Clinical trials: Staphylococcus Aureus Skin Infection
Cellulitis
Study of New Antibiotic Regimen for the Treatment of Uncomplicated Cellulitis in Emergency Department Patients
The primary aim of this study is to quantify the effectiveness of Bactrim as additional therapy for the treatment of uncomplicated cellulitis in adults, by comparing: standard therapy plus Bactrim, versus standard therapy plus…
- Trial name
- NCT00676130
- Testing
- trimethoprim-sulfamethoxazole, Cephalexin
- Where
- 3 sites in United States
- Volunteers
- 153 people
- Sponsor
- Brigham and Women's Hospital
MRSA
Community-Assoc. S. Aureus Colonization and Recurrent Infection in Pts With Uncomplicated S. Aureus Skin Abscesses
Infections due to S. aureus are a major healthcare burden. Currently there is not an effective way to prevent S. aureus infection.
- Trial name
- CIRCUS (NCT02690415)
- Testing
- Antibiotics Given, Antibiotics not given
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Southern Illinois University
Diabetic Foot, Staphylococcal Infections
Standard Treatment Associated With Phage Therapy Versus Placebo for Diabetic Foot Ulcers Infected by S. Aureus
The primary objective of this study is to compare the efficacy of standard treatment associated with a topical anti-staphylococcal bacteriophage cocktail versus standard treatment plus placebo for diabetic foot ulcers…
- Trial name
- PhagoPied (NCT02664740)
- Testing
- Topical anti-Staphylococcus bacteriophage therapy
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Skin Infection
A Phase Ⅱ Clinical Study of 9MW1411 Injection in Acute Bacterial Skin and Skin Structure Infections
In this study, a multicenter, randomized, double-blind, placebo-controlled trial design is used to evaluate the efficacy and safety of two doses of 9MW1411 injection in patients with ABSSSI caused by S. aureus.
- Trial name
- NCT05339802
- Testing
- 9MW1411 injection 1 combined with Linezolid, 9MW1411 injection 2 combined with Linezolid
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Abscess
Trial of Antibiotic Treatment for Skin Abscess in Patients at Risk for Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection
Patients will be enrolled in a multi-center study to prospectively evaluate outcome after treatment for an uncomplicated skin abscess. All patients will receive incision and drainage and wound cultures.
- Trial name
- NCT00829686
- Testing
- Septra
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Skin Diseases, Infectious, Skin Diseases, Bacterial
Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections
The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated skin and skin structure infections.
- Conditions
- Skin Diseases, Infectious, Skin Diseases, Bacterial, Staphylococcal Skin Infections
- Trial name
- NCT00210899
- Testing
- ceftobiprole medocaril, Vancomycin plus Ceftazidime
- Volunteers
- 828 people
- Sponsor
- Basilea Pharmaceutica
Methicillin-Resistant Staphylococcus Aureus, Atopic Dermatitis
The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA)
Staphylococcus aureus (S.aureus) is a bacterium that causes many painful skin and soft tissue conditions, such as scalded-skin syndrome, boils, or impetigo.
- Conditions
- Methicillin-Resistant Staphylococcus Aureus, Atopic Dermatitis, Eczema Herpeticum, MRSA
- Trial name
- MRSA (NCT00822276)
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis, Staphylococcus Aureus Bacteremia
Bloodstream Infections in Patients With Rheumatoid Arthritis
Study of incidence and risk factors of staphylococcus aureus bacteremia in patients with rheumatoid arthritis compared with the general population in a nationwide cohort of all adult members of the population from 1996 until 2017…
- Trial name
- NCT03908086
- Testing
- Risk factors in RA cohort, Risk factors in general population
- Volunteers
- 6,000,000 people
- Sponsor
- Sabine Dieperink
Staphylococcus Aureus Infection
Staph Intervention for Effective Local Defense
Indigenous persons experience a high burden of Staphylococcus aureus (SA) invasive disease and skin and soft tissue infections. SA carriage on the skin is factor for development of SA infections.
- Trial name
- SHIELD (NCT06210594)
- Testing
- Mupirocin + Nozin + chlorhexidine gluconate, Education + Household supplies
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Skin and Soft Tissue Infections (SSTIs)
S. Aureus, Skin and Soft Tissue Infections
Methicillin-resistant Staphylococcus aureus (MRSA) is reported as one of the main causative pathogen of community acquired SSTIs.
- Trial name
- SSTIs (NCT02796742)
- Testing
- Collecting samples from all patients presenting with SSTIs requiring drainage
- Where
- France
- Volunteers
- 249 people
- Sponsor
- Hospices Civils de Lyon
Atopic Dermatitis (AD), Scabies
Secondary Bacterial Infections and Nasal Colonization in Scabies and Atopic Dermatitis
This prospective observational study will evaluate the microbiological profile of secondary bacterial infection and nasal colonization in participants with scabies or atopic dermatitis.
- Conditions
- Atopic Dermatitis (AD), Scabies, Impetigo
- Trial name
- NCT07813611
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Cellulitis
Adjunctive Clindamycin for Cellulitis: C4C Trial.
The aim of this study is to see whether the addition of Clindamycin, a protein inhibiting antibiotic, to the standard antibiotic treatment of limb cellulitis, with Flucloxacillin, results in less tissue damage and a more rapid…
- Trial name
- C4C (NCT01876628)
- Testing
- Flucloxacillin, Clindamycin
- Where
- United Kingdom
- Volunteers
- 410 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Staphylococcus Aureus, Community-acquired Infections
Chlorhexidine Impregnated Cloths to Prevent Skin and Soft Tissue Infections in Marine Officer Candidates
Outbreaks of skin and soft tissue infections (SSTI) related to community associated Methicillin-resistant Staphylococcus aureus (MRSA) have become increasingly common in military training units.
- Conditions
- Staphylococcus Aureus, Community-acquired Infections, Staphylococcal Skin Infections
- Trial name
- NCT00475930
- Testing
- 2% chlorhexidine gluconate (CHG) impregnated cloths
- Where
- United States
- Volunteers
- 1,563 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Abscess, Methicillin-Resistant Staphylococcus Aureus Infection
Trial of Septra for Uncomplicated Skin Abscesses in Patients at Risk for Community Acquired Methicillin-Resistant Staphylococcus Aureus Infection
Patients will be enrolled in a multi-center study (Wilford Hall Medical Center and Brooke Army Medical Center) to prospectively evaluate outcome after treatment for an uncomplicated skin abscess.
- Trial name
- NCT00822692
- Testing
- Trim/ Sulfa DS
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Hyper-Immunoglobulin E. Syndrome (HEIS), Chronic Granulomatous Disease (CGD)
Skin Immunity Sample Collection Involving Blisters and Biopsies
Background: The way the body heals and protects itself from getting sick is called the immune response. Some people with weak immune systems get sick often or get rashes and skin infections.
- Trial name
- NCT03921515
- Testing
- Blister induction, Skin Biopsies
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Staphylococcal Infection
A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002)
The study investigates the efficacy and safety of MK-3009 in participants with skin infections, septicemia and right-sided infective endocarditis (RIE) caused by methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- NCT00770341
- Testing
- Daptomycin 4 mg/kg, Comparator: vancomycin, Daptomycin 6 mg/kg
- Volunteers
- 122 people
- Sponsor
- Merck Sharp & Dohme LLC
Atopic Dermatitis, Secondary Infection
Safety and Efficacy Study of Altabax Ointment in the Treatment of Secondarily Infected Atopic Dermatitis
Skin infections may complicate the treatment of atopic dermatitis.The use of topical ointments has become very important to avoid the use of oral antibiotics.
- Trial name
- NCT01064947
- Testing
- Retapamulin 1%
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Derm Research, PLLC
Atopic Dermatitis
Observer-Blinded Dose Escalating, Single Dose to Study Safety and Antimicrobial Efficacy of Gel vs. Placebo
A Randomized, Observer-Blinded, Vehicle Controlled, Single Dose, Dose Escalating, Single Application Within-patient Bilateral Comparison. The goal is to determine the safety and tolerability of DBI-001 Gel vs.
- Trial name
- NCT04192513
- Testing
- J. lividum
- Where
- Dominican Republic
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Skin Infection
Phase 2a Study of CG400549 for the Treatment of cABSSSI Caused by Methicillin-resistant Staphylococcus Aureus
Primary Objective: To make a preliminary assessment of the efficacy of CG400549 (960 mg daily) in subjects with cABSSSI (major cutaneous abscesses) due to MRSA.
- Trial name
- CG400549 (NCT01593761)
- Testing
- CG400549
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- CrystalGenomics, Inc.
Diabetic Foot, Staphylococcus Aureus
The Foot in Your Nose Study: Links Between Nasal Staphylococcus Aureus Colonies and Diabetic Foot Lesion Infections
The presence of S aureus in the nasal passages of diabetic patients may be a risk factor for diabetic foot lesion infections. Our aim is to compare the genetic profiles of S aureus strains found in the noses and on the foot…
- Trial name
- NCT01212120
- Testing
- Genetic profiling of bacterial cultures
- Where
- 4 sites in France
- Volunteers
- 278 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes