Clinical trials: Staphylococcus Infections
Methicillin Susceptible Staphylococcus Aureus (MSSA) Infection, Bone and Joint Infection
Pristinamycin in the Treatment of MSSA Bone and Joint Infection
Staphylococcus aureus represents the leading pathogen implicated in bone and joint infection (BJI), usually requiring prolonged combination antimicrobial therapy, which may be particularly challenging in the case of MDR bacteria…
- Trial name
- NCT03177343
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Hospices Civils de Lyon
Community-acquired Methicillin-resistant Staphylococcus Aureus Infection
New Mexico Honey Wound Treatment Research Study
In a time of emerging bacteria that are resistant to antibiotics, honey offers an alternative that has potential to reduce the heavy reliance on pharmaceutical antibiotics.
- Trial name
- NCT01748318
- Testing
- New Mexico Honey, Bactrim DS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- R. Stephen Rankin, M.D.
Staphylococcus Aureus Skin Infection
Human Immunity Against Staphylococcus Aureus Skin Infection
Background: Staphylococcus aureus, or staph, is commonly found on the skin and in the respiratory system. Sometimes people who get sick with staph infection do not get better with standard treatment.
- Trial name
- NCT02262819
- Testing
- S. aureus
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Staphylococcus Aureus Bloodstream Infection
A Phase I Study of XJ101 in Chinese Healthy Subjects
This is a randomized, double-blind, placebo-parallel intervention clinical study that will include approximately 38 healthy subjects based on inclusion and exclusion criteria.
- Trial name
- NCT06014736
- Testing
- XJ101 for Injection
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Starmab biologics（Shanghai）Co,.ltd
Staphylococcus Aureus
Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making
The study EPICS-6 consists of three study phases. Emergency Department patients are screened for nasal and pharyngeal colonisation with Methicillin sensitive and Methicillin resistant Staphylococcus aureus (MSSA/MRSA) using a…
- Trial name
- EPICS-6 (NCT03220386)
- Testing
- Decolonization by nasal Octinidin treatment and skin washings
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Toxic Shock Syndrome Staphylococcal
Prodromes of Menstrual Staphylococcal Toxic Shock
Menstrual staphylococcal toxic shock is a rare but severe disease, requiring intensive care in over 80% of cases. Menstrual staphylococcal toxic shock develops during the peri-menstrual period, in healthy young women colonized by…
- Trial name
- IPro-CTSm (NCT06124599)
- Testing
- Identification of symptoms of menstrual staphylococcal toxic shock in last three menstrual period, Identification of symptoms of menstrual in control patient in the last three menstrual period
- Where
- France
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Pneumonia, Pneumonia, Ventilator-Associated
Advanced Understanding of Staphylococcus Aureus and Pseudomonas Aeruginosa Infections in EuRopE - ICU
Intensive Care Unit (ICU) acquired pneumonia, including ventilator-associated pneumonia, is a frequently occurring health-care associated infection, which causes considerable morbidity, mortality and health care costs.
- Conditions
- Pneumonia, Pneumonia, Ventilator-Associated, Nosocomial Pneumonia
- Trial name
- ASPIRE-ICU (NCT02413242)
- Testing
- Various observed exposure(s) of interest
- Where
- Netherlands
- Volunteers
- 2,031 people
- Sponsor
- Jan Kluytmans
Multidrug Resistant Organisms, Healthcare Associated Infections
Effectiveness of Enhanced Terminal Room Disinfection to Prevent Healthcare-associated Infections (HAIs)
Enhanced terminal room disinfection is a novel, promising, but still unproven strategy for the prevention of healthcare-associated infections (HAIs) due to selected multidrug-resistant (MDR) bacterial pathogens.
- Trial name
- NCT01579370
- Testing
- Quaternary ammonium, Bleach, Quaternary ammonium and UV-C light
- Where
- 9 sites in United States
- Volunteers
- 21,395 people
- Sponsor
- Duke University
Staphylococcus Lugdunensis, Bacteremia
Virulence of Staphylococcus Lugdunensis in Severe Infections
The main objective is to identify new virulence factors produced by Staphylococcus lugdunensis that can be associated with clinical sign of severe infections and identified symptoms.
- Conditions
- Staphylococcus Lugdunensis, Bacteremia, Endocarditis, Virulence Factors
- Trial name
- VISLISI (NCT02026895)
- Testing
- Genetic blood sample
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Strasbourg, France
Staphylococcus Aureus Infection
A Study of a Recombinant Staphylococcus Aureus Vaccine (Escherichia Coli) in Healthy Adults
This is an open-label, dose-escalation pilot study with a total of 30 participants with 10 per dosage group. The aim of the pilot study is to explore the preliminary safety of an experimental recombinant staphylococcus aureus…
- Trial name
- NCT02820883
- Testing
- Staphylococcus aureus vaccine (60µg/per protein), Staphylococcus aureus vaccine (30µg/per protein), Staphylococcus aureus vaccine (15µg/per protein)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Staphylococcus Aureus, Motility Disorder
S. Aureus Decolonization in HPN Patients.
This trial focusses on identifying the most effective and safe long-term S. aureus carriage decolonization strategy in home parenteral nutrition patients.
