Clinical trials: Staining
Port Wine Stain
Combining Topical Imiquimod 5% Cream With a Pulsed Dye Laser to Treat Port Wine Stain Birthmarks
Port wine stains are red birthmarks that without treatment persist for a lifetime. They are frequently found on the face and can be conspicuous and disfiguring, negatively impacting social interactions for these patients.
- Trial name
- Aldara (NCT00585247)
- Testing
- Imiquimod
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Irvine
c-MET Positive Gastric Cancer
A Pilot Study of Crizotinib in Patients With c-MET Positive Gastric Adenocarcinoma as a Third-line Chemotherapy
This is a pilot study of crizotinib in patients with c-MET positive gastric adenocarcinoma.
- Trial name
- NCT02435108
- Testing
- crizotinib
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Samsung Medical Center
Cataract
Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsule
Effectiveness of lutein, zeaxanthin and trypan blue to stain the anterior lens capsule during cataract phacoemulsification.
- Trial name
- NCT01621789
- Testing
- dye of lutein, zeaxanthin, trypan blue
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of São Paulo
Bone Marrow Fibrosis
Special Stains in Assessment of Bone Marrow Fibrosis
This cross-sectional study aims to compare Picrosirius Red, Masson's Trichrome, and Reticulin stains for the detection and assessment of bone marrow fibrosis in trephine biopsy specimens.
- Trial name
- NCT07853417
- Volunteers
- 60 people
- Sponsor
- Assiut University
Port-Wine Stain
Combined Bipolar Radiofrequency&Pulsed Dye Laser Treatment
Port wine stain Birthmark is a congenital, progressive vascular malformation of human skin. However, even though the pulsed dye laser is considered as the treatment of choice for Port wine stain Birthmark the degree of fading can…
- Trial name
- NCT01775722
- Testing
- Pulsed Dye Laser, Combined Bipolar Radiofrequency&Pulsed Dye Laser
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, Irvine
Port Wine Stains
Lip Reduction Surgery for Port-wine Macrocheilia
Patients with port-wine stains often develop macrocheilia, however, there is currently no effective treatment to significantly reduce the three-dimensional volume increase of the lips.
- Trial name
- macrocheilia (NCT07128459)
- Testing
- The Five-Step lip reduction surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Tooth Discoloration
Etiology of Black Tooth Stain in Children
The aim of the present study was to investigate the relationship between the presence of black tooth stain (BS) and dental caries incidence, dental plaque scores and to examine the colonization of Streptococcus mutans…
- Trial name
- NCT05249491
- Testing
- Microbiological evaluation of dental plaques with children with or without black tooth stain
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Ege University
Primary Open-angle Glaucoma
Efficacy and Tolerability of an Innovative Formulation of BAK-free Latanoprost
This study evaluates the efficacy and tolerability of a new formulation of latanoprost without Benzalkonium Chloride (BAK-free).
- Trial name
- NCT03331770
- Testing
- Latanoprost Ophthalmic Product
- Where
- Argentina
- Volunteers
- 103 people
- Sponsor
- Laboratorios Poen
Corneal Staining
Assessment of Tear Film-Based Proteins Associated With Care Solution Induced Corneal Staining
The purpose of this study was to investigate the association of inflammatory mediators found in the tear film during the development and following the induction of contact lens solution-induced corneal staining.
- Trial name
- NCT01100424
- Testing
- Opti-Free RepleniSH, ReNu MultiPlus, Balafilcon A
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Port Wine Stain
Combined Alexandrite and Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks
Port wine stain is a congenital, progressive vascular malformation of skin involving post-capillary venules that occurs in an estimated 4 children per 1,000 live births.
