Clinical trials: Statin
Healthy Volunteers
Investigation of the Gut Microbiome and Statin Response
There is evidence that the bacteria that naturally reside in the gut can influence how well we respond to medications. Therefore this study will look at how rosuvastatin, a medication used to lower cholesterol levels, may change…
- Trial name
- INGEST (NCT04098003)
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sony Tuteja
Acute Metabolic Effects of Evolocumab and Atorvastatin
Studies to Gain Insight How the Drugs PCSK9-inhibitors and Statins Affect Cholesterol and Bile Acid Metabolism
Eight healthy male volunteers will be studied in consecutive sessions regarding the acute effect of evolocumab and atorvastatin on cholesterol and bile metabolism.
- Trial name
- NCT06140095
- Testing
- Evolocumab
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
CoQ10 Blood Levels, CoQ10 Blood Levels With Statin Use
An Open Label Study Evaluating the Effectiveness of Omega Q Plus® Resveratrol at Increasing Blood Levels of CoQ10
The primary objective of this study is to assess the blood levels of Coenzyme Q10 in healthy subjects when administered Omega Q Plus® Resveratrol for 28 days.The secondary objective of the study is to determine if statin use has…
- Trial name
- NCT02415114
- Testing
- Omega Q Plus Resveratrol (with 50mg CoQ10)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Primary Sclerosing Cholangitis, Inflammatory Bowel Diseases
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
PSC is a liver disease that has no medical cure. Patients with PSC are at a greatly increased risk of cancer and infection. Additionally, many patients require a liver transplant.
- Trial name
- NCT05912387
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obstructive Sleep Apnea of Adult
Impact of Intermittent Hypoxia on the Function of the Phagocytes
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA.
- Trial name
- NCT03618719
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Medication Adherence
A BCT Intervention for Medication Adherence Among Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among participants on primary prevention statin…
- Trial name
- NCT05273736
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwell Health
CMV
Effect of Atorvastatin on Subclinical Atherosclerosis
Statin administration is supposed to reduce subclinical atherosclerosis by decreasing LDL cholesterol levels, possibly via lipid-independent anti-inflammatory effect.
- Trial name
- NCT04101136
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Cognitive Impairment, Mild, Dementia
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo.
- Conditions
- Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
- Trial name
- PREVENTABLE (NCT04262206)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 106 sites in United States, Puerto Rico
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Hypercholesterolemia
Efficacy and Safety Study of Pitavastatin Versus Atorvastatin to Treat Hypercholesterolemia
Statin is an effective drug to treat hyperlipidemia (hypercholesterolemia), and it rarely leads to hepatic damage to the patients with hepatic disorder. For these patients, intensive monitoring is required.
- Trial name
- PITCH (NCT01166633)
- Testing
- pitavastatin, atorvastatin
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- JW Pharmaceutical
Healthy
Pharmacodynamic Drug Interaction Between Cilostazol and Statins
The purpose of this study is to evaluate pharmacodynamic drug interaction between cilostazol and statins (simvastatin as a CYP3A substrate and rosuvastatin as a non-CYP3A substrate) in healthy male subjects.
- Trial name
- SMCCPT-100 (NCT01870466)
- Testing
- Cilostazol, Simvastatin, Rosuvastatin
- Where
- South Korea
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Atherosclerotic Cardiovascular Disease
EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular Disease
The overall objective of this proposal is to develop and optimize a CDSS, including several nudges, to increase guideline-concordant statin prescribing for CVD risk (Nudge-CVD-CDSS).
- Trial name
- NCT07914777
- Testing
- EHR Nudge
- Where
- United States
- Volunteers
- 7,501 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hyperlipidemia, Insulin Resistance
Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling
Background: There is general agreement that statin-treatment of patients to lower plasma cholesterol levels can increase the incidence of type 2 diabetes mellitus (T2D) in some individuals1-5.
- Conditions
- Hyperlipidemia, Insulin Resistance, Type 2 Diabetes
- Trial name
- NCT02437084
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin
This is a Phase 1, Open-Label, 3-Period, Single-sequence, Drug-drug Interaction Study in Healthy Subjects to Assess the Effect of Cenicriviroc on the Pharmacokinetics (PK) of HMG-CoA Reductase Inhibitors [Rosuvastatin (ROS)…
- Trial name
- NCT02685462
- Testing
- Rosuvastatin, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Major Depressive Disorder, MDD
Efficacy of Statins Among Major Depressive Disorder
The goal of this clinical trial is to learn if drug Rosuvastatin 10 mg works to treat MDD in adults. It will also learn about the safety of Rosuvastatin 10 mg .The main questions it aims to answer are: Does Rusovastatin lower the…
- Trial name
- NCT06698666
- Testing
- Rosuvastatin 10 mg tablet., Sertraline Pill
- Where
- Egypt
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypercholesterolemia
Randomized Parallel Group Trial Of The Efficacy And Safety Of Ezetimibe With A Statin Versus Statin Dose Doubling In Patients With Persistent Primary Hypercholesterolemia (0653-152)(COMPLETED)
To compare the percent (%) change in plasma LDL-C concentration, after a six week course of treatment with ezetimibe 10 mg/day co-administered with an existing statin versus doubling of the existing statin dose
- Trial name
- NCT00652847
- Testing
- ezetimibe, statins
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Healthy Volunteers
A Study of Evacetrapib With Selected Statins in Healthy Chinese Participants
The main purpose of this study is to investigate how the body responds to evacetrapib and to evaluate the safety and the effect of evacetrapib, alone and in combination with selected statins, in healthy Chinese participants.
- Trial name
- NCT02156492
- Testing
- Evacetrapib, Simvastatin, Atorvastatin
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Socket Preservation
Socket Augmentation Using Atorvastatin With Or Without PRGF (Clinical and Histomorphometric Study)
Despite the numerous studies describing the benefits of PRGF (plasma rich in growth factors) and Statins separately , there has been a lack of clinical investigation into the simultaneous use of these agents in socket…
- Trial name
- NCT03228771
- Testing
- PRGF/ATV, ATV gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
HIV Infections
The Influence of Raltegravir on Pravastatin Pharmacokinetics(GRAPPA)
The purpose of this trial is to determine the effect of raltegravir on pravastatin pharmacokinetics and vice versa by intrasubject comparison.
- Trial name
- GRAPPA (NCT00665717)
- Testing
- Pravastatin, Raltegravir, Pravastatin and raltegravir
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Mitochondrial Diseases
Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity
The purpose of this study is to test how different doses of a statin, Lipitor, affect muscle health and function, and cardiovascular fitness.
- Trial name
- NCT03351998
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Atherosclerosis
Single Ascending Dose Safety Study of BMS-962476 in Healthy Subjects and Patients With Elevated Cholesterol on Statins
To obtain safety and tolerability information in healthy subjects is administered as a single dose
- Trial name
- NCT01587365
- Testing
- BMS-962476
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb