Clinical trials: Standard Care Control
Metastatic Cancer, Foregut Carcinoid Tumor
Study Comparing Standard of Care Chemotherapy With/ Without Sequential Cytoreductive Surgery for Patients With Metastatic Foregut Cancer and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid Levels
This study is designed for participants who have cancer of the upper gastrointestinal (GI) tract such as cancer of the esophagus, stomach, duodenum (the initial portion of your small intestine), pancreas, bile duct…
- Conditions
- Metastatic Cancer, Foregut Carcinoid Tumor, Gastric Adenocarcinoma, Gallbladder Adenocarcinoma
- Trial name
- NCT04931420
- Testing
- Standard of Care Chemotherapy, Video-Assisted Thoracic Surgery (VATS), Lobectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Iron-deficiency
Alternate Day vs. Daily Iron Supplementation in Iron Depleted Women in the Philippines
Iron is very important for our body and performs vital tasks. Iron deficiency is a worldwide health problem. The prevalence of anemia in women of reproductive age in Southeast Asia is estimated to be 46.6% in 2019, with iron…
- Trial name
- NCT05280821
- Testing
- daily ferrous sulfate, alternate day ferrous sulfate
- Where
- Philippines
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Total Knee Replacement Surgery, Total Hip Replacement Surgery
Xperience™ vs Normal Saline Irrigation Solution for Decreasing Bioburden After Primary Total Hip and Knee Arthroplasty
The purpose of this study is to evaluate the effectiveness of Xperience, a no rinse antimicrobial solution, on joint infection rates in patients undergoing total hip (THA) and total knee (TKA) arthoplasty surgery.
- Trial name
- NCT05577936
- Testing
- XPERIENCE Advanced Surgical Irrigation, Standard of Care Irrigation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Donor Sites, Wound Heal
A Trial Comparing a Cellulose Dressing to Two Standard of Care Dressings in Treating Split Thickness Donor Sites in Burn and Wound Patients.
This is a three arm study, comparing the Novadress, Mepilex Ag, and Xeroform Occlusive dressings for healing, drainage, and pain management. NovaDress is constructed of pure cellulose derived from tree pulp.
- Conditions
- Donor Sites, Wound Heal, Wound Drainage, Pain Management
- Trial name
- NCT05499104
- Testing
- NovaDress, Mepilex Ag, Xeroform
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Joseph M. Still Research Foundation, Inc.
Bariatric Surgery Candidate
Compliance With Standard Care vs Ready to Eat Meals Prior to Bariatric Surgery
Currently, a ketosis-inducing programme, usually a liquid meal replacement, is the standard of care for pre-operative dietary management.
- Trial name
- NCT06461247
- Testing
- Very Low Calorie Diet Ready-to-eat (VLCD RTE) meals, Standard Care Group
- Where
- 2 sites in Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
Episiotomy, Platelet Rich Plasma (PRP)
Platelet-Rich Plasma Versus Standard Care for Episiotomy Wound Healing in Postpartum Women
This study looks at whether a treatment made from a patient's own blood, called platelet-rich plasma (PRP), can help heal the cut made during childbirth (episiotomy) better than standard care alone.
- Conditions
- Episiotomy, Platelet Rich Plasma (PRP), Wound Healing, Obstetric
- Trial name
- PRP-EpiHeal (NCT07669285)
- Testing
- Autologous Platelet-Rich Plasma (PRP), Standard Wound Care
- Where
- Romania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Saint Andrew Hospital Constanta
Periodontitis
Effect of Novel Oral Hygiene Regimen on Non-surgical Treatment of Stage II and III Periodontitis
Achievement of adequate oral hygiene standards is critical to the successful treatment of gum disease. The improvement of the patient's adherence to good oral hygiene is of great importance to obtain the satisfactory treatment…
- Trial name
- NCT05137392
- Testing
- oral hygiene instruction
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Opioid-use Disorder, Pain, Acute
Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid Use
The aim of this study is to determine the effect of continuation of buprenorphine/naloxone in patients with history of Opioid Use Disorder (OUD) scheduled for surgery compared to reduced dose buprenorphine/naloxone prior to…
- Conditions
- Opioid-use Disorder, Pain, Acute, Surgery
- Trial name
- NCT03266445
- Testing
- buprenorphine/naloxone
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Knee Injuries, Shoulder Injuries
Internet Enhanced, Patient-Centered Orthopedic Care: A Prospective, Randomized, Controlled Pilot Trial
The investigators have previously reported on patient utilization of an eRehab patient education web portal that utilizes streaming, clinician prescribed video instruction to motivate and inform patients in self-care of their…
- Conditions
- Knee Injuries, Shoulder Injuries, Rotator Cuff Disease, Meniscus Tear
- Trial name
- NCT02025400
- Testing
- eRehab, Formal Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charlotte Sports Medicine Institute, PA
Post-operative Pain, Acute, Opioid Use, Unspecified
Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care
The goal of this clinical trial is to learn if the Pain Coach App will result in less opioids being prescribed to and used by patients undergoing Shoulder/Hip/Knee Arthroplasty surgery while maintaining the same or better pain…
- Conditions
- Post-operative Pain, Acute, Opioid Use, Unspecified, Arthroplasty Complications, Knee Osteoarthritis
- Trial name
- NCT06469177
- Testing
- Pain Coach App
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Hospitalized Patients 18 Years of Age or Older With Pain
Virtual Reality Pain Study
Investigating pain in hospitalized patients in two groups: virtual reality usage group vs standard of care
- Trial name
- VR Pain (NCT05293275)
- Testing
- EaseVRx Virtual Reality Headset
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Irritant Contact Dermatitis Due to Incontinence, Diaper Rash
Comparison of Wash Wipes and Standard Care in the Prevention of Incontinence-associated Dermatitis in Elderly
Incontinence is a widespread problem in all health care setting. One of the main complications of incontinence is inflammation of the skin in the genital and anal region, also known as incontinence-associated dermatitis (IAD).
- Conditions
- Irritant Contact Dermatitis Due to Incontinence, Diaper Rash, Pressure Ulcer, Incontinence-associated Dermatitis
- Trial name
- NCT02475512
- Testing
- Wash wipes (3M), water and pH neutral soap
- Where
- 11 sites in Belgium
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- University Ghent
Quality Health Care
Dural Puncture Epidural Vs Standard Epidural Technique in Parturient Receiving Continuous Labour Epidural Infusion
The goal of this study is to evaluate the quality and safety of labor analgesia by comparing the use of Dural puncture epidural technique to Standard epidural technique while maintaining labor analgesia by means of continuous…
- Trial name
- NCT06653036
- Testing
- Dural puncture epidural, Standard Epidural Technique
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Unintended Pregnancy
miPlan: A Trial of miPlan Intervention vs. Standard of Care
Using our experience in digital media, behavior theory, client-centered interventions, and family planning, we have prototyped a digital application ("app")-miPlan-to be used in the clinic waiting room prior to a contraceptive…
- Trial name
- NCT02396602
- Testing
- miPlan intervention
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Monotherapy, Dolutegravir
Early Simplified: A Trial to Compare the Efficacy of Standard of Care Combination Antiretroviral Therapy With a Simplified Dolutegravir Monotherapy in Patients With a Primary HIV-1 Infection
Long term toxicity of combination antiretroviral therapy (cART) is a substantial contributor to morbidity and mortality in chronically infected HIV positive individuals.
- Conditions
- Monotherapy, Dolutegravir, Primary HIV Infection, Treatment Efficacy
- Trial name
- NCT02551523
- Testing
- Dolutegravir, Standard of care combinational antiretroviral therapy
- Where
- Switzerland
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hiv
Healer-initiated HIV Counseling and Testing Versus Standard of Care in Rural South Africa
South Africa has made progress towards their 95-95-95 goals, yet a substantial proportion of the population do not test regularly.
- Trial name
- NCT06483854
- Testing
- HIV counseling and testing from a traditional health practitioner
- Where
- South Africa
- Volunteers
- 230,907 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Positive Mental Health
Family FINGER: Lifestyle Intervention Among Older Caregivers
The Family FINGER study enrolls caregivers aged 65 or older who live with and care for a spouse with cognitive impairment in North Savo, Finland (estimated n=100).
- Trial name
- NCT07627386
- Testing
- a multidomain lifestyle intervention
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tarja Välimäki
COVID-19
Shaping Care Home COVID-19 Testing Policy
The goal of this interventional study is to investigate whether continued use of regular asymptomatic testing in staff is a feasible, effective and cost-effective strategy to reduce the impact of COVID-19 in care homes.
- Trial name
- VIVALDI-CT (NCT05639205)
- Testing
- Lateral Flow Device
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University College, London
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University