- Trial name
- CARRIER (NCT03173053)
- Testing
- Doxycycline, Trimethoprim, Sulfamethoxazole/trimethoprim
- Where
- 4 sites in Denmark, Netherlands
- Volunteers
- 63 people
- Sponsor
- Radboud University Medical Center
Infection, Hemodialysis Patients
The Impact of Pharmaceutical Care on the Infection Control Measures Among Hemodialytic Patients
The study aims to assess the effectiveness of pharmaceutical care in reducing infection rates among hemodialysis patients with central venous (CV) lines.
- Trial name
- NCT06968754
- Testing
- Intervention Group
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- University of Sulaimani
Healthy, Staphylococcus Aureus Infection
Pharmacology of Mupirocin in Nasal Application in Healthy Volunteers: Monocentric Study
Mupirocin is an old antibiotic used topically since the 1970s. Initially used in the treatment of skin infections for its antistaphylococcal action, it is now part of the decolonization strategy for Staphylococcus aureus (SA)…
- Trial name
- MUPIPHARM (NCT06368856)
- Testing
- Mupirocin (50 mg), Mupirocin (500 mg), blood samples after Single dose part
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Staphylococcus Aureus, HIV Infections
Rifabutin Based Therapy for the Eradication of Staphylococcus Aureus Colonization in HIV Infected Adults
DESIGN: This single center, double-blinded, randomized phase II study is being conducted to assess the efficacy of a rifabutin based regimen to eliminate S. aureus colonization in HIV infected individuals.
- Trial name
- NCT00869518
- Testing
- rifabutin plus trimethoprim sulfamethoxazole
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia
18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia
Having bacteria in the blood can be very dangerous. This is called bacteraemia (or bacteremia) or bloodstream infection. It can lead to problems across the whole body, which is what happens in sepsis.
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia, Sepsis Bacterial, Bloodstream Infection
- Trial name
- PET-SAB (NCT05361135)
- Testing
- PET/CT
- Volunteers
- 820 people
- Sponsor
- University College, London
Diabetic Foot Ulcer, Pseudomonas Aeruginosa Infection
Bacteriophage Therapy TP-102 in Diabetic Foot Ulcers
This is a Phase I/IIa trial designed to evaluate topical bacteriophage therapy in patients with diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcer, Pseudomonas Aeruginosa Infection, Staphylococcus Aureus Infection, Acinetobacter Infection
- Trial name
- REVERSE (NCT04803708)
- Testing
- TP-102
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Technophage, SA
Staphylococcus Aureus, Health Care Associated Infection
Reducing Perioperative S. Aureus Transmission
The purpose of this study is to prevent the spread of S. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery.
- Conditions
- Staphylococcus Aureus, Health Care Associated Infection, Health Care Worker Patient Transmission
- Trial name
- NCT03638947
- Testing
- Swab and decolonization using povidone-iodine cleansing
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Randy Loftus
Prosthetic Joint Infection, Staphylococcus Aureus
Evaluation of the Antibiofilmogramme Test During Orthopaedic Device-Related Infection
This is an observational study that does not change routine care. The primary objective of this study is to investigate the correlation between the administration of an antibiotherapy able to prevent biofilm formation according…
- Conditions
- Prosthetic Joint Infection, Staphylococcus Aureus, Biofilm
- Trial name
- BJIBiofilm (NCT03263832)
- Testing
- Antibiofilmogramme
- Where
- France
- Volunteers
- 45 people
- Sponsor
- BioFilm Control
Staphylococcus Aureus Infection
A Clinical Trial to Evaluate a Recombinant Staphylococcus Aureus Vaccine (Escherichia Coli) in Healthy Adults
This is a single center, open-label phase1b clinical trial. The study will evaluate the safety and immunogenicity of an experimental recombinant staphylococcus aureus vaccine with different immunization schedules in healthy…
- Trial name
- NCT03966040
- Testing
- Inoculate Staphylococcus aureus vaccine(Escherichia Coli) at day 0-3-7, Inoculate Staphylococcus aureus vaccine(Escherichia Coli) at day 0/0-3-7, Inoculate Staphylococcus aureus vaccine(Escherichia Coli) at day 0/0-7
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Staphylococcus Aureus
Preventing the Spread of Infection in Nursing Homes
This study evaluates the feasibility of targeting more frequent gown and glove use for specific high risk moments of care in specific nursing home residents in order to prevent Staphylococcus aureus (SA) acquisition and infection.
- Trial name
- NCT03319368
- Testing
- Targeted gown and glove use
- Where
- 2 sites in United States
- Volunteers
- 367 people
- Sponsor
- University of Maryland, Baltimore