Clinical trials: Staphylococcus Aureus Infections
Bacteremia
Virulence Determinants in S Aureus Bacteremia
The purpose of this study is to investigate why some people develop life-threatening infections caused by the bacteria Staphylococcus aureus, while other people do not.
- Trial name
- NCT00319826
- Testing
- No intervention
- Where
- United States
- Volunteers
- 1,354 people, healthy volunteers welcome
- Sponsor
- Duke University
Staphylococcus Aureus, Bacteremia
Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
Staphylococcus aureus, the most virulent of the many staphylococcal species, has been recognized as one of the most important and lethal human bacterial pathogens.
- Trial name
- NCT01352936
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Taipei Medical University WanFang Hospital
Infections, Nosocomial
Linezolid for the Treatment of Infections Caused by Methicillin Resistant Staphylococcus Aureus in Japan
Use of linezolid in patients with methicillin-resistant Staphylococcus aureus infections in Japan
- Trial name
- NCT00150332
- Testing
- linezolid
- Where
- 20 sites in Japan
- Volunteers
- 24 people
- Sponsor
- Pfizer
Bacteremia
Detecting Infections Rapidly and Easily for Bacteremia Trial (DIREBT)
To assure the uniform collection, handling, storage and transport of patient whole blood specimens and associated information to support validation of the T2 Bacteremia Assay.
- Trial name
- DIREBT (NCT01919762)
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- T2 Biosystems
MRSA Infection
Randomized Clinical Trial to Compare a Regimen of Trimethoprim-sulfamethoxazole Plus Rifampicin With a Regimen of Linezolid in the Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection
MRSA infections often require systemic antibiotic therapy and represent an important healthcare burden. Currently available treatment options are either only available in parenteral form (vancomycin) or expensive (linezolid).
- Trial name
- NCT00711854
- Testing
- trimethoprim-sulfamethoxazole (TMP-SMX), Linezolid, Rifampicin
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Geneva
Staphylococcus Aureus
Prospective Study of Staphylococcus Aureus Clinical Isolates Versus Colonization: RNAs as Potential Biomarkers for Bloodstream Infections
The primary objective is to demonstrate that the risk of S. aureus bacteremia (SAB) is correlated to the RNA III and SprD RNAs expression
- Trial name
- PROSAC (NCT03833102)
- Testing
- biological analysis
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Rennes University Hospital
Open Reduction and Internal Fixation of Extremity Fractures
MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants
A prospective trial conducted at Shock Trauma of patients between 18 years of age and older who have sustained a fracture with metal implanted.
- Trial name
- MICRO (NCT03132246)
- Testing
- Blood draws
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Maryland, Baltimore
Infections, Bacterial
Retapamulin Ointment in Healthy Adults Nasally Colonized With Staphylococcus Aureus
This is a Phase I/IIa randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and efficacy of Retapamulin ointment, 1% applied twice daily for 3 or 5 days to the anterior nares of healthy…
- Trial name
- NCT00539994
- Testing
- retapamulin
- Where
- 4 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Staphylococcus Aureus Bacteremia
Staphylococcus Aureus Bacteremia: Impact of an Intervention Program in Improving the Clinical Management and Review of the Clinical and Molecular Epidemiology
Staphylococcus aureus bacteremia: impact of an intervention program in improving the clinical management and review of the clinical and molecular epidemiology.
- Trial name
- NCT01971762
- Testing
- Follow recommendations based on scientific evidence to S. aureus bacteremia management, Not to follow recommendations based on scientific evidence to S. aureus bacteremia management
- Where
- 16 sites in Spain
- Volunteers
- 600 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Staphylococcus Aureus, Colonization, Asymptomatic
Decolonization Efficacy of Polyhexanide vs. Mupirocin
This pilot randomized controlled trial evaluates the feasibility, tolerability, and preliminary efficacy of a decolonization regimen using polyhexanide in reducing Staphylococcus aureus colonization in the preoperative phase of…
- Trial name
- SPADE (NCT06633588)
- Testing
- Polyhexanide, Mupirocin and Chlorhexidine
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Eluted Swab
Comparison of Elution Swab (ESwab) and Amies Transport Swabs for Screening Patients for Methicillin Resistant Staphylococcus Aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) Colonization
1.To assess whether the Elution swab (ESwab) is superior to Amies transport swabs for the detection of Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) in colonized patients and to…
- Trial name
- MRSA VRE (NCT00941122)
- Testing
- Eluted Swab
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation
Infection
Use of a Loading Dose of Vancomycin in Pediatric Dosing
Vancomycin is an antibiotic administered to children or adults for many types of infections. While it has been used to treat infections of children for more than 50 years we are still not completely certain about the best dose to…
- Trial name
- NCT01290237
- Testing
- vancomycin hydrocloride
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Boston Children's Hospital
Rheumatoid Arthritis, Staphylococcus Aureus Bacteremia
Bloodstream Infections in Patients With Rheumatoid Arthritis
Study of incidence and risk factors of staphylococcus aureus bacteremia in patients with rheumatoid arthritis compared with the general population in a nationwide cohort of all adult members of the population from 1996 until 2017…
- Trial name
- NCT03908086
- Testing
- Risk factors in RA cohort, Risk factors in general population
- Volunteers
- 6,000,000 people
- Sponsor
- Sabine Dieperink
Staphylococcal Infection
Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA"
The purpose of this study is to determine the optimal outpatient treatment strategy of uncomplicated skin and soft tissue infection (SSTI) in areas of the United States where the prevalence of Community-Acquired…
- Trial name
- NCT00729937
- Testing
- Cephalexin, Clindamycin, Trimethoprim-sulfamethoxazole
- Where
- 5 sites in United States
- Volunteers
- 2,265 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
MRSA Infection
Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients
The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level.
- Trial name
- MOSAR-04 (NCT00685867)
- Testing
- Rapid molecular MRSA test, Hand hygiene promotion
- Where
- Switzerland
- Volunteers
- 126,750 people
- Sponsor
- University Hospital, Geneva
Staphylococcus Aureus Infection
Staph Intervention for Effective Local Defense
Indigenous persons experience a high burden of Staphylococcus aureus (SA) invasive disease and skin and soft tissue infections. SA carriage on the skin is factor for development of SA infections.
- Trial name
- SHIELD (NCT06210594)
- Testing
- Mupirocin + Nozin + chlorhexidine gluconate, Education + Household supplies
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Staphylococcus Aureus, Wound Infection, Surgical
Staphylococcus Aureus Surgical Site Infection Multinational Epidemiology in Europe
This is a retrospective multinational, multicenter cohort study with a nested case-control. The study includes all surgical procedures performed at a participating site to prevent bias. Data will be assessed in two populations.
- Conditions
- Staphylococcus Aureus, Wound Infection, Surgical, Epidemiology
- Trial name
- SALT (NCT03353532)
- Where
- 14 sites in France, Germany and 3 more
- Volunteers
- 178,902 people
- Sponsor
- University of Cologne
Staphylococcal Infections
Safety, Tolerability, and Immunogenicity of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine With or Without Merck Aluminum Adjuvant (V710-002)
The purpose of this study was to evaluate the safety, tolerability, and immunogenicity of the Merck 0657nI S. aureus vaccine (V710) either with or without Merck Aluminum Adjuvant (MAA).
- Trial name
- NCT01324440
- Testing
- V710 (30 µg) with MAA, V710 (30 µg) without MAA
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Staphylococcus Aureus Infections
Impact of Rapid Detection of MRSA
The objective of this study is to evaluate the impact of the Alere\™ PBP2a test combined with pharmacist review of antimicrobial therapy, on clinical outcomes and cost in hospitalized patients with sterile site S.
- Trial name
- NCT02027389
- Where
- United States
- Sponsor
- Mayo Clinic
MRSA Colonization
A Novel Approach to Methicillin-resistant Staphylococcus Aureus (MRSA) Screening of Colonized Patients
Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in hospital settings. Colonization with MRSA puts patients at increased risk for invasive infections, and MRSA infections have been associated with high costs and…
- Trial name
- NCT01234831
- Testing
- nucleic acid amplification of nasal swab; nasal swab culture, Nasal swab culture
- Where
- United States
- Volunteers
- 463 people
- Sponsor
- Massachusetts General Hospital