- Trial name
- NCT00580944
- Testing
- laser treatment of port wine stain birthmarks
- Sponsor
- University of California, Irvine
Caries Class Ii
Effect of Nano Care Gold on Marginal Integrity of Resin Composite
The aim of this study to detect the effect of Nano Care Gold on marginal integrity of resin composite restoration
- Trial name
- NCT03669224
- Testing
- Nano Care Gold, No intervention, Chlorhexidine
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Black Stains
Effect of Herbal Toothpaste Versus Conventional One on Black Stains
Twenty eight children with black stains on their teeth were divided into 2 groups of toothpaste to assess their effect on parental satisfaction, recurrence rate of black stains and change in number of bacteria before and after…
- Trial name
- RCT (NCT06872827)
- Testing
- Herbal toothpaste
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Dental Caries in Children
Staining Potential and Caries Arresting Effect of Silver Diamine Fluoride⁄Potassium Iodide and Silver Diamine Fluoride
the main objective of this study is to evaluate staining potential and Caries Arresting Effect of silver diamine fluoride⁄potassium Iodide and silver diamine fluoride in carious anterior primary teeth
- Trial name
- NCT04196829
- Testing
- silver diamine fluoride ⁄ potassium Iodide, Silver Diamine Fluoride
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mature Cataracts
DY002: Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery
The primary objective of this study is to test the hypothesis that DYME is safe and effective as a drug to facilitate continuous curvilinear capsulorhexis (CCC) by selectively staining the anterior capsule.
- Trial name
- AQNA-DY002 (NCT00596492)
- Testing
- DYME
- Where
- 15 sites in United States, India
- Volunteers
- 200 people
- Sponsor
- Aqumen Biopharmaceuticals, N.A.
Capillary Malformations
Onreltea (Brimonidine) Gel In Pediatric Patients With Capillary Malformations
Capillary Malformations (CM) affect a significant proportion of otherwise healthy children and may lead to psychological discomfort if left untreated.
- Trial name
- NCT02764411
- Testing
- Brimonidine 0.33% gel
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- The Hospital for Sick Children
Oral Squamous Cell Carcinoma, Oral Epithelial Dysplasia
Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma
Oral cancer represents the sixth most common cancer worldwide whilst in Pakistan it ranks the second most common cancer in either gender.
- Trial name
- OSCC (NCT01987934)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Academy of Interdisciplinary Dental Education and Research
Mucosal Irritation, Image Quality
Lower Lugol's Solution Concentration on Reducing the Adverse Symptoms of Chromoendoscopy With Iodine Staining
This study was to test an optimal concentration of Lugol's solution which can reduce the mucosal irritation and provide high image quality to ensure endoscopy examination by a randomized blinded controlled trial.
- Trial name
- NCT03180944
- Testing
- 1.2% Lugol's solution, 1.0% Lugol's solution, 0.8% Lugol's solution
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Lynch Syndrome
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer
The purpose of this study is to determine the proportion of patients diagnosed with Lynch syndrome in colorectal cancer patients with the loss of staining by immunohistochemistry (IHC) of any of the mismatch repair (MMR)…
- Trial name
- NCT03047226
- Testing
- next-generation sequencing
- Where
- 7 sites in China
- Volunteers
- 311 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Contact Lens Complication, Contact Lens Acute Red Eye
Soft Contacts Observation of Risk and Education (SCORE)
Specific Aims 1. Develop risk assessment scores for SCL wearers 2. Test the scoring algorithm in SCL wearers who present with adverse events 3. Explore targeted patient education to reduce risk behaviors associated with SCL wear.
- Conditions
- Contact Lens Complication, Contact Lens Acute Red Eye, Contact Lens Related Corneal Infiltrate (Disorder), Contact Lens-Induced Corneal Fluorescein Staining
- Trial name
- SCORE (NCT03305484)
- Testing
- No intervention
- Where
- 5 sites in United States, Canada
- Volunteers
- 171 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Dry Eye
Comparison of Systane Free vs. Saline in the Treatment of Dry Eye
The purpose of this study is to compare the efficacy of Systane Free to Saline in decreasing the symptoms of dry eye after aggressive therapy.
- Trial name
- NCT00388791
- Testing
- Systane Free
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University