Clinical trials: Starvation
Obesity, Morbid, NASH
The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis
Background: Ketosis after bariatric surgery is a metabolic process that occurs when the body breaks down fat for energy because of not getting enough carbohydrates.
- Conditions
- Obesity, Morbid, NASH, Ketosis, Keto Acidosis
- Trial name
- NCT06338969
- Testing
- Carbohydrate Restriction after a Gastric Bypass
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Irritable Bowel Syndrome with Diarrhea, Purine Metabolism Disorder
B.Subtilis Attenuate Symptoms in Diarrhea-predominant Irritable Bowel Syndrome by Increasing Hypoxanthine Biosynthesis
This is a prospective, single-blind, randomized parallel study to investigate whether B. subtilis could improve clinical symptoms of IBS-D patients. Patients are randomly assigned by envelope method.
- Trial name
- NCT06612411
- Testing
- B. subtilis, Dead B. subtilis
- Where
- 2 sites in China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
PCOS Disease
Studying the Starvation Effect on Androgen Metabolism in 20 Healthy Young Women and Comparison to Women With PCOS.
In this study, the investigators wanted to investigate the energy homeostasis and the steroid metabolism of 20 healthy, young and normal weight women aged between 16-35 years before and after a 48 hours fasting period.
- Trial name
- SEA (NCT03573063)
- Testing
- Androgen metabolism after starvation
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anorexia Nervosa, Anorexia Nervosa, Atypical
Implementation of Evidence-Based Treatment of Restrictive Eating Disorder With Pronounced Starvation
In the Region Skåne in Sweden, the investigators have developed guidelines for providing intensive and evidence-based treatment during the first month in case of severe restrictive eating disorder with pronounced starvation.
- Conditions
- Anorexia Nervosa, Anorexia Nervosa, Atypical, Avoidant/Restrictive Food Intake Disorder, Starvation
- Trial name
- ROCKETLAUNCH (NCT04060433)
- Testing
- Family Therapy
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University Hospital
Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma
Short-term Starvation vs. Normal Diet Before Chemotherapy of Solid Tumors
Recent pre-clinical data provide strong evidence that short-term starvation before the administration of cytostatic drugs for the chemotherapy of solid tumors leads to significantly higher efficacy and lower toxicity levels.
- Conditions
- Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT02607826
- Testing
- Starvation
- Volunteers
- 298 people
- Sponsor
- University Hospital Tuebingen
Starvation, Caesarean Section
Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study
The primary aim of this randomised control trial is to assess the impact of pre-operative carbohydrate loading on the incidence of urinary ketone bodies when compared to standard care in elective caesarean section.
- Trial name
- NCT03220997
- Testing
- Vitaflow Preload
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Diabetes Mellitus, Diabetic Ketoacidosis
Starvation in the Treatment of Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are common, but serious metabolic disorders are often encountered in intensive care.
- Trial name
- NCT06186245
- Testing
- Early feeding with an oral diet
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Calorie Restriction, Aging
The Effect of Food Stimuli on the Calorie Restriction Response in Healthy Subjects
Calorie restriction extends life span and prevents aging-related diseases in several species. Odorants from live yeast restrain the beneficial effects of calorie restriction in Drosophila Melanogaster.
- Trial name
- NCT01243879
- Testing
- Stimuli of food smell and vision, No stimuli of food smell and vision
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Glucocorticoid Effect
The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- NCT05919992
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Starvation, Infection
The Influence of Short-term Starvation on Hepatitis B Virus Load
Hepatitis B virus is a small DNA virus that affects 400 million people worldwide. The virus infects the liver and previous studies, done in tissue culture and in animals, have shown that viral replication is affected by metabolic…
- Trial name
- NCT02364661
- Testing
- Over night starvation (fasting)
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Calorie Deficiency, Fasting
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
The goal of this clinical trial was to identify if duration of acute calorie restriction (CR)/fasting or combination CR with cold stimuli have any effects on mental and physical health-related markers, and to clarify if different…
- Conditions
- Calorie Deficiency, Fasting, Cold Exposure
- Trial name
- NCT05545943
- Testing
- 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Starvation
Effects of Glutamine on Gastric Emptying
Surgical patients are usually starved for 8 hours before operation in order to ensure the stomach is empty and thus reduce the chances of vomiting during the anaesthetic.
- Trial name
- NCT00943020
- Testing
- Nutricia PreOp nutritional supplement, Lipid, Glutamine
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Weight Loss, Starvation
Resistance Exercise and Protein During Weight Loss
The purpose of this study is to determine if post-exercise protein supplementation can rescue the anabolic response of muscle and bone to resistance exercise during caloric restriction.
- Trial name
- RIDE (NCT03600311)
- Testing
- Caloric Restriction, Post-Exercise Protein, Energy Balance
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Healthy, Obesity
Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes
In a previous study investigating the effects of intermittent fasting, our research group found evidence for higher glucose excursions and a reduced insulin response after a 36 hour fasting period as compared to an overnight…
- Conditions
- Healthy, Obesity, Type 2 Diabetes Mellitus, Type 1 Diabetes
- Trial name
- PROLOG (NCT04283318)
- Testing
- 12h fasting, 36h fasting
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Weight Loss, Starvation
Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
The purpose of this study is to determine if an increased protein intake can attenuate the suppression of metabolic and anabolic hormones during caloric restriction
- Trial name
- NCT02945410
- Testing
- Caloric Restriction, Protein, Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Critical Illness, Starvation
ICU Nutrition Study Bern
Nutritional treatment has become an essential component of the management of critically ill, due to better knowledge about positive impact of nutritional support.
- Conditions
- Critical Illness, Starvation, Enteral Nutrition
- Trial name
- NCT00574431
- Testing
- Data Collection, Nutritional management protocol
- Volunteers
- 200 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Non Small Cell Lung Cancer, Non-small Cell Lung Cancer
ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers
In this study, patients with small cell or non-small cell lung cancer will receive ADI-PEG 20, gemcitabine, and docetaxel after demonstrated progression on frontline therapy.
- Conditions
- Non Small Cell Lung Cancer, Non-small Cell Lung Cancer, Small-cell Lung Cancer, Small Cell Lung Carcinoma
- Trial name
- NCT05616624
- Testing
- ADI-PEG 20, Gemcitabine, Docetaxel
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Starvation
Metabolic Response Following Intake of 2 Metabolic Preconditioning Drinks
Surgical patients are usually starved for 8 to 12 hours before operation in order to reduce the chances of vomiting and other complications during the anaesthetic.
- Trial name
- NCT00909701
- Testing
- PreOP Booster, PreOP (Nutricia Clinical Care, Trowbridge, UK)
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Habile Adult Patients Referred to the Elective Gastroscopy
Reduction of Starvation Time Prior to Gastroscopy
The primary objective is to investigate whether intake of approximately 200 ml of sugary fluid 2 hours before the scheduled gastroscopy of the abdomen can reduce the discomfort of fasting period for patients without reducing the…
- Trial name
- RETIME (NCT01670253)
- Testing
- Group 1
- Volunteers
- 75 people
- Sponsor
- Odense University Hospital
Anovulation, Amenorrhea
Effects of Gynecological Age on LH Sensitivity to Energy Availability
The purpose of this experiment is to investigate whether the dependence of luteinizing hormone pulsatility on energy availability declines during adolescence.
- Conditions
- Anovulation, Amenorrhea, Infertility, Starvation
- Trial name
- NCT00260286
- Testing
- Energy availability
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ohio University