye Syndrome
This study will evaluate the efficacy of Retaine™ ophthalmic emulsion in treating the signs and symptoms of dry eye syndrome.
- Trial name
- NCT02139033
- Testing
- Retaine™
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Ocusoft, Inc.
Pancreatic Disease
Endoscopic Ultrasound-guided Fine-needle Aspiration of Solid Pancreatic Lesions With Rapid Staining of Cytological Smears Followed by Whole Slide Scanning and Artificial Intelligence Diagnosis: A Prospective, Multicenter Study.
The objective of this observational study is to investigate whether the self-developed whole slide scanning and artificial intelligence diagnostic system for pancreatic solid lesion puncture cytopathology (hereinafter referred to…
- Trial name
- NCT06824909
- Testing
- ROSE-AI diagnostic system
- Where
- 2 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Ruijin Hospital
Irritable Bowel Syndrome, Digestive System Diseases
Abnormal Expression Proteins, Mitochondrial DNA and miRNA of Irritable Bowel Syndrome
In the investigators study, the investigators will focus on the screening of the related proteins and miRNA to IBS in order to reveal the possible clues or molecular mechanism for this disorder.
- Conditions
- Irritable Bowel Syndrome, Digestive System Diseases, Gastrointestinal Diseases, Intestinal Diseases
- Trial name
- IBS (NCT01028898)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Dental Calculus, Tooth Discoloration
Staining and Calculus Formation After 0.12% Chlorhexidine Rinses
The presence of plaque on tooth surfaces as a predictor of chlorhexidine side effects has not been evaluated especially because most studies utilized a previous disruption of biofilms in all dental surfaces before the beginning…
- Trial name
- NCT00818376
- Testing
- Dental prophylaxis
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lutheran University of Brazil
Port-Wine Stain
Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain
This study is to provide safety information of hemoporfin during the post-marketing period as required by China Food and Drug Administration (CFDA) regulations in order to identify any potential drug related treatment factors in…
- Trial name
- NCT03181984
- Testing
- Hemoporfin
- Where
- 7 sites in China
- Volunteers
- 501 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Esthetic Restorations
Effect of One-step Versus Multistep Polishing Protocol on Class IV Composite Restorations.
This study aims to evaluate the effectiveness of various finishing and polishing techniques for composite resins used in dental restorations, with a focus on minimizing discoloration and surface roughness over time.
- Trial name
- NCT06732115
- Testing
- One-step polishing system with nanohybrid resin composite restorations., Multistep system polishing system Super-Snap X-treme (Shofu) with nanohybrid resin composite restorations.
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vascular Stains
Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography
The purpose of this research study is to develop a better understanding of vascular stains and to improve the usual laser treatment for vascular stain by using optical coherence tomography (OCT).
- Trial name
- NCT04772911
- Testing
- Optical Coherence Tomography (OCT)
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- University of Wisconsin, Madison
Dental Caries in Children
Efficacy of Silver Diamine Fluoride and Its Parental Perception
This randomized clinical trial aims to compare the effectiveness of two topical fluoride application protocols, namely 38% silver diamine fluoride and sodium fluoride with added casein phosphopeptide-amorphous calcium phosphate…
- Trial name
- NCT04213573
- Testing
- silver diamine fluoride, MI Varnish
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Adverse Effect
Anti-staining Efficacy of Anti-Discoloration System (ADS) Added to Chlorhexidine (CHX)
Dental staining is the most common local side effect of chlorhexidine (CHX) mouthwashes. A prospective, cross-over, randomized clinical trial will be carried out in triple blind to compare the effect on dental staining of two…
- Trial name
- CHX+ADS (NCT02709824)
- Testing
- Chlorhexidine gluconate with ADS, Chlorhexidine gluconate without ADS
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Milan
Endometrial Cancer
P53 Immunohistochemistry Abnormal Staining in Endometrial Cancer
Objective: Calculate the incidence of P53 immunohistochemistry abnormal staining in endometrial cancer and to identify its relation with disease stages, pathological types and grading.
- Trial name
- NCT05542940
- Testing
- p 53 immunohistochemistry positive staining and relation to stages ,pathological types and grading
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Hossam Hassan Aly Hassan El Sokkary
Black Stains
Investigating the Bactericidal Effect of Probiotics on Chromogenic Bacteria in Children An In Vivo and In Vitro Study
To investigate the bactericidal effect of probiotics (Streptococcus salivarius M18 and Lactobacillus reuteri) on two types of bacteria (Aggregatibacter actinomycetemcomitans and Actinomyces naeslundii) causing black stains of…
- Trial name
- NCT06834815
- Testing
- Probiotic with Prebiotic
- Where
- Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Corneal Epithelial Disruption, Corneal Staining
Evaluation of Corneal Staining With Various Contact Lens/Solution Combinations
The purpose of this study is to quantify the amount of corneal staining observed with various marketed contact lens/multipurpose solution combinations.
- Trial name
- NCT00381446
- Testing
- Marketed contact lens care products
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Andrasko, Gary, OD, LLC
Gastrointestinal Neoplasms, Abnormality of Enteric Nervous System Morphology
Endoscopic Vital Nerve Staining in Gastrointestinal Diseases
In this study, methylene blue (MB) was used as vital nerve staining agent. During gastroenteroscopy, mucosal nerve staining was achieved by endoscopic submucosal injection of MB solution.
- Trial name
- NCT05232357
- Testing
- Sodium thiosulfate and Methylene blue solution
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Telehealth , Lipid Lowering Medication Adherence
Telenhealth and Adherence to Stains
To evaluate the effect of telehealth through short messaging services (SMSs) on adherence to statins in patients with diabetes.
- Trial name
- NCT05872919
- Testing
- SMS reminder massages about adherence
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Whitening
Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing.
The aim of this study is to evaluate and compare the immediate efficacy of a hydrogen peroxide-containing toothpaste versus a regular fluoride toothpaste without hydrogen peroxide in removing extrinsic tooth stains following a…
- Trial name
- NCT07276672
- Testing
- Optic White Adv Sparkling White (2%HP) Toothpaste, Colgate Great Regular Flavor Toothpaste
- Where
- Dominican Republic
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Breast Cancer
PD0332991/Paclitaxel in Advanced Breast Cancer
This study is a phase I, single arm, open-label trial of PD0332991 in combination with Paclitaxel in patients with Rb-expressing metastatic breast cancer.
- Trial name
- NCT01320592
- Testing
- PD0332991, Paclitaxel
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Contact Lens Wear
Compliance and Contamination in Soft Contact Lens Wearers
The purpose of this study is to assess the lens and lens case microbial colonization associated with marketed care solutions used by experienced soft lens wearers.
- Trial name
- NCT01069237
- Testing
- OPTI-FREE RepleniSH, Clear Care
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Amyloidosis
Application of High Resolution Optical Coherence Tomography in Skin Disease: Amyloidosis and Differential Diagnosis
Amyloidosis is caused by the misfolding protein accumulated in tissue, which affects the function of the organs. In addition to the primary cutaneous amyloidosis, a skin lesion may also appear in another classification - systemic…
- Trial name
- NCT04068077
- Testing
- ApolloVue™ S100 image system, Viper1-S003
